Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02154:Vmn1r78'

282162

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r78

Ensembl Gene

ENSMUSG00000061602

Gene Name

vomeronasal 1 receptor 78

Synonyms

V1rg7

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02154

Quality Score

Status

Chromosome

Chromosomal Location

12150257-12159959 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 12152545 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 28 (I28V)

Ref Sequence

ENSEMBL: ENSMUSP00000154797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]

Predicted Effect

probably benign
Transcript: ENSMUST00000078039
AA Change: I28V

PolyPhen 2 Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: I28V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	5.7e-8	PFAM
Pfam:V1R	12	301	1.5e-29	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209489

Predicted Effect

probably benign
Transcript: ENSMUST00000228244
AA Change: I28V

PolyPhen 2 Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000228664
AA Change: I28V

PolyPhen 2 Score 0.223 (Sensitivity: 0.91; Specificity: 0.88)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3632451O06Rik	G	A	14: 49,772,942	T436I	possibly damaging	Het
Armc3	G	A	2: 19,286,137		probably null	Het
AW551984	G	A	9: 39,589,102	R787C	possibly damaging	Het
Cadm1	A	T	9: 47,813,903	I321L	probably benign	Het
Cfap57	A	G	4: 118,613,017	L222P	probably damaging	Het
Cox20	A	G	1: 178,322,554	I98V	probably benign	Het
Dmrta1	A	G	4: 89,691,913	N370S	probably benign	Het
Dnah17	A	G	11: 118,124,261	F386L	probably benign	Het
Fam135b	T	C	15: 71,448,710	I1323V	probably benign	Het
Fndc3b	A	G	3: 27,538,117	S211P	probably damaging	Het
Galnt10	T	G	11: 57,784,705	L597V	probably damaging	Het
Gtf2e2	T	C	8: 33,755,961		probably null	Het
Inpp4b	T	A	8: 81,969,501		probably benign	Het
Lacc1	A	G	14: 77,033,287	V269A	probably benign	Het
Lrmp	T	G	6: 145,138,241	M44R	possibly damaging	Het
Mdn1	A	G	4: 32,740,395	D3750G	probably benign	Het
Mme	A	T	3: 63,343,555	Q339L	probably benign	Het
Mmp3	A	T	9: 7,453,662	I428L	probably benign	Het
Myrf	A	T	19: 10,216,118	I558N	probably damaging	Het
Olfr671	C	T	7: 104,975,981	M1I	probably null	Het
Phb	A	G	11: 95,675,171	I94V	possibly damaging	Het
Prg4	T	A	1: 150,454,862		probably benign	Het
Sirpb1a	T	C	3: 15,410,444	T344A	probably damaging	Het
Skap2	T	C	6: 52,012,328		probably benign	Het
Slc29a1	A	G	17: 45,586,163	I399T	probably damaging	Het
Sorl1	C	T	9: 42,004,034	V1300I	probably benign	Het
Tas2r117	T	C	6: 132,803,715	V272A	probably benign	Het
Tctn2	C	A	5: 124,608,561		noncoding transcript	Het
Tmem51	T	C	4: 142,031,778	N220D	probably damaging	Het
Trak2	T	C	1: 58,908,729	D584G	probably damaging	Het
Vmn2r95	A	C	17: 18,451,986	I662L	probably benign	Het
Vwa8	C	A	14: 78,849,293	R4S	possibly damaging	Het

Other mutations in Vmn1r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01129:Vmn1r78	APN	7	12153238	missense	probably benign	0.10
IGL02019:Vmn1r78	APN	7	12152707	missense	probably damaging	0.99
IGL02143:Vmn1r78	APN	7	12152480	missense	probably benign
IGL02290:Vmn1r78	APN	7	12153155	missense	probably damaging	1.00
IGL03012:Vmn1r78	APN	7	12153364	missense	probably benign	0.32
IGL03256:Vmn1r78	APN	7	12152798	missense	probably damaging	1.00
IGL03373:Vmn1r78	APN	7	12153343	missense	possibly damaging	0.86
IGL03384:Vmn1r78	APN	7	12153209	missense	possibly damaging	0.94
R0016:Vmn1r78	UTSW	7	12153352	missense	probably benign	0.02
R1445:Vmn1r78	UTSW	7	12152581	missense	possibly damaging	0.64
R1748:Vmn1r78	UTSW	7	12153323	missense	probably damaging	1.00
R2017:Vmn1r78	UTSW	7	12153343	missense	possibly damaging	0.86
R2032:Vmn1r78	UTSW	7	12153283	missense	probably benign	0.00
R2198:Vmn1r78	UTSW	7	12152560	missense	probably benign	0.06
R4330:Vmn1r78	UTSW	7	12152459	splice site	probably null
R4564:Vmn1r78	UTSW	7	12152558	missense	probably damaging	1.00
R4769:Vmn1r78	UTSW	7	12152798	missense	probably damaging	1.00
R4801:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4802:Vmn1r78	UTSW	7	12152964	nonsense	probably null
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R4860:Vmn1r78	UTSW	7	12152756	missense	probably damaging	1.00
R5648:Vmn1r78	UTSW	7	12152766	missense	possibly damaging	0.92
R6561:Vmn1r78	UTSW	7	12152899	missense	probably damaging	1.00
R6869:Vmn1r78	UTSW	7	12152749	missense	probably benign	0.01
R6945:Vmn1r78	UTSW	7	12152905	missense	probably benign	0.01
R7793:Vmn1r78	UTSW	7	12153314	missense	probably benign	0.01
R7954:Vmn1r78	UTSW	7	12153300	nonsense	probably null
Z1088:Vmn1r78	UTSW	7	12152714	missense	probably damaging	1.00

Posted On

2015-04-16