Incidental Mutation 'IGL02154:Tas2r117'
| ID |
282166 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r117
|
| Ensembl Gene |
ENSMUSG00000058349 |
| Gene Name |
taste receptor, type 2, member 117 |
| Synonyms |
T2R17, mGR17, Tas2r17, mt2r54 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.048)
|
| Stock # |
IGL02154
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
132779864-132780856 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 132780678 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 272
(V272A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000069768
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068302]
|
| AlphaFold |
Q7M715 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000068302
AA Change: V272A
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000069768
Gene: ENSMUSG00000058349
AA Change: V272A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
307 |
1.2e-85 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Armc3 |
G |
A |
2: 19,290,948 (GRCm39) |
|
probably null |
Het |
| Armh4 |
G |
A |
14: 50,010,399 (GRCm39) |
T436I |
possibly damaging |
Het |
| AW551984 |
G |
A |
9: 39,500,398 (GRCm39) |
R787C |
possibly damaging |
Het |
| Cadm1 |
A |
T |
9: 47,725,201 (GRCm39) |
I321L |
probably benign |
Het |
| Cfap57 |
A |
G |
4: 118,470,214 (GRCm39) |
L222P |
probably damaging |
Het |
| Cox20 |
A |
G |
1: 178,150,119 (GRCm39) |
I98V |
probably benign |
Het |
| Dmrta1 |
A |
G |
4: 89,580,150 (GRCm39) |
N370S |
probably benign |
Het |
| Dnah17 |
A |
G |
11: 118,015,087 (GRCm39) |
F386L |
probably benign |
Het |
| Fam135b |
T |
C |
15: 71,320,559 (GRCm39) |
I1323V |
probably benign |
Het |
| Fndc3b |
A |
G |
3: 27,592,266 (GRCm39) |
S211P |
probably damaging |
Het |
| Galnt10 |
T |
G |
11: 57,675,531 (GRCm39) |
L597V |
probably damaging |
Het |
| Gtf2e2 |
T |
C |
8: 34,245,989 (GRCm39) |
|
probably null |
Het |
| Inpp4b |
T |
A |
8: 82,696,130 (GRCm39) |
|
probably benign |
Het |
| Irag2 |
T |
G |
6: 145,083,967 (GRCm39) |
M44R |
possibly damaging |
Het |
| Lacc1 |
A |
G |
14: 77,270,727 (GRCm39) |
V269A |
probably benign |
Het |
| Mdn1 |
A |
G |
4: 32,740,395 (GRCm39) |
D3750G |
probably benign |
Het |
| Mme |
A |
T |
3: 63,250,976 (GRCm39) |
Q339L |
probably benign |
Het |
| Mmp3 |
A |
T |
9: 7,453,662 (GRCm39) |
I428L |
probably benign |
Het |
| Myrf |
A |
T |
19: 10,193,482 (GRCm39) |
I558N |
probably damaging |
Het |
| Or52e8 |
C |
T |
7: 104,625,188 (GRCm39) |
M1I |
probably null |
Het |
| Phb1 |
A |
G |
11: 95,565,997 (GRCm39) |
I94V |
possibly damaging |
Het |
| Prg4 |
T |
A |
1: 150,330,613 (GRCm39) |
|
probably benign |
Het |
| Sirpb1a |
T |
C |
3: 15,475,504 (GRCm39) |
T344A |
probably damaging |
Het |
| Skap2 |
T |
C |
6: 51,989,308 (GRCm39) |
|
probably benign |
Het |
| Slc29a1 |
A |
G |
17: 45,897,089 (GRCm39) |
I399T |
probably damaging |
Het |
| Sorl1 |
C |
T |
9: 41,915,330 (GRCm39) |
V1300I |
probably benign |
Het |
| Tctn2 |
C |
A |
5: 124,746,624 (GRCm39) |
|
noncoding transcript |
Het |
| Tmem51 |
T |
C |
4: 141,759,089 (GRCm39) |
N220D |
probably damaging |
Het |
| Trak2 |
T |
C |
1: 58,947,888 (GRCm39) |
D584G |
probably damaging |
Het |
| Vmn1r78 |
A |
G |
7: 11,886,472 (GRCm39) |
I28V |
probably benign |
Het |
| Vmn2r95 |
A |
C |
17: 18,672,248 (GRCm39) |
I662L |
probably benign |
Het |
| Vwa8 |
C |
A |
14: 79,086,733 (GRCm39) |
R4S |
possibly damaging |
Het |
|
| Other mutations in Tas2r117 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01611:Tas2r117
|
APN |
6 |
132,780,450 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01611:Tas2r117
|
APN |
6 |
132,780,447 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02140:Tas2r117
|
APN |
6 |
132,780,558 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02466:Tas2r117
|
APN |
6 |
132,779,963 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02942:Tas2r117
|
APN |
6 |
132,780,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03328:Tas2r117
|
APN |
6 |
132,780,041 (GRCm39) |
missense |
probably benign |
0.40 |
|
PIT4480001:Tas2r117
|
UTSW |
6 |
132,780,014 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0380:Tas2r117
|
UTSW |
6 |
132,780,551 (GRCm39) |
nonsense |
probably null |
|
|
R0456:Tas2r117
|
UTSW |
6 |
132,780,354 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0699:Tas2r117
|
UTSW |
6 |
132,780,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2118:Tas2r117
|
UTSW |
6 |
132,780,129 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2265:Tas2r117
|
UTSW |
6 |
132,780,188 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4420:Tas2r117
|
UTSW |
6 |
132,780,312 (GRCm39) |
nonsense |
probably null |
|
|
R4861:Tas2r117
|
UTSW |
6 |
132,780,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4861:Tas2r117
|
UTSW |
6 |
132,780,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5233:Tas2r117
|
UTSW |
6 |
132,780,585 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5384:Tas2r117
|
UTSW |
6 |
132,780,117 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6750:Tas2r117
|
UTSW |
6 |
132,779,817 (GRCm39) |
start gained |
probably benign |
|
|
R6852:Tas2r117
|
UTSW |
6 |
132,779,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6902:Tas2r117
|
UTSW |
6 |
132,780,288 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6946:Tas2r117
|
UTSW |
6 |
132,780,288 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7129:Tas2r117
|
UTSW |
6 |
132,780,350 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7412:Tas2r117
|
UTSW |
6 |
132,780,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Tas2r117
|
UTSW |
6 |
132,780,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7768:Tas2r117
|
UTSW |
6 |
132,780,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7953:Tas2r117
|
UTSW |
6 |
132,780,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9629:Tas2r117
|
UTSW |
6 |
132,780,374 (GRCm39) |
missense |
probably benign |
0.41 |
|
| Posted On |
2015-04-16 |
Incidental Mutation