Incidental Mutation 'IGL02155:Mrgpra4'
| ID |
282192 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Mrgpra4
|
| Ensembl Gene |
ENSMUSG00000067173 |
| Gene Name |
MAS-related GPR, member A4 |
| Synonyms |
MrgA4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL02155
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
47630585-47631843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 47631292 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 103
(Y103C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000084327
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087092]
|
| AlphaFold |
Q91WW2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087092
AA Change: Y103C
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000084327
Gene: ENSMUSG00000067173
AA Change: Y103C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
38 |
270 |
1.3e-10 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aacs |
A |
G |
5: 125,583,350 (GRCm39) |
H302R |
probably null |
Het |
| Abi3bp |
A |
T |
16: 56,408,327 (GRCm39) |
H254L |
probably damaging |
Het |
| Adcy3 |
G |
A |
12: 4,262,142 (GRCm39) |
W1064* |
probably null |
Het |
| Arvcf |
C |
T |
16: 18,222,650 (GRCm39) |
P70S |
probably damaging |
Het |
| Ceacam3 |
A |
G |
7: 16,896,906 (GRCm39) |
D624G |
possibly damaging |
Het |
| Cntrl |
T |
A |
2: 35,050,250 (GRCm39) |
|
probably benign |
Het |
| Cyp2a5 |
T |
A |
7: 26,542,471 (GRCm39) |
F491Y |
probably benign |
Het |
| Disp2 |
C |
T |
2: 118,622,285 (GRCm39) |
R1006C |
probably damaging |
Het |
| Dnajc22 |
T |
C |
15: 98,998,886 (GRCm39) |
Y24H |
probably damaging |
Het |
| Fat2 |
A |
G |
11: 55,153,245 (GRCm39) |
F3656L |
probably benign |
Het |
| Fbxo31 |
A |
G |
8: 122,285,814 (GRCm39) |
F212S |
probably damaging |
Het |
| Fsip2 |
T |
C |
2: 82,828,696 (GRCm39) |
M6831T |
probably benign |
Het |
| Gpi1 |
G |
T |
7: 33,929,614 (GRCm39) |
Q9K |
possibly damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,439,349 (GRCm39) |
S5495C |
probably damaging |
Het |
| Ift74 |
A |
G |
4: 94,567,488 (GRCm39) |
I394V |
probably benign |
Het |
| Kcnh5 |
G |
A |
12: 75,223,312 (GRCm39) |
|
probably benign |
Het |
| Lars2 |
A |
G |
9: 123,284,047 (GRCm39) |
D745G |
probably damaging |
Het |
| Mitd1 |
T |
A |
1: 37,924,356 (GRCm39) |
I65F |
probably benign |
Het |
| Mlxip |
T |
C |
5: 123,591,455 (GRCm39) |
M878T |
probably benign |
Het |
| Notch2 |
T |
C |
3: 98,045,806 (GRCm39) |
I1657T |
probably damaging |
Het |
| Or5m11 |
T |
A |
2: 85,782,352 (GRCm39) |
M315K |
probably benign |
Het |
| Orc1 |
T |
A |
4: 108,447,874 (GRCm39) |
D40E |
probably benign |
Het |
| Rnf40 |
T |
C |
7: 127,189,888 (GRCm39) |
|
probably benign |
Het |
| Ro60 |
C |
T |
1: 143,637,007 (GRCm39) |
|
probably null |
Het |
| Sema4d |
A |
G |
13: 51,857,303 (GRCm39) |
V643A |
probably benign |
Het |
| Taf7 |
A |
T |
18: 37,776,564 (GRCm39) |
M1K |
probably null |
Het |
| Tnfsf10 |
A |
T |
3: 27,389,380 (GRCm39) |
D147V |
possibly damaging |
Het |
| Usp45 |
T |
A |
4: 21,798,743 (GRCm39) |
|
probably null |
Het |
| Wdr62 |
T |
C |
7: 29,962,068 (GRCm39) |
D2G |
probably damaging |
Het |
| Zp2 |
T |
A |
7: 119,743,340 (GRCm39) |
I50F |
probably benign |
Het |
|
| Other mutations in Mrgpra4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00790:Mrgpra4
|
APN |
7 |
47,631,052 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02083:Mrgpra4
|
APN |
7 |
47,630,808 (GRCm39) |
nonsense |
probably null |
|
|
IGL02577:Mrgpra4
|
APN |
7 |
47,630,981 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02674:Mrgpra4
|
APN |
7 |
47,630,690 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02696:Mrgpra4
|
APN |
7 |
47,631,251 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0357:Mrgpra4
|
UTSW |
7 |
47,631,574 (GRCm39) |
missense |
probably benign |
|
|
R0543:Mrgpra4
|
UTSW |
7 |
47,631,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0677:Mrgpra4
|
UTSW |
7 |
47,630,728 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1163:Mrgpra4
|
UTSW |
7 |
47,631,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1217:Mrgpra4
|
UTSW |
7 |
47,631,085 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2255:Mrgpra4
|
UTSW |
7 |
47,631,523 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R4191:Mrgpra4
|
UTSW |
7 |
47,630,867 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4303:Mrgpra4
|
UTSW |
7 |
47,630,684 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4472:Mrgpra4
|
UTSW |
7 |
47,631,539 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4757:Mrgpra4
|
UTSW |
7 |
47,630,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4976:Mrgpra4
|
UTSW |
7 |
47,631,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Mrgpra4
|
UTSW |
7 |
47,631,535 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5034:Mrgpra4
|
UTSW |
7 |
47,631,317 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5119:Mrgpra4
|
UTSW |
7 |
47,631,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Mrgpra4
|
UTSW |
7 |
47,630,755 (GRCm39) |
missense |
probably benign |
|
|
R6800:Mrgpra4
|
UTSW |
7 |
47,631,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7163:Mrgpra4
|
UTSW |
7 |
47,631,238 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7585:Mrgpra4
|
UTSW |
7 |
47,631,377 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7636:Mrgpra4
|
UTSW |
7 |
47,630,721 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8162:Mrgpra4
|
UTSW |
7 |
47,631,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8352:Mrgpra4
|
UTSW |
7 |
47,631,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8452:Mrgpra4
|
UTSW |
7 |
47,631,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8812:Mrgpra4
|
UTSW |
7 |
47,631,481 (GRCm39) |
missense |
probably benign |
|
|
R8996:Mrgpra4
|
UTSW |
7 |
47,630,945 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9026:Mrgpra4
|
UTSW |
7 |
47,631,208 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
X0028:Mrgpra4
|
UTSW |
7 |
47,631,168 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation