Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02159:Lrrc41'

282359

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc41

Ensembl Gene

ENSMUSG00000028703

Gene Name

leucine rich repeat containing 41

Synonyms

D730026A16Rik, MUF1, D630045E04Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.494) question?

Stock #

IGL02159

Quality Score

Status

Chromosome

Chromosomal Location

116075269-116097043 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 116088486 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 133 (F133I)

Ref Sequence

ENSEMBL: ENSMUSP00000030471 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030471]

AlphaFold

Q8K1C9

Predicted Effect

probably benign
Transcript: ENSMUST00000030471
AA Change: F133I

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000030471
Gene: ENSMUSG00000028703
AA Change: F133I

Domain	Start	End	E-Value	Type
low complexity region	30	45	N/A	INTRINSIC
low complexity region	280	291	N/A	INTRINSIC
low complexity region	314	325	N/A	INTRINSIC
low complexity region	352	382	N/A	INTRINSIC
low complexity region	417	429	N/A	INTRINSIC
SCOP:d1yrga_	449	742	4e-12	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133799

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134983

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138952

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017N19Rik	T	C	10: 100,610,665 (GRCm38)	L257S	probably damaging	Het
2210010C04Rik	T	C	6: 41,032,957 (GRCm38)	T148A	probably benign	Het
Abca13	A	G	11: 9,314,545 (GRCm38)	S2976G	probably benign	Het
Afmid	T	C	11: 117,836,426 (GRCm38)	W267R	probably damaging	Het
Ahi1	A	G	10: 21,058,177 (GRCm38)	K969R	probably benign	Het
Aldh1l1	A	G	6: 90,594,656 (GRCm38)		probably benign	Het
Ank3	A	G	10: 69,808,892 (GRCm38)	H62R	probably damaging	Het
Arid2	T	C	15: 96,358,912 (GRCm38)		probably benign	Het
BC030867	G	A	11: 102,260,165 (GRCm38)		probably null	Het
Caps2	G	A	10: 112,204,023 (GRCm38)	V457M	probably benign	Het
Capza1	T	C	3: 104,864,371 (GRCm38)	D3G	possibly damaging	Het
Cav1	T	A	6: 17,307,972 (GRCm38)	V41E	possibly damaging	Het
Celf2	G	T	2: 6,604,177 (GRCm38)	C264*	probably null	Het
Clec4a2	C	T	6: 123,139,326 (GRCm38)	S150L	probably benign	Het
D7Ertd443e	A	T	7: 134,349,400 (GRCm38)	D181E	possibly damaging	Het
Epyc	A	G	10: 97,670,631 (GRCm38)	E100G	probably benign	Het
Hdac11	A	G	6: 91,173,102 (GRCm38)	I294M	probably damaging	Het
Hsdl1	A	G	8: 119,566,414 (GRCm38)	V73A	probably benign	Het
Kmt2c	A	T	5: 25,311,343 (GRCm38)	S2501T	probably benign	Het
Map3k19	C	A	1: 127,823,170 (GRCm38)	G815C	probably benign	Het
Muc13	C	A	16: 33,799,479 (GRCm38)	T199K	unknown	Het
Nif3l1	G	T	1: 58,447,946 (GRCm38)		probably null	Het
Nlrp12	A	T	7: 3,249,545 (GRCm38)		probably benign	Het
Nup205	T	C	6: 35,189,178 (GRCm38)	S244P	probably damaging	Het
Olfr1353	A	T	10: 78,969,901 (GRCm38)	N84I	probably damaging	Het
Parl	G	A	16: 20,280,088 (GRCm38)		probably benign	Het
Pax8	A	G	2: 24,440,788 (GRCm38)	I211T	possibly damaging	Het
Pglyrp4	A	G	3: 90,730,853 (GRCm38)	E158G	possibly damaging	Het
Plekhm1	A	G	11: 103,380,231 (GRCm38)	L478P	probably benign	Het
Serpina1a	C	T	12: 103,854,706 (GRCm38)	G338R	probably damaging	Het
Serpina5	T	C	12: 104,105,298 (GRCm38)	L388P	possibly damaging	Het
Sorbs1	A	G	19: 40,327,596 (GRCm38)	V367A	probably damaging	Het
Srgap2	A	G	1: 131,319,666 (GRCm38)		probably benign	Het
Surf1	A	G	2: 26,915,651 (GRCm38)	L26P	probably damaging	Het
Taf4	A	G	2: 179,938,470 (GRCm38)	S486P	probably benign	Het
Tdrd6	A	T	17: 43,628,390 (GRCm38)	V589E	probably damaging	Het
Tuba3b	T	G	6: 145,619,666 (GRCm38)	S287A	probably benign	Het
Txnrd3	G	A	6: 89,669,324 (GRCm38)	R295H	probably damaging	Het
Ubr5	G	T	15: 37,991,379 (GRCm38)		probably benign	Het
Unc45b	C	T	11: 82,940,181 (GRCm38)		probably benign	Het
Usp32	A	G	11: 85,005,802 (GRCm38)		probably null	Het
Utp23	G	A	15: 51,882,365 (GRCm38)	R87K	probably benign	Het
Vps8	T	C	16: 21,466,484 (GRCm38)	I405T	possibly damaging	Het

