Incidental Mutation 'IGL02155:Cyp2a5'
ID282191
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2a5
Ensembl Gene ENSMUSG00000005547
Gene Namecytochrome P450, family 2, subfamily a, polypeptide 5
SynonymsCoh
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL02155
Quality Score
Status
Chromosome7
Chromosomal Location26835305-26843548 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 26843046 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 491 (F491Y)
Ref Sequence ENSEMBL: ENSMUSP00000005685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005685] [ENSMUST00000168869] [ENSMUST00000169007]
Predicted Effect probably benign
Transcript: ENSMUST00000005685
AA Change: F491Y

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000005685
Gene: ENSMUSG00000005547
AA Change: F491Y

DomainStartEndE-ValueType
transmembrane domain 5 24 N/A INTRINSIC
Pfam:p450 34 491 4e-151 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165641
Predicted Effect probably benign
Transcript: ENSMUST00000168869
SMART Domains Protein: ENSMUSP00000130640
Gene: ENSMUSG00000005547

DomainStartEndE-ValueType
transmembrane domain 5 24 N/A INTRINSIC
PDB:2PG7|D 25 60 9e-14 PDB
SCOP:d1jpza_ 30 60 6e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169007
SMART Domains Protein: ENSMUSP00000128865
Gene: ENSMUSG00000005547

DomainStartEndE-ValueType
Pfam:p450 1 116 1.1e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170631
SMART Domains Protein: ENSMUSP00000127829
Gene: ENSMUSG00000005547

DomainStartEndE-ValueType
Pfam:p450 1 59 2.9e-20 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice exhibit strain-specific cytochrome activity levels. Mice homozygous for a knock-out allele exhibit slower clearance of nicotine and cotinine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs A G 5: 125,506,286 H302R probably null Het
Abi3bp A T 16: 56,587,964 H254L probably damaging Het
Adcy3 G A 12: 4,212,142 W1064* probably null Het
Arvcf C T 16: 18,403,900 P70S probably damaging Het
Ceacam3 A G 7: 17,162,981 D624G possibly damaging Het
Cntrl T A 2: 35,160,238 probably benign Het
Disp2 C T 2: 118,791,804 R1006C probably damaging Het
Dnajc22 T C 15: 99,101,005 Y24H probably damaging Het
Fat2 A G 11: 55,262,419 F3656L probably benign Het
Fbxo31 A G 8: 121,559,075 F212S probably damaging Het
Fsip2 T C 2: 82,998,352 M6831T probably benign Het
Gpi1 G T 7: 34,230,189 Q9K possibly damaging Het
Hmcn1 T A 1: 150,563,598 S5495C probably damaging Het
Ift74 A G 4: 94,679,251 I394V probably benign Het
Kcnh5 G A 12: 75,176,538 probably benign Het
Lars2 A G 9: 123,454,982 D745G probably damaging Het
Mitd1 T A 1: 37,885,275 I65F probably benign Het
Mlxip T C 5: 123,453,392 M878T probably benign Het
Mrgpra4 T C 7: 47,981,544 Y103C probably damaging Het
Notch2 T C 3: 98,138,490 I1657T probably damaging Het
Olfr1028 T A 2: 85,952,008 M315K probably benign Het
Orc1 T A 4: 108,590,677 D40E probably benign Het
Rnf40 T C 7: 127,590,716 probably benign Het
Sema4d A G 13: 51,703,267 V643A probably benign Het
Taf7 A T 18: 37,643,511 M1K probably null Het
Tnfsf10 A T 3: 27,335,231 D147V possibly damaging Het
Trove2 C T 1: 143,761,269 probably null Het
Usp45 T A 4: 21,798,743 probably null Het
Wdr62 T C 7: 30,262,643 D2G probably damaging Het
Zp2 T A 7: 120,144,117 I50F probably benign Het
Other mutations in Cyp2a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01354:Cyp2a5 APN 7 26837103 missense possibly damaging 0.82
IGL01744:Cyp2a5 APN 7 26841009 missense probably damaging 1.00
IGL03076:Cyp2a5 APN 7 26835874 missense probably damaging 0.99
PIT4696001:Cyp2a5 UTSW 7 26840979 missense probably benign 0.18
R0762:Cyp2a5 UTSW 7 26838873 nonsense probably null
R0980:Cyp2a5 UTSW 7 26839006 splice site probably null
R1078:Cyp2a5 UTSW 7 26835541 missense probably benign 0.33
R1511:Cyp2a5 UTSW 7 26835936 missense probably damaging 1.00
R1780:Cyp2a5 UTSW 7 26841876 intron probably benign
R1803:Cyp2a5 UTSW 7 26835546 splice site probably null
R1899:Cyp2a5 UTSW 7 26839033 nonsense probably null
R1977:Cyp2a5 UTSW 7 26835922 missense probably benign 0.15
R2215:Cyp2a5 UTSW 7 26840475 missense probably damaging 1.00
R2258:Cyp2a5 UTSW 7 26837103 missense possibly damaging 0.82
R3051:Cyp2a5 UTSW 7 26842985 missense possibly damaging 0.77
R3052:Cyp2a5 UTSW 7 26842985 missense possibly damaging 0.77
R3053:Cyp2a5 UTSW 7 26842985 missense possibly damaging 0.77
R4387:Cyp2a5 UTSW 7 26841054 missense probably damaging 0.97
R4832:Cyp2a5 UTSW 7 26835545 critical splice donor site probably null
R5054:Cyp2a5 UTSW 7 26841104 missense probably damaging 1.00
R5622:Cyp2a5 UTSW 7 26835874 missense probably damaging 1.00
R5867:Cyp2a5 UTSW 7 26842958 missense probably benign 0.09
R5998:Cyp2a5 UTSW 7 26837153 missense probably benign 0.00
R6186:Cyp2a5 UTSW 7 26843388 unclassified probably benign
R7338:Cyp2a5 UTSW 7 26842947 missense probably damaging 1.00
R7350:Cyp2a5 UTSW 7 26836783 missense probably benign 0.37
R7536:Cyp2a5 UTSW 7 26840478 missense probably damaging 1.00
R7722:Cyp2a5 UTSW 7 26837118 missense probably benign 0.31
R7831:Cyp2a5 UTSW 7 26835515 missense possibly damaging 0.71
R7983:Cyp2a5 UTSW 7 26840441 missense probably benign 0.40
R8805:Cyp2a5 UTSW 7 26841105 missense probably damaging 0.99
Z1088:Cyp2a5 UTSW 7 26841107 missense probably damaging 1.00
Z1176:Cyp2a5 UTSW 7 26835497 missense probably damaging 1.00
Z1176:Cyp2a5 UTSW 7 26836774 missense probably damaging 1.00
Posted On2015-04-16