Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02158:Mrgpra6'

282306

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgpra6

Ensembl Gene

ENSMUSG00000052303

Gene Name

MAS-related GPR, member A6

Synonyms

MrgA6

Accession Numbers

Genbank: NM_205821; MGI: 3033107

Is this an essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL02158

Quality Score

Status

Chromosome

Chromosomal Location

47185707-47204920 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 47185952 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 240 (Y240*)

Ref Sequence

ENSEMBL: ENSMUSP00000073463 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073793] [ENSMUST00000186456]

Predicted Effect

probably null
Transcript: ENSMUST00000073793
AA Change: Y240*

SMART Domains

Protein: ENSMUSP00000073463
Gene: ENSMUSG00000052303
AA Change: Y240*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	17	198	5.9e-8	PFAM
Pfam:7tm_1	26	258	5.2e-14	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000186456
AA Change: I271N

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000140353
Gene: ENSMUSG00000052303
AA Change: I271N

Domain	Start	End	E-Value	Type
low complexity region	13	26	N/A	INTRINSIC
Pfam:7TM_GPCR_Srx	48	228	1.1e-5	PFAM
Pfam:7tm_1	57	270	1e-15	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	A	T	9: 57,256,619		probably null	Het
Abca2	A	G	2: 25,447,879		probably benign	Het
Abcb11	A	T	2: 69,299,925	S262R	probably damaging	Het
Abhd12	T	A	2: 150,848,421	Q118L	probably benign	Het
Adam1a	A	T	5: 121,518,971	L753*	probably null	Het
Ahctf1	A	T	1: 179,779,652	I699N	possibly damaging	Het
Arl11	C	A	14: 61,311,038	A99E	probably damaging	Het
Atp5o	G	A	16: 91,930,401	R16W	probably damaging	Het
AW551984	T	C	9: 39,599,325	H238R	probably null	Het
Bpifb9a	C	A	2: 154,266,813		probably benign	Het
Carhsp1	A	G	16: 8,663,713		probably benign	Het
Ccdc33	T	C	9: 58,030,419	D623G	probably damaging	Het
Chd6	C	A	2: 161,026,292	R378L	possibly damaging	Het
Chn2	T	C	6: 54,300,245		probably benign	Het
Clgn	T	G	8: 83,423,136	I422S	probably damaging	Het
Col15a1	T	A	4: 47,300,606		probably null	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Cyp2c39	T	C	19: 39,568,130	I470T	probably benign	Het
Dcaf11	T	A	14: 55,564,523		probably null	Het
Dnah1	G	T	14: 31,300,967	T1071K	probably benign	Het
Dnah2	T	A	11: 69,458,123	M2513L	probably benign	Het
Dqx1	A	G	6: 83,058,910		probably benign	Het
Gm1587	T	C	14: 77,798,842	E8G	unknown	Het
Hydin	T	C	8: 110,609,966	I5125T	possibly damaging	Het
Ighv5-9	G	T	12: 113,661,943	P60Q	probably damaging	Het
Itga7	T	G	10: 128,953,782	L993R	possibly damaging	Het
Itpr3	A	G	17: 27,098,442	N857S	probably damaging	Het
Krt23	C	T	11: 99,492,664		probably benign	Het
Lrp1	T	C	10: 127,554,271	N3093S	probably benign	Het
Mms22l	T	C	4: 24,505,349	F203S	probably damaging	Het
Morn5	A	G	2: 36,057,076	D122G	probably damaging	Het
Mpp2	G	T	11: 102,063,262	L220I	probably benign	Het
Mtmr12	T	C	15: 12,237,930	I165T	probably damaging	Het
Mylk2	C	A	2: 152,919,157	N428K	probably damaging	Het
Nfil3	A	G	13: 52,968,152	Y239H	probably damaging	Het
Notch1	A	G	2: 26,460,339	L2263P	probably damaging	Het
Olfr130	T	A	17: 38,067,267	I32N	probably damaging	Het
Olfr888	A	G	9: 38,109,129	M148V	probably benign	Het
P3h3	A	T	6: 124,853,092	Y387N	probably damaging	Het
Pdcd6ip	A	T	9: 113,680,053	Y324*	probably null	Het
Plcb2	C	A	2: 118,711,363	R922L	probably benign	Het
Pml	T	C	9: 58,247,003	T196A	probably benign	Het
Ppp2r1b	C	A	9: 50,861,609	Q65K	probably benign	Het
Ric8a	A	G	7: 140,862,357	T507A	probably benign	Het
Sec16a	A	G	2: 26,416,632		probably null	Het
Slc46a3	G	T	5: 147,886,234	T266N	probably damaging	Het
Smg1	A	G	7: 118,212,946	S41P	possibly damaging	Het
Snrnp200	T	A	2: 127,237,483	N1837K	probably benign	Het
Sptan1	A	G	2: 30,030,324	T2318A	probably damaging	Het
St7l	C	T	3: 104,874,832	T175I	possibly damaging	Het
Tmc7	G	A	7: 118,538,211	R703C	probably damaging	Het
Urah	A	G	7: 140,836,886		probably benign	Het
Vmn1r42	A	T	6: 89,845,314	I91N	probably damaging	Het
Yy1	T	A	12: 108,814,599		probably benign	Het

Other mutations in Mrgpra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01645:Mrgpra6	APN	7	47185933	missense	probably benign	0.00
IGL01780:Mrgpra6	APN	7	47188749	missense	probably damaging	1.00
IGL01801:Mrgpra6	APN	7	47185824	missense	possibly damaging	0.90
IGL02715:Mrgpra6	APN	7	47188648	splice site	probably benign
IGL02896:Mrgpra6	APN	7	47188907	missense	probably benign	0.02
D4216:Mrgpra6	UTSW	7	47188756	missense	probably damaging	0.96
R1566:Mrgpra6	UTSW	7	47188904	missense	probably benign	0.02
R4016:Mrgpra6	UTSW	7	47188715	missense	possibly damaging	0.76
R5051:Mrgpra6	UTSW	7	47185942	missense	probably benign	0.00
R5384:Mrgpra6	UTSW	7	47188881	missense	probably damaging	1.00
R5386:Mrgpra6	UTSW	7	47188881	missense	probably damaging	1.00
R5638:Mrgpra6	UTSW	7	47185909	missense	probably damaging	1.00
R5860:Mrgpra6	UTSW	7	47189351	missense	probably benign	0.41
R6633:Mrgpra6	UTSW	7	47188745	missense	possibly damaging	0.89
R6952:Mrgpra6	UTSW	7	47185945	missense	probably benign	0.01
R6980:Mrgpra6	UTSW	7	47188949	missense	probably damaging	0.97
Z1177:Mrgpra6	UTSW	7	47189162	missense	possibly damaging	0.80

Posted On

2015-04-16