Other mutations in Lrrc41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01309:Lrrc41	APN	4	116,096,466 (GRCm38)	missense	probably damaging	0.97
IGL01358:Lrrc41	APN	4	116,075,587 (GRCm38)	missense	probably benign	0.16
IGL01734:Lrrc41	APN	4	116,093,134 (GRCm38)	critical splice donor site	probably null
IGL01986:Lrrc41	APN	4	116,089,322 (GRCm38)	missense	probably benign	0.27
IGL02892:Lrrc41	APN	4	116,088,835 (GRCm38)	missense	possibly damaging	0.68
IGL03135:Lrrc41	APN	4	116,088,531 (GRCm38)	missense	probably benign
R1478:Lrrc41	UTSW	4	116,095,208 (GRCm38)	nonsense	probably null
R1765:Lrrc41	UTSW	4	116,089,051 (GRCm38)	missense	possibly damaging	0.94
R2233:Lrrc41	UTSW	4	116,096,385 (GRCm38)	missense	possibly damaging	0.66
R4080:Lrrc41	UTSW	4	116,080,546 (GRCm38)	splice site	probably null
R4677:Lrrc41	UTSW	4	116,095,135 (GRCm38)	missense	probably benign
R4833:Lrrc41	UTSW	4	116,093,177 (GRCm38)	unclassified	probably benign
R4877:Lrrc41	UTSW	4	116,079,405 (GRCm38)	missense	probably damaging	0.99
R4926:Lrrc41	UTSW	4	116,089,324 (GRCm38)	missense	possibly damaging	0.46
R6459:Lrrc41	UTSW	4	116,088,780 (GRCm38)	missense	possibly damaging	0.95
R6817:Lrrc41	UTSW	4	116,089,305 (GRCm38)	missense	possibly damaging	0.66
R6834:Lrrc41	UTSW	4	116,096,529 (GRCm38)	missense	possibly damaging	0.46
R7479:Lrrc41	UTSW	4	116,089,041 (GRCm38)	missense	probably damaging	0.96
R7512:Lrrc41	UTSW	4	116,092,994 (GRCm38)	missense	possibly damaging	0.66
R7593:Lrrc41	UTSW	4	116,092,944 (GRCm38)	missense	possibly damaging	0.94
R8006:Lrrc41	UTSW	4	116,094,888 (GRCm38)	missense	possibly damaging	0.79
R8810:Lrrc41	UTSW	4	116,075,291 (GRCm38)	unclassified	probably benign
R9134:Lrrc41	UTSW	4	116,088,585 (GRCm38)	missense	possibly damaging	0.89
R9495:Lrrc41	UTSW	4	116,075,609 (GRCm38)	critical splice donor site	probably null

Posted On

2015-04-16