Incidental Mutation 'IGL02158:Mrgpra6'
ID282306
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgpra6
Ensembl Gene ENSMUSG00000052303
Gene NameMAS-related GPR, member A6
SynonymsMrgA6
Accession Numbers

Genbank: NM_205821; MGI: 3033107

Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL02158
Quality Score
Status
Chromosome7
Chromosomal Location47185707-47204920 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 47185952 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 240 (Y240*)
Ref Sequence ENSEMBL: ENSMUSP00000073463 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073793] [ENSMUST00000186456]
Predicted Effect probably null
Transcript: ENSMUST00000073793
AA Change: Y240*
SMART Domains Protein: ENSMUSP00000073463
Gene: ENSMUSG00000052303
AA Change: Y240*

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 17 198 5.9e-8 PFAM
Pfam:7tm_1 26 258 5.2e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000186456
AA Change: I271N

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000140353
Gene: ENSMUSG00000052303
AA Change: I271N

DomainStartEndE-ValueType
low complexity region 13 26 N/A INTRINSIC
Pfam:7TM_GPCR_Srx 48 228 1.1e-5 PFAM
Pfam:7tm_1 57 270 1e-15 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik A T 9: 57,256,619 probably null Het
Abca2 A G 2: 25,447,879 probably benign Het
Abcb11 A T 2: 69,299,925 S262R probably damaging Het
Abhd12 T A 2: 150,848,421 Q118L probably benign Het
Adam1a A T 5: 121,518,971 L753* probably null Het
Ahctf1 A T 1: 179,779,652 I699N possibly damaging Het
Arl11 C A 14: 61,311,038 A99E probably damaging Het
Atp5o G A 16: 91,930,401 R16W probably damaging Het
AW551984 T C 9: 39,599,325 H238R probably null Het
Bpifb9a C A 2: 154,266,813 probably benign Het
Carhsp1 A G 16: 8,663,713 probably benign Het
Ccdc33 T C 9: 58,030,419 D623G probably damaging Het
Chd6 C A 2: 161,026,292 R378L possibly damaging Het
Chn2 T C 6: 54,300,245 probably benign Het
Clgn T G 8: 83,423,136 I422S probably damaging Het
Col15a1 T A 4: 47,300,606 probably null Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cyp2c39 T C 19: 39,568,130 I470T probably benign Het
Dcaf11 T A 14: 55,564,523 probably null Het
Dnah1 G T 14: 31,300,967 T1071K probably benign Het
Dnah2 T A 11: 69,458,123 M2513L probably benign Het
Dqx1 A G 6: 83,058,910 probably benign Het
Gm1587 T C 14: 77,798,842 E8G unknown Het
Hydin T C 8: 110,609,966 I5125T possibly damaging Het
Ighv5-9 G T 12: 113,661,943 P60Q probably damaging Het
Itga7 T G 10: 128,953,782 L993R possibly damaging Het
Itpr3 A G 17: 27,098,442 N857S probably damaging Het
Krt23 C T 11: 99,492,664 probably benign Het
Lrp1 T C 10: 127,554,271 N3093S probably benign Het
Mms22l T C 4: 24,505,349 F203S probably damaging Het
Morn5 A G 2: 36,057,076 D122G probably damaging Het
Mpp2 G T 11: 102,063,262 L220I probably benign Het
Mtmr12 T C 15: 12,237,930 I165T probably damaging Het
Mylk2 C A 2: 152,919,157 N428K probably damaging Het
Nfil3 A G 13: 52,968,152 Y239H probably damaging Het
Notch1 A G 2: 26,460,339 L2263P probably damaging Het
Olfr130 T A 17: 38,067,267 I32N probably damaging Het
Olfr888 A G 9: 38,109,129 M148V probably benign Het
P3h3 A T 6: 124,853,092 Y387N probably damaging Het
Pdcd6ip A T 9: 113,680,053 Y324* probably null Het
Plcb2 C A 2: 118,711,363 R922L probably benign Het
Pml T C 9: 58,247,003 T196A probably benign Het
Ppp2r1b C A 9: 50,861,609 Q65K probably benign Het
Ric8a A G 7: 140,862,357 T507A probably benign Het
Sec16a A G 2: 26,416,632 probably null Het
Slc46a3 G T 5: 147,886,234 T266N probably damaging Het
Smg1 A G 7: 118,212,946 S41P possibly damaging Het
Snrnp200 T A 2: 127,237,483 N1837K probably benign Het
Sptan1 A G 2: 30,030,324 T2318A probably damaging Het
St7l C T 3: 104,874,832 T175I possibly damaging Het
Tmc7 G A 7: 118,538,211 R703C probably damaging Het
Urah A G 7: 140,836,886 probably benign Het
Vmn1r42 A T 6: 89,845,314 I91N probably damaging Het
Yy1 T A 12: 108,814,599 probably benign Het
Other mutations in Mrgpra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01645:Mrgpra6 APN 7 47185933 missense probably benign 0.00
IGL01780:Mrgpra6 APN 7 47188749 missense probably damaging 1.00
IGL01801:Mrgpra6 APN 7 47185824 missense possibly damaging 0.90
IGL02715:Mrgpra6 APN 7 47188648 splice site probably benign
IGL02896:Mrgpra6 APN 7 47188907 missense probably benign 0.02
D4216:Mrgpra6 UTSW 7 47188756 missense probably damaging 0.96
R1566:Mrgpra6 UTSW 7 47188904 missense probably benign 0.02
R4016:Mrgpra6 UTSW 7 47188715 missense possibly damaging 0.76
R5051:Mrgpra6 UTSW 7 47185942 missense probably benign 0.00
R5384:Mrgpra6 UTSW 7 47188881 missense probably damaging 1.00
R5386:Mrgpra6 UTSW 7 47188881 missense probably damaging 1.00
R5638:Mrgpra6 UTSW 7 47185909 missense probably damaging 1.00
R5860:Mrgpra6 UTSW 7 47189351 missense probably benign 0.41
R6633:Mrgpra6 UTSW 7 47188745 missense possibly damaging 0.89
R6952:Mrgpra6 UTSW 7 47185945 missense probably benign 0.01
R6980:Mrgpra6 UTSW 7 47188949 missense probably damaging 0.97
Z1177:Mrgpra6 UTSW 7 47189162 missense possibly damaging 0.80
Posted On2015-04-16