Incidental Mutation 'IGL02154:Vmn1r78'
ID282162
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r78
Ensembl Gene ENSMUSG00000061602
Gene Namevomeronasal 1 receptor 78
SynonymsV1rg7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL02154
Quality Score
Status
Chromosome7
Chromosomal Location12150257-12159959 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 12152545 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 28 (I28V)
Ref Sequence ENSEMBL: ENSMUSP00000154797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]
Predicted Effect probably benign
Transcript: ENSMUST00000078039
AA Change: I28V

PolyPhen 2 Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: I28V

DomainStartEndE-ValueType
Pfam:TAS2R 3 304 5.7e-8 PFAM
Pfam:V1R 12 301 1.5e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209489
Predicted Effect probably benign
Transcript: ENSMUST00000228244
AA Change: I28V

PolyPhen 2 Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000228664
AA Change: I28V

PolyPhen 2 Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3632451O06Rik G A 14: 49,772,942 T436I possibly damaging Het
Armc3 G A 2: 19,286,137 probably null Het
AW551984 G A 9: 39,589,102 R787C possibly damaging Het
Cadm1 A T 9: 47,813,903 I321L probably benign Het
Cfap57 A G 4: 118,613,017 L222P probably damaging Het
Cox20 A G 1: 178,322,554 I98V probably benign Het
Dmrta1 A G 4: 89,691,913 N370S probably benign Het
Dnah17 A G 11: 118,124,261 F386L probably benign Het
Fam135b T C 15: 71,448,710 I1323V probably benign Het
Fndc3b A G 3: 27,538,117 S211P probably damaging Het
Galnt10 T G 11: 57,784,705 L597V probably damaging Het
Gtf2e2 T C 8: 33,755,961 probably null Het
Inpp4b T A 8: 81,969,501 probably benign Het
Lacc1 A G 14: 77,033,287 V269A probably benign Het
Lrmp T G 6: 145,138,241 M44R possibly damaging Het
Mdn1 A G 4: 32,740,395 D3750G probably benign Het
Mme A T 3: 63,343,555 Q339L probably benign Het
Mmp3 A T 9: 7,453,662 I428L probably benign Het
Myrf A T 19: 10,216,118 I558N probably damaging Het
Olfr671 C T 7: 104,975,981 M1I probably null Het
Phb A G 11: 95,675,171 I94V possibly damaging Het
Prg4 T A 1: 150,454,862 probably benign Het
Sirpb1a T C 3: 15,410,444 T344A probably damaging Het
Skap2 T C 6: 52,012,328 probably benign Het
Slc29a1 A G 17: 45,586,163 I399T probably damaging Het
Sorl1 C T 9: 42,004,034 V1300I probably benign Het
Tas2r117 T C 6: 132,803,715 V272A probably benign Het
Tctn2 C A 5: 124,608,561 noncoding transcript Het
Tmem51 T C 4: 142,031,778 N220D probably damaging Het
Trak2 T C 1: 58,908,729 D584G probably damaging Het
Vmn2r95 A C 17: 18,451,986 I662L probably benign Het
Vwa8 C A 14: 78,849,293 R4S possibly damaging Het
Other mutations in Vmn1r78
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Vmn1r78 APN 7 12153238 missense probably benign 0.10
IGL02019:Vmn1r78 APN 7 12152707 missense probably damaging 0.99
IGL02143:Vmn1r78 APN 7 12152480 missense probably benign
IGL02290:Vmn1r78 APN 7 12153155 missense probably damaging 1.00
IGL03012:Vmn1r78 APN 7 12153364 missense probably benign 0.32
IGL03256:Vmn1r78 APN 7 12152798 missense probably damaging 1.00
IGL03373:Vmn1r78 APN 7 12153343 missense possibly damaging 0.86
IGL03384:Vmn1r78 APN 7 12153209 missense possibly damaging 0.94
R0016:Vmn1r78 UTSW 7 12153352 missense probably benign 0.02
R1445:Vmn1r78 UTSW 7 12152581 missense possibly damaging 0.64
R1748:Vmn1r78 UTSW 7 12153323 missense probably damaging 1.00
R2017:Vmn1r78 UTSW 7 12153343 missense possibly damaging 0.86
R2032:Vmn1r78 UTSW 7 12153283 missense probably benign 0.00
R2198:Vmn1r78 UTSW 7 12152560 missense probably benign 0.06
R4330:Vmn1r78 UTSW 7 12152459 splice site probably null
R4564:Vmn1r78 UTSW 7 12152558 missense probably damaging 1.00
R4769:Vmn1r78 UTSW 7 12152798 missense probably damaging 1.00
R4801:Vmn1r78 UTSW 7 12152964 nonsense probably null
R4802:Vmn1r78 UTSW 7 12152964 nonsense probably null
R4860:Vmn1r78 UTSW 7 12152756 missense probably damaging 1.00
R4860:Vmn1r78 UTSW 7 12152756 missense probably damaging 1.00
R5648:Vmn1r78 UTSW 7 12152766 missense possibly damaging 0.92
R6561:Vmn1r78 UTSW 7 12152899 missense probably damaging 1.00
R6869:Vmn1r78 UTSW 7 12152749 missense probably benign 0.01
R6945:Vmn1r78 UTSW 7 12152905 missense probably benign 0.01
R7793:Vmn1r78 UTSW 7 12153314 missense probably benign 0.01
R7954:Vmn1r78 UTSW 7 12153300 nonsense probably null
Z1088:Vmn1r78 UTSW 7 12152714 missense probably damaging 1.00
Posted On2015-04-16