Incidental Mutation 'IGL02157:Gbp11'
ID 282269
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gbp11
Ensembl Gene ENSMUSG00000092021
Gene Name guanylate binding protein 11
Synonyms Gm7141
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # IGL02157
Quality Score
Status
Chromosome 5
Chromosomal Location 105470908-105494338 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 105475374 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 325 (V325M)
Ref Sequence ENSEMBL: ENSMUSP00000132552 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100960] [ENSMUST00000171587]
AlphaFold A9YVJ5
Predicted Effect possibly damaging
Transcript: ENSMUST00000100960
AA Change: V325M

PolyPhen 2 Score 0.877 (Sensitivity: 0.83; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000098520
Gene: ENSMUSG00000092021
AA Change: V325M

DomainStartEndE-ValueType
Pfam:GBP 16 279 1.5e-122 PFAM
Pfam:GBP_C 281 574 3.4e-114 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000171587
AA Change: V325M

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000132552
Gene: ENSMUSG00000092021
AA Change: V325M

DomainStartEndE-ValueType
Pfam:GBP 16 279 4.9e-117 PFAM
Pfam:GBP_C 281 442 2.7e-75 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b T C 5: 8,855,487 (GRCm39) probably benign Het
Amotl1 A T 9: 14,483,011 (GRCm39) probably benign Het
Amph A T 13: 19,288,401 (GRCm39) T297S possibly damaging Het
Arhgap31 A G 16: 38,444,263 (GRCm39) V198A probably damaging Het
Bop1 T C 15: 76,339,772 (GRCm39) D216G possibly damaging Het
Cdh13 T C 8: 119,232,410 (GRCm39) I38T possibly damaging Het
Clmn T C 12: 104,748,177 (GRCm39) T457A probably benign Het
Clstn2 A C 9: 97,423,928 (GRCm39) M279R probably benign Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Fam83h A T 15: 75,876,904 (GRCm39) V208E probably damaging Het
Fer A G 17: 64,445,894 (GRCm39) N785S probably benign Het
Fnip1 T C 11: 54,378,589 (GRCm39) L225P probably damaging Het
Glis1 A G 4: 107,484,758 (GRCm39) T418A probably benign Het
Hook2 C T 8: 85,727,779 (GRCm39) probably benign Het
Hoxa6 C A 6: 52,185,171 (GRCm39) C145F possibly damaging Het
Lyst G A 13: 13,835,541 (GRCm39) C1741Y probably benign Het
Mbd5 T C 2: 49,168,987 (GRCm39) V1156A probably benign Het
Mon2 G A 10: 122,849,377 (GRCm39) P1308S probably damaging Het
Mta2 T A 19: 8,924,613 (GRCm39) probably benign Het
Nup188 T A 2: 30,219,385 (GRCm39) L867* probably null Het
Oca2 G A 7: 55,974,545 (GRCm39) probably null Het
Or13a22 T A 7: 140,072,847 (GRCm39) C99S probably damaging Het
Or6c88 A G 10: 129,407,019 (GRCm39) E165G probably damaging Het
Or7e166 T A 9: 19,624,585 (GRCm39) V154E probably benign Het
Plekhh2 A G 17: 84,874,370 (GRCm39) probably benign Het
Pramel22 A T 4: 143,380,947 (GRCm39) C359S probably damaging Het
Rhbdd3 T C 11: 5,055,424 (GRCm39) probably benign Het
Timeless T A 10: 128,078,255 (GRCm39) V255E probably benign Het
Tmt1b T G 10: 128,796,486 (GRCm39) T108P possibly damaging Het
Trh A T 6: 92,219,948 (GRCm39) S123T probably benign Het
Ugdh C T 5: 65,580,035 (GRCm39) A252T probably damaging Het
