Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02158:Mrgpra6'

282306

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mrgpra6

Ensembl Gene

ENSMUSG00000052303

Gene Name

MAS-related GPR, member A6

Synonyms

MrgA6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL02158

Quality Score

Status

Chromosome

Chromosomal Location

46835465-46839164 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 46835700 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 240 (Y240*)

Ref Sequence

ENSEMBL: ENSMUSP00000073463 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073793] [ENSMUST00000186456]

AlphaFold

Q91ZC6

Predicted Effect

probably null
Transcript: ENSMUST00000073793
AA Change: Y240*

SMART Domains

Protein: ENSMUSP00000073463
Gene: ENSMUSG00000052303
AA Change: Y240*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	17	198	5.9e-8	PFAM
Pfam:7tm_1	26	258	5.2e-14	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000186456
AA Change: I271N

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000140353
Gene: ENSMUSG00000052303
AA Change: I271N

Domain	Start	End	E-Value	Type
low complexity region	13	26	N/A	INTRINSIC
Pfam:7TM_GPCR_Srx	48	228	1.1e-5	PFAM
Pfam:7tm_1	57	270	1e-15	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	A	T	9: 57,163,902 (GRCm39)		probably null	Het
Abca2	A	G	2: 25,337,891 (GRCm39)		probably benign	Het
Abcb11	A	T	2: 69,130,269 (GRCm39)	S262R	probably damaging	Het
Abhd12	T	A	2: 150,690,341 (GRCm39)	Q118L	probably benign	Het
Adam1a	A	T	5: 121,657,034 (GRCm39)	L753*	probably null	Het
Ahctf1	A	T	1: 179,607,217 (GRCm39)	I699N	possibly damaging	Het
Arl11	C	A	14: 61,548,487 (GRCm39)	A99E	probably damaging	Het
Atp5po	G	A	16: 91,727,289 (GRCm39)	R16W	probably damaging	Het
AW551984	T	C	9: 39,510,621 (GRCm39)	H238R	probably null	Het
Bpifb9a	C	A	2: 154,108,733 (GRCm39)		probably benign	Het
Carhsp1	A	G	16: 8,481,577 (GRCm39)		probably benign	Het
Ccdc33	T	C	9: 57,937,702 (GRCm39)	D623G	probably damaging	Het
Chd6	C	A	2: 160,868,212 (GRCm39)	R378L	possibly damaging	Het
Chn2	T	C	6: 54,277,230 (GRCm39)		probably benign	Het
Clgn	T	G	8: 84,149,765 (GRCm39)	I422S	probably damaging	Het
Col15a1	T	A	4: 47,300,606 (GRCm39)		probably null	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cyp2c39	T	C	19: 39,556,574 (GRCm39)	I470T	probably benign	Het
Dcaf11	T	A	14: 55,801,980 (GRCm39)		probably null	Het
Dnah1	G	T	14: 31,022,924 (GRCm39)	T1071K	probably benign	Het
Dnah2	T	A	11: 69,348,949 (GRCm39)	M2513L	probably benign	Het
Dqx1	A	G	6: 83,035,891 (GRCm39)		probably benign	Het
Gm1587	T	C	14: 78,036,282 (GRCm39)	E8G	unknown	Het
Hydin	T	C	8: 111,336,598 (GRCm39)	I5125T	possibly damaging	Het
Ighv5-9	G	T	12: 113,625,563 (GRCm39)	P60Q	probably damaging	Het
Itga7	T	G	10: 128,789,651 (GRCm39)	L993R	possibly damaging	Het
Itpr3	A	G	17: 27,317,416 (GRCm39)	N857S	probably damaging	Het
Krt23	C	T	11: 99,383,490 (GRCm39)		probably benign	Het
Lrp1	T	C	10: 127,390,140 (GRCm39)	N3093S	probably benign	Het
Mms22l	T	C	4: 24,505,349 (GRCm39)	F203S	probably damaging	Het
Morn5	A	G	2: 35,947,088 (GRCm39)	D122G	probably damaging	Het
Mpp2	G	T	11: 101,954,088 (GRCm39)	L220I	probably benign	Het
Mtmr12	T	C	15: 12,238,016 (GRCm39)	I165T	probably damaging	Het
Mylk2	C	A	2: 152,761,077 (GRCm39)	N428K	probably damaging	Het
Nfil3	A	G	13: 53,122,188 (GRCm39)	Y239H	probably damaging	Het
Notch1	A	G	2: 26,350,351 (GRCm39)	L2263P	probably damaging	Het
Or2g7	T	A	17: 38,378,158 (GRCm39)	I32N	probably damaging	Het
Or8b101	A	G	9: 38,020,425 (GRCm39)	M148V	probably benign	Het
P3h3	A	T	6: 124,830,055 (GRCm39)	Y387N	probably damaging	Het
Pdcd6ip	A	T	9: 113,509,121 (GRCm39)	Y324*	probably null	Het
Plcb2	C	A	2: 118,541,844 (GRCm39)	R922L	probably benign	Het
Pml	T	C	9: 58,154,286 (GRCm39)	T196A	probably benign	Het
Ppp2r1b	C	A	9: 50,772,909 (GRCm39)	Q65K	probably benign	Het
Ric8a	A	G	7: 140,442,270 (GRCm39)	T507A	probably benign	Het
Sec16a	A	G	2: 26,306,644 (GRCm39)		probably null	Het
Slc46a3	G	T	5: 147,823,044 (GRCm39)	T266N	probably damaging	Het
Smg1	A	G	7: 117,812,169 (GRCm39)	S41P	possibly damaging	Het
Snrnp200	T	A	2: 127,079,403 (GRCm39)	N1837K	probably benign	Het
Sptan1	A	G	2: 29,920,336 (GRCm39)	T2318A	probably damaging	Het
St7l	C	T	3: 104,782,148 (GRCm39)	T175I	possibly damaging	Het
Tmc7	G	A	7: 118,137,434 (GRCm39)	R703C	probably damaging	Het
Urah	A	G	7: 140,416,799 (GRCm39)		probably benign	Het
Vmn1r42	A	T	6: 89,822,296 (GRCm39)	I91N	probably damaging	Het
Yy1	T	A	12: 108,780,525 (GRCm39)		probably benign	Het

