Incidental Mutation 'IGL02156:Olfr934'
ID282228
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr934
Ensembl Gene ENSMUSG00000057424
Gene Nameolfactory receptor 934
SynonymsMOR224-6, GA_x6K02T2PVTD-32678895-32677963
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL02156
Quality Score
Status
Chromosome9
Chromosomal Location38981026-38988315 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 38982546 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 166 (Y166F)
Ref Sequence ENSEMBL: ENSMUSP00000150864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074211] [ENSMUST00000214324] [ENSMUST00000216238] [ENSMUST00000216823]
Predicted Effect possibly damaging
Transcript: ENSMUST00000074211
AA Change: Y166F

PolyPhen 2 Score 0.715 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000073835
Gene: ENSMUSG00000057424
AA Change: Y166F

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.7e-48 PFAM
Pfam:7TM_GPCR_Srsx 33 222 7.2e-9 PFAM
Pfam:7tm_1 39 286 5.4e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214324
AA Change: Y166F

PolyPhen 2 Score 0.715 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect probably benign
Transcript: ENSMUST00000216238
Predicted Effect possibly damaging
Transcript: ENSMUST00000216823
AA Change: Y166F

PolyPhen 2 Score 0.715 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930408O17Rik G A 12: 104,871,307 noncoding transcript Het
Adam33 G A 2: 131,053,158 probably benign Het
Akr7a5 C A 4: 139,314,269 A163D probably damaging Het
Arap1 T C 7: 101,388,730 probably benign Het
Arhgap8 A G 15: 84,770,035 I306V possibly damaging Het
Asf1a C T 10: 53,606,143 A17V probably benign Het
Atp1a4 A T 1: 172,257,962 S25T probably benign Het
BC030867 C T 11: 102,255,039 S47F probably damaging Het
Cbln4 T C 2: 172,042,208 I31V probably benign Het
Ccdc93 T G 1: 121,448,276 L172R possibly damaging Het
Ceacam9 T C 7: 16,723,619 probably benign Het
Crhr1 C A 11: 104,163,883 N107K probably benign Het
Cyp11b1 T A 15: 74,835,797 M488L probably benign Het
Dnah7a A G 1: 53,419,723 V3752A probably benign Het
Dnhd1 G A 7: 105,721,744 V4744M probably damaging Het
Dstyk C A 1: 132,449,926 N423K probably benign Het
Exph5 T C 9: 53,375,641 S1341P probably damaging Het
Fam161b T C 12: 84,354,753 H409R probably benign Het
Fbxo21 A G 5: 117,994,668 probably benign Het
Flt1 A G 5: 147,681,741 I230T probably damaging Het
Gm9931 T C 1: 147,281,628 noncoding transcript Het
Grk6 T C 13: 55,449,361 F36L possibly damaging Het
Grm1 G T 10: 10,719,976 A636D probably damaging Het
Hectd1 A T 12: 51,754,133 probably benign Het
Hltf G A 3: 20,092,807 V577I possibly damaging Het
Lrrc8c A G 5: 105,607,493 D378G probably damaging Het
Mcoln1 C A 8: 3,512,657 S6* probably null Het
Meis1 A T 11: 19,011,292 S194T probably benign Het
Myo1h A C 5: 114,353,911 probably benign Het
Nop9 T A 14: 55,753,283 C557* probably null Het
Nrap T C 19: 56,321,000 D1619G probably damaging Het
Olfr1314 A T 2: 112,092,016 H228Q probably benign Het
Olfr854 A G 9: 19,567,198 M59T probably damaging Het
Pard3b T A 1: 61,767,950 D41E possibly damaging Het
Parp14 G T 16: 35,858,597 Q334K probably benign Het
Phf3 A T 1: 30,808,778 I1228K probably damaging Het
Polr1b T A 2: 129,123,879 F814I probably benign Het
Rsph1 T G 17: 31,258,116 S282R probably benign Het
Son T C 16: 91,656,104 S580P possibly damaging Het
Sptbn5 G T 2: 120,047,617 probably benign Het
Ssr2 T A 3: 88,583,788 probably null Het
Tfpt A G 7: 3,629,040 S24P probably damaging Het
Tg A G 15: 66,705,348 T1507A probably benign Het
Trpm7 A G 2: 126,799,243 probably benign Het
Wwox G A 8: 114,448,159 probably null Het
Ythdf2 C T 4: 132,204,508 R447H possibly damaging Het
Zfp385c A G 11: 100,629,019 F368S probably damaging Het
Zfp488 A G 14: 33,970,400 S269P possibly damaging Het
Zhx1 A C 15: 58,054,049 V267G possibly damaging Het
Other mutations in Olfr934
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1061:Olfr934 UTSW 9 38982483 missense probably damaging 1.00
R1604:Olfr934 UTSW 9 38982618 missense probably benign 0.01
R1776:Olfr934 UTSW 9 38982894 missense probably damaging 1.00
R3499:Olfr934 UTSW 9 38982465 missense probably damaging 1.00
R3761:Olfr934 UTSW 9 38982366 missense possibly damaging 0.94
R3876:Olfr934 UTSW 9 38982870 missense probably damaging 1.00
R4191:Olfr934 UTSW 9 38983017 missense probably benign 0.01
R4192:Olfr934 UTSW 9 38983017 missense probably benign 0.01
R4333:Olfr934 UTSW 9 38982588 missense possibly damaging 0.85
R4876:Olfr934 UTSW 9 38982626 nonsense probably null
R5539:Olfr934 UTSW 9 38982277 missense possibly damaging 0.85
R6916:Olfr934 UTSW 9 38982904 missense probably benign 0.14
R7097:Olfr934 UTSW 9 38982618 missense probably benign 0.01
R7338:Olfr934 UTSW 9 38982520 missense probably damaging 0.99
R8116:Olfr934 UTSW 9 38982873 missense probably damaging 1.00
Posted On2015-04-16