Zfp619 A G 7: 39,184,288 (GRCm39) Y106C probably damaging Het
Zic5 G A 14: 122,696,924 (GRCm39) P564S unknown Het
Other mutations in Gbp11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01329:Gbp11 APN 5 105,475,482 (GRCm39) critical splice acceptor site probably null
IGL01347:Gbp11 APN 5 105,479,194 (GRCm39) splice site probably benign
IGL01762:Gbp11 APN 5 105,475,473 (GRCm39) missense probably benign
Quilt UTSW 5 105,473,374 (GRCm39) missense probably damaging 1.00
Tilted UTSW 5 105,478,919 (GRCm39) missense probably damaging 1.00
R0550:Gbp11 UTSW 5 105,491,616 (GRCm39) missense probably benign 0.28
R0647:Gbp11 UTSW 5 105,478,830 (GRCm39) missense possibly damaging 0.93
R1530:Gbp11 UTSW 5 105,475,355 (GRCm39) missense probably damaging 0.99
R1612:Gbp11 UTSW 5 105,474,462 (GRCm39) missense possibly damaging 0.72
R1677:Gbp11 UTSW 5 105,475,277 (GRCm39) missense probably damaging 1.00
R1738:Gbp11 UTSW 5 105,474,510 (GRCm39) missense probably benign 0.02
R2063:Gbp11 UTSW 5 105,476,450 (GRCm39) nonsense probably null
R2869:Gbp11 UTSW 5 105,478,866 (GRCm39) missense probably benign 0.00
R2869:Gbp11 UTSW 5 105,478,866 (GRCm39) missense probably benign 0.00
R2870:Gbp11 UTSW 5 105,478,866 (GRCm39) missense probably benign 0.00
R2870:Gbp11 UTSW 5 105,478,866 (GRCm39) missense probably benign 0.00
R2873:Gbp11 UTSW 5 105,478,866 (GRCm39) missense probably benign 0.00
R3915:Gbp11 UTSW 5 105,478,978 (GRCm39) missense probably damaging 1.00
R4854:Gbp11 UTSW 5 105,473,374 (GRCm39) missense probably damaging 1.00
R5140:Gbp11 UTSW 5 105,478,919 (GRCm39) missense probably damaging 1.00
R5534:Gbp11 UTSW 5 105,478,904 (GRCm39) missense probably damaging 1.00
R6091:Gbp11 UTSW 5 105,479,254 (GRCm39) missense possibly damaging 0.95
R6336:Gbp11 UTSW 5 105,473,355 (GRCm39)
R6351:Gbp11 UTSW 5 105,475,464 (GRCm39) missense probably benign 0.07
R6956:Gbp11 UTSW 5 105,476,241 (GRCm39) critical splice donor site probably null
R7371:Gbp11 UTSW 5 105,489,971 (GRCm39) missense probably benign 0.06
R7393:Gbp11 UTSW 5 105,475,443 (GRCm39) missense possibly damaging 0.60
R7410:Gbp11 UTSW 5 105,491,774 (GRCm39) missense probably damaging 1.00
R7443:Gbp11 UTSW 5 105,478,816 (GRCm39) critical splice donor site probably null
R7898:Gbp11 UTSW 5 105,472,798 (GRCm39) missense probably benign 0.00
R8465:Gbp11 UTSW 5 105,472,928 (GRCm39) missense probably benign 0.00
R8467:Gbp11 UTSW 5 105,475,457 (GRCm39) missense probably damaging 1.00
R8672:Gbp11 UTSW 5 105,491,675 (GRCm39) missense probably damaging 1.00
R8858:Gbp11 UTSW 5 105,473,392 (GRCm39) nonsense probably null
R8960:Gbp11 UTSW 5 105,479,251 (GRCm39) missense probably damaging 0.98
R9097:Gbp11 UTSW 5 105,474,347 (GRCm39) makesense probably null
R9232:Gbp11 UTSW 5 105,476,290 (GRCm39) missense possibly damaging 0.76
R9380:Gbp11 UTSW 5 105,475,202 (GRCm39) missense probably benign 0.00
R9400:Gbp11 UTSW 5 105,478,841 (GRCm39) missense probably damaging 1.00
R9438:Gbp11 UTSW 5 105,474,471 (GRCm39) nonsense probably null
Posted On 2015-04-16