Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02156:Zfp488'

282241

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp488

Ensembl Gene

ENSMUSG00000044519

Gene Name

zinc finger protein 488

Synonyms

LOC382867

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02156

Quality Score

Status

Chromosome

Chromosomal Location

33689027-33700721 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 33692357 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 269 (S269P)

Ref Sequence

ENSEMBL: ENSMUSP00000132436 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166737]

AlphaFold

Q5HZG9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000166737
AA Change: S269P

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000132436
Gene: ENSMUSG00000044519
AA Change: S269P

Domain	Start	End	E-Value	Type
low complexity region	161	175	N/A	INTRINSIC
low complexity region	244	270	N/A	INTRINSIC
ZnF_C2H2	272	294	2.89e1	SMART
ZnF_C2H2	314	336	5.06e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930408O17Rik	G	A	12: 104,837,566 (GRCm39)		noncoding transcript	Het
Adam33	G	A	2: 130,895,078 (GRCm39)		probably benign	Het
Akr7a5	C	A	4: 139,041,580 (GRCm39)	A163D	probably damaging	Het
Arap1	T	C	7: 101,037,937 (GRCm39)		probably benign	Het
Asf1a	C	T	10: 53,482,239 (GRCm39)	A17V	probably benign	Het
Atp1a4	A	T	1: 172,085,529 (GRCm39)	S25T	probably benign	Het
Cbln4	T	C	2: 171,884,128 (GRCm39)	I31V	probably benign	Het
Ccdc93	T	G	1: 121,376,005 (GRCm39)	L172R	possibly damaging	Het
Ceacam9	T	C	7: 16,457,544 (GRCm39)		probably benign	Het
Crhr1	C	A	11: 104,054,709 (GRCm39)	N107K	probably benign	Het
Cyp11b1	T	A	15: 74,707,646 (GRCm39)	M488L	probably benign	Het
Dnah7a	A	G	1: 53,458,882 (GRCm39)	V3752A	probably benign	Het
Dnhd1	G	A	7: 105,370,951 (GRCm39)	V4744M	probably damaging	Het
Dstyk	C	A	1: 132,377,664 (GRCm39)	N423K	probably benign	Het
Exph5	T	C	9: 53,286,941 (GRCm39)	S1341P	probably damaging	Het
Fam161b	T	C	12: 84,401,527 (GRCm39)	H409R	probably benign	Het
Fbxo21	A	G	5: 118,132,733 (GRCm39)		probably benign	Het
Flt1	A	G	5: 147,618,551 (GRCm39)	I230T	probably damaging	Het
Gm9931	T	C	1: 147,157,366 (GRCm39)		noncoding transcript	Het
Grk6	T	C	13: 55,597,174 (GRCm39)	F36L	possibly damaging	Het
Grm1	G	T	10: 10,595,720 (GRCm39)	A636D	probably damaging	Het
Hectd1	A	T	12: 51,800,916 (GRCm39)		probably benign	Het
Hltf	G	A	3: 20,146,971 (GRCm39)	V577I	possibly damaging	Het
Hrob	C	T	11: 102,145,865 (GRCm39)	S47F	probably damaging	Het
Lrrc8c	A	G	5: 105,755,359 (GRCm39)	D378G	probably damaging	Het
Mcoln1	C	A	8: 3,562,657 (GRCm39)	S6*	probably null	Het
Meis1	A	T	11: 18,961,292 (GRCm39)	S194T	probably benign	Het
Myo1h	A	C	5: 114,491,972 (GRCm39)		probably benign	Het
Nop9	T	A	14: 55,990,740 (GRCm39)	C557*	probably null	Het
Nrap	T	C	19: 56,309,432 (GRCm39)	D1619G	probably damaging	Het
Or10d1c	T	A	9: 38,893,842 (GRCm39)	Y166F	possibly damaging	Het
Or4f61	A	T	2: 111,922,361 (GRCm39)	H228Q	probably benign	Het
Or7g34	A	G	9: 19,478,494 (GRCm39)	M59T	probably damaging	Het
Pard3b	T	A	1: 61,807,109 (GRCm39)	D41E	possibly damaging	Het
Parp14	G	T	16: 35,678,967 (GRCm39)	Q334K	probably benign	Het
Phf3	A	T	1: 30,847,859 (GRCm39)	I1228K	probably damaging	Het
Polr1b	T	A	2: 128,965,799 (GRCm39)	F814I	probably benign	Het
Prr5	A	G	15: 84,654,236 (GRCm39)	I306V	possibly damaging	Het
Rsph1	T	G	17: 31,477,090 (GRCm39)	S282R	probably benign	Het
Son	T	C	16: 91,452,992 (GRCm39)	S580P	possibly damaging	Het
Sptbn5	G	T	2: 119,878,098 (GRCm39)		probably benign	Het
Ssr2	T	A	3: 88,491,095 (GRCm39)		probably null	Het
Tfpt	A	G	7: 3,632,039 (GRCm39)	S24P	probably damaging	Het
Tg	A	G	15: 66,577,197 (GRCm39)	T1507A	probably benign	Het
Trpm7	A	G	2: 126,641,163 (GRCm39)		probably benign	Het
Wwox	G	A	8: 115,174,899 (GRCm39)		probably null	Het
Ythdf2	C	T	4: 131,931,819 (GRCm39)	R447H	possibly damaging	Het
Zfp385c	A	G	11: 100,519,845 (GRCm39)	F368S	probably damaging	Het
Zhx1	A	C	15: 57,917,445 (GRCm39)	V267G	possibly damaging	Het

Other mutations in Zfp488

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00160:Zfp488	APN	14	33,693,026 (GRCm39)	missense	probably benign	0.00
IGL02668:Zfp488	APN	14	33,692,777 (GRCm39)	missense	probably benign	0.01
R0504:Zfp488	UTSW	14	33,692,497 (GRCm39)	missense	probably damaging	0.97
R4021:Zfp488	UTSW	14	33,693,110 (GRCm39)	missense	probably benign	0.01
R4022:Zfp488	UTSW	14	33,693,110 (GRCm39)	missense	probably benign	0.01
R4291:Zfp488	UTSW	14	33,692,851 (GRCm39)	missense	possibly damaging	0.83
R6180:Zfp488	UTSW	14	33,692,751 (GRCm39)	missense	possibly damaging	0.66
R6927:Zfp488	UTSW	14	33,692,755 (GRCm39)	missense	probably benign
R7687:Zfp488	UTSW	14	33,692,357 (GRCm39)	missense	possibly damaging	0.83
R8416:Zfp488	UTSW	14	33,693,052 (GRCm39)	missense	probably benign	0.04
R8857:Zfp488	UTSW	14	33,692,760 (GRCm39)	missense	probably benign	0.38
R9151:Zfp488	UTSW	14	33,692,695 (GRCm39)	missense	possibly damaging	0.66

Posted On

2015-04-16