Incidental Mutation 'IGL02153:Mogat2'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mogat2
Ensembl Gene ENSMUSG00000052396
Gene Namemonoacylglycerol O-acyltransferase 2
SynonymsDGAT2L5, Mgat2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.142) question?
Stock #IGL02153
Quality Score
Chromosomal Location99219084-99238619 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 99223554 bp
Amino Acid Change Methionine to Lysine at position 141 (M141K)
Ref Sequence ENSEMBL: ENSMUSP00000064041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064231]
Predicted Effect possibly damaging
Transcript: ENSMUST00000064231
AA Change: M141K

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000064041
Gene: ENSMUSG00000052396
AA Change: M141K

Pfam:DAGAT 39 334 9.1e-120 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132343
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208323
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit resistance to diet induced obesity, hyperinsulinemia, hyperlipidemia, and steatosis with decreased lipid absorption and increased oxygen consumption when fed a high fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik T C 2: 152,441,241 I275T probably benign Het
BC005561 A G 5: 104,521,083 E1157G probably benign Het
Chd9 A T 8: 90,956,494 K521* probably null Het
Csn3 A T 5: 87,930,097 N154I possibly damaging Het
Dock2 A G 11: 34,230,670 S1716P probably benign Het
Dock7 A T 4: 98,958,067 S18T probably benign Het
Esrra G A 19: 6,913,822 T190I probably benign Het
F13b T C 1: 139,516,377 I483T probably damaging Het
Foxb1 T A 9: 69,759,703 M182L probably benign Het
Fsip2 T C 2: 82,978,721 F1795L probably benign Het
Gkn2 G A 6: 87,373,408 probably null Het
Gm8439 G A 4: 120,609,590 A93T unknown Het
Ift22 T C 5: 136,911,696 S72P probably benign Het
Kcnmb2 A G 3: 32,178,844 K24E probably damaging Het
Kcnq3 C A 15: 66,025,191 V287L probably damaging Het
Lrriq1 T A 10: 103,170,479 M1262L probably benign Het
Mb21d2 A G 16: 28,929,488 I59T probably benign Het
Mtdh C T 15: 34,131,250 L409F possibly damaging Het
Muc5ac C T 7: 141,818,800 Q2724* probably null Het
Myo15 T G 11: 60,498,397 L2040R probably damaging Het
Nodal C T 10: 61,424,545 T325I probably damaging Het
Pappa A T 4: 65,297,437 T1194S probably damaging Het
Pcdhb13 A C 18: 37,443,685 D372A probably damaging Het
Phf14 T A 6: 11,934,016 N292K probably damaging Het
Pigr T A 1: 130,849,056 probably null Het
Plcb1 T C 2: 135,387,853 I1131T probably benign Het
Plch1 T A 3: 63,781,351 D132V probably damaging Het
Plxnb2 C A 15: 89,165,813 E502* probably null Het
Prox2 T C 12: 85,087,929 N526S probably damaging Het
Rdm1 T A 11: 101,628,454 probably null Het
Rxfp1 C T 3: 79,660,120 E308K probably benign Het
Sgca T C 11: 94,963,284 T120A probably damaging Het
Sh3tc1 G A 5: 35,703,352 R1054W probably damaging Het
Smarcal1 C T 1: 72,633,055 probably benign Het
Spata45 T A 1: 191,039,761 M60K probably benign Het
St8sia6 T C 2: 13,656,905 M372V probably damaging Het
Tas2r126 T G 6: 42,434,664 S44A probably benign Het
Tcea3 T A 4: 136,273,634 probably benign Het
Tln1 T C 4: 43,546,857 I840V possibly damaging Het
Ttn T C 2: 76,898,341 probably benign Het
Ubr4 T A 4: 139,460,160 Y3846* probably null Het
Usp47 G A 7: 112,104,049 D1171N probably benign Het
Vmn2r114 G A 17: 23,291,808 T566I probably benign Het
Wdr35 G A 12: 9,008,535 R575Q probably null Het
Xkr5 A T 8: 18,933,667 C454S probably benign Het
Other mutations in Mogat2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01343:Mogat2 APN 7 99232568 missense possibly damaging 0.60
IGL02052:Mogat2 APN 7 99238564 start codon destroyed probably null 0.99
R0227:Mogat2 UTSW 7 99223132 missense probably benign 0.02
R0490:Mogat2 UTSW 7 99223144 missense probably benign 0.11
R1331:Mogat2 UTSW 7 99223515 missense possibly damaging 0.66
R1546:Mogat2 UTSW 7 99232559 missense probably damaging 1.00
R2879:Mogat2 UTSW 7 99222366 missense possibly damaging 0.46
R4954:Mogat2 UTSW 7 99238517 missense possibly damaging 0.95
R5040:Mogat2 UTSW 7 99238517 missense possibly damaging 0.95
R5184:Mogat2 UTSW 7 99223635 missense possibly damaging 0.90
R5822:Mogat2 UTSW 7 99219905 missense possibly damaging 0.82
R6056:Mogat2 UTSW 7 99223513 missense possibly damaging 0.95
R6256:Mogat2 UTSW 7 99219895 missense probably damaging 1.00
R6500:Mogat2 UTSW 7 99222346 missense probably benign 0.04
R7358:Mogat2 UTSW 7 99232466 missense possibly damaging 0.93
R7375:Mogat2 UTSW 7 99223698 missense probably damaging 1.00
Y5408:Mogat2 UTSW 7 99223630 missense probably damaging 1.00
Z1177:Mogat2 UTSW 7 99223629 missense probably damaging 1.00
Posted On2015-04-16