Incidental Mutation 'IGL02153:Mogat2'
ID 282125
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mogat2
Ensembl Gene ENSMUSG00000052396
Gene Name monoacylglycerol O-acyltransferase 2
Synonyms DGAT2L5, Mgat2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL02153
Quality Score
Status
Chromosome 7
Chromosomal Location 98868291-98887818 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 98872761 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 141 (M141K)
Ref Sequence ENSEMBL: ENSMUSP00000064041 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064231]
AlphaFold Q80W94
Predicted Effect possibly damaging
Transcript: ENSMUST00000064231
AA Change: M141K

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000064041
Gene: ENSMUSG00000052396
AA Change: M141K

DomainStartEndE-ValueType
Pfam:DAGAT 39 334 9.1e-120 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132343
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208323
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit resistance to diet induced obesity, hyperinsulinemia, hyperlipidemia, and steatosis with decreased lipid absorption and increased oxygen consumption when fed a high fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik T C 2: 152,283,161 (GRCm39) I275T probably benign Het
Chd9 A T 8: 91,683,122 (GRCm39) K521* probably null Het
Csn3 A T 5: 88,077,956 (GRCm39) N154I possibly damaging Het
Dock2 A G 11: 34,180,670 (GRCm39) S1716P probably benign Het
Dock7 A T 4: 98,846,304 (GRCm39) S18T probably benign Het
Esrra G A 19: 6,891,190 (GRCm39) T190I probably benign Het
F13b T C 1: 139,444,115 (GRCm39) I483T probably damaging Het
Foxb1 T A 9: 69,666,985 (GRCm39) M182L probably benign Het
Fsip2 T C 2: 82,809,065 (GRCm39) F1795L probably benign Het
Gkn2 G A 6: 87,350,390 (GRCm39) probably null Het
Gm8439 G A 4: 120,466,787 (GRCm39) A93T unknown Het
Ift22 T C 5: 136,940,550 (GRCm39) S72P probably benign Het
Kcnmb2 A G 3: 32,232,993 (GRCm39) K24E probably damaging Het
Kcnq3 C A 15: 65,897,040 (GRCm39) V287L probably damaging Het
Lrriq1 T A 10: 103,006,340 (GRCm39) M1262L probably benign Het
Mb21d2 A G 16: 28,748,240 (GRCm39) I59T probably benign Het
Mtdh C T 15: 34,131,396 (GRCm39) L409F possibly damaging Het
Muc5ac C T 7: 141,372,537 (GRCm39) Q2724* probably null Het
Myo15a T G 11: 60,389,223 (GRCm39) L2040R probably damaging Het
Nodal C T 10: 61,260,324 (GRCm39) T325I probably damaging Het
Pappa A T 4: 65,215,674 (GRCm39) T1194S probably damaging Het
Pcdhb13 A C 18: 37,576,738 (GRCm39) D372A probably damaging Het
Phf14 T A 6: 11,934,015 (GRCm39) N292K probably damaging Het
Pigr T A 1: 130,776,793 (GRCm39) probably null Het
Plcb1 T C 2: 135,229,773 (GRCm39) I1131T probably benign Het
Plch1 T A 3: 63,688,772 (GRCm39) D132V probably damaging Het
Plxnb2 C A 15: 89,050,016 (GRCm39) E502* probably null Het
Prox2 T C 12: 85,134,703 (GRCm39) N526S probably damaging Het
Rdm1 T A 11: 101,519,280 (GRCm39) probably null Het
Rxfp1 C T 3: 79,567,427 (GRCm39) E308K probably benign Het
Sgca T C 11: 94,854,110 (GRCm39) T120A probably damaging Het
Sh3tc1 G A 5: 35,860,696 (GRCm39) R1054W probably damaging Het
Smarcal1 C T 1: 72,672,214 (GRCm39) probably benign Het
Spata45 T A 1: 190,771,958 (GRCm39) M60K probably benign Het
St8sia6 T C 2: 13,661,716 (GRCm39) M372V probably damaging Het
Tas2r126 T G 6: 42,411,598 (GRCm39) S44A probably benign Het
Tcea3 T A 4: 136,000,945 (GRCm39) probably benign Het
Thoc2l A G 5: 104,668,949 (GRCm39) E1157G probably benign Het
Tln1 T C 4: 43,546,857 (GRCm39) I840V possibly damaging Het
Ttn T C 2: 76,728,685 (GRCm39) probably benign Het
Ubr4 T A 4: 139,187,471 (GRCm39) Y3846* probably null Het
Usp47 G A 7: 111,703,256 (GRCm39) D1171N probably benign Het
Vmn2r114 G A 17: 23,510,782 (GRCm39) T566I probably benign Het
Wdr35 G A 12: 9,058,535 (GRCm39) R575Q probably null Het
Xkr5 A T 8: 18,983,683 (GRCm39) C454S probably benign Het
Other mutations in Mogat2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01343:Mogat2 APN 7 98,881,775 (GRCm39) missense possibly damaging 0.60
IGL02052:Mogat2 APN 7 98,887,771 (GRCm39) start codon destroyed probably null 0.99
R0227:Mogat2 UTSW 7 98,872,339 (GRCm39) missense probably benign 0.02
R0490:Mogat2 UTSW 7 98,872,351 (GRCm39) missense probably benign 0.11
R1331:Mogat2 UTSW 7 98,872,722 (GRCm39) missense possibly damaging 0.66
R1546:Mogat2 UTSW 7 98,881,766 (GRCm39) missense probably damaging 1.00
R2879:Mogat2 UTSW 7 98,871,573 (GRCm39) missense possibly damaging 0.46
R4954:Mogat2 UTSW 7 98,887,724 (GRCm39) missense possibly damaging 0.95
R5040:Mogat2 UTSW 7 98,887,724 (GRCm39) missense possibly damaging 0.95
R5184:Mogat2 UTSW 7 98,872,842 (GRCm39) missense possibly damaging 0.90
R5822:Mogat2 UTSW 7 98,869,112 (GRCm39) missense possibly damaging 0.82
R6056:Mogat2 UTSW 7 98,872,720 (GRCm39) missense possibly damaging 0.95
R6256:Mogat2 UTSW 7 98,869,102 (GRCm39) missense probably damaging 1.00
R6500:Mogat2 UTSW 7 98,871,553 (GRCm39) missense probably benign 0.04
R7358:Mogat2 UTSW 7 98,881,673 (GRCm39) missense possibly damaging 0.93
R7375:Mogat2 UTSW 7 98,872,905 (GRCm39) missense probably damaging 1.00
Y5408:Mogat2 UTSW 7 98,872,837 (GRCm39) missense probably damaging 1.00
Z1177:Mogat2 UTSW 7 98,872,836 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16