Other mutations in Mrgpra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01645:Mrgpra6	APN	7	46,835,681 (GRCm39)	missense	probably benign	0.00
IGL01780:Mrgpra6	APN	7	46,838,497 (GRCm39)	missense	probably damaging	1.00
IGL01801:Mrgpra6	APN	7	46,835,572 (GRCm39)	missense	possibly damaging	0.90
IGL02715:Mrgpra6	APN	7	46,838,396 (GRCm39)	splice site	probably benign
IGL02896:Mrgpra6	APN	7	46,838,655 (GRCm39)	missense	probably benign	0.02
D4216:Mrgpra6	UTSW	7	46,838,504 (GRCm39)	missense	probably damaging	0.96
R1566:Mrgpra6	UTSW	7	46,838,652 (GRCm39)	missense	probably benign	0.02
R4016:Mrgpra6	UTSW	7	46,838,463 (GRCm39)	missense	possibly damaging	0.76
R5051:Mrgpra6	UTSW	7	46,835,690 (GRCm39)	missense	probably benign	0.00
R5384:Mrgpra6	UTSW	7	46,838,629 (GRCm39)	missense	probably damaging	1.00
R5386:Mrgpra6	UTSW	7	46,838,629 (GRCm39)	missense	probably damaging	1.00
R5638:Mrgpra6	UTSW	7	46,835,657 (GRCm39)	missense	probably damaging	1.00
R5860:Mrgpra6	UTSW	7	46,839,099 (GRCm39)	missense	probably benign	0.41
R6633:Mrgpra6	UTSW	7	46,838,493 (GRCm39)	missense	possibly damaging	0.89
R6952:Mrgpra6	UTSW	7	46,835,693 (GRCm39)	missense	probably benign	0.01
R6980:Mrgpra6	UTSW	7	46,838,697 (GRCm39)	missense	probably damaging	0.97
R9455:Mrgpra6	UTSW	7	46,838,967 (GRCm39)	missense	probably damaging	1.00
R9615:Mrgpra6	UTSW	7	46,835,675 (GRCm39)	missense	probably benign	0.06
R9701:Mrgpra6	UTSW	7	46,835,533 (GRCm39)	missense	probably benign	0.00
R9802:Mrgpra6	UTSW	7	46,835,533 (GRCm39)	missense	probably benign	0.00
Z1177:Mrgpra6	UTSW	7	46,838,910 (GRCm39)	missense	possibly damaging	0.80

Posted On

2015-04-16