Incidental Mutation 'IGL02159:Hdac11'
ID 282361
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hdac11
Ensembl Gene ENSMUSG00000034245
Gene Name histone deacetylase 11
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.423) question?
Stock # IGL02159
Quality Score
Chromosome 6
Chromosomal Location 91156665-91174692 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 91173102 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 294 (I294M)
Ref Sequence ENSEMBL: ENSMUSP00000043828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041736] [ENSMUST00000204776]
AlphaFold Q91WA3
Predicted Effect probably damaging
Transcript: ENSMUST00000041736
AA Change: I294M

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000043828
Gene: ENSMUSG00000034245
AA Change: I294M

Pfam:Hist_deacetyl 24 321 1e-51 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134154
Predicted Effect probably benign
Transcript: ENSMUST00000155007
SMART Domains Protein: ENSMUSP00000120923
Gene: ENSMUSG00000034245

SCOP:d1c3pa_ 14 122 8e-16 SMART
low complexity region 124 140 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000204776
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205134
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
PHENOTYPE: Mice homozygous for a knockout allele exhibit increased IL10 secretion from peritoneal elicited macrophages stimulated with LPS, more suppressive myeloid-derived suppressive cell population and enhanced tumor growth of injected tumor cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T C 10: 100,610,665 L257S probably damaging Het
2210010C04Rik T C 6: 41,032,957 T148A probably benign Het
Abca13 A G 11: 9,314,545 S2976G probably benign Het
Afmid T C 11: 117,836,426 W267R probably damaging Het
Ahi1 A G 10: 21,058,177 K969R probably benign Het
Aldh1l1 A G 6: 90,594,656 probably benign Het
Ank3 A G 10: 69,808,892 H62R probably damaging Het
Arid2 T C 15: 96,358,912 probably benign Het
BC030867 G A 11: 102,260,165 probably null Het
Caps2 G A 10: 112,204,023 V457M probably benign Het
Capza1 T C 3: 104,864,371 D3G possibly damaging Het
Cav1 T A 6: 17,307,972 V41E possibly damaging Het
Celf2 G T 2: 6,604,177 C264* probably null Het
Clec4a2 C T 6: 123,139,326 S150L probably benign Het
D7Ertd443e A T 7: 134,349,400 D181E possibly damaging Het
Epyc A G 10: 97,670,631 E100G probably benign Het
Hsdl1 A G 8: 119,566,414 V73A probably benign Het
Kmt2c A T 5: 25,311,343 S2501T probably benign Het
Lrrc41 T A 4: 116,088,486 F133I probably benign Het
Map3k19 C A 1: 127,823,170 G815C probably benign Het
Muc13 C A 16: 33,799,479 T199K unknown Het
Nif3l1 G T 1: 58,447,946 probably null Het
Nlrp12 A T 7: 3,249,545 probably benign Het
Nup205 T C 6: 35,189,178 S244P probably damaging Het
Olfr1353 A T 10: 78,969,901 N84I probably damaging Het
Parl G A 16: 20,280,088 probably benign Het
Pax8 A G 2: 24,440,788 I211T possibly damaging Het
Pglyrp4 A G 3: 90,730,853 E158G possibly damaging Het
Plekhm1 A G 11: 103,380,231 L478P probably benign Het
Serpina1a C T 12: 103,854,706 G338R probably damaging Het
Serpina5 T C 12: 104,105,298 L388P possibly damaging Het
Sorbs1 A G 19: 40,327,596 V367A probably damaging Het
Srgap2 A G 1: 131,319,666 probably benign Het
Surf1 A G 2: 26,915,651 L26P probably damaging Het
Taf4 A G 2: 179,938,470 S486P probably benign Het
Tdrd6 A T 17: 43,628,390 V589E probably damaging Het
Tuba3b T G 6: 145,619,666 S287A probably benign Het
Txnrd3 G A 6: 89,669,324 R295H probably damaging Het
Ubr5 G T 15: 37,991,379 probably benign Het
Unc45b C T 11: 82,940,181 probably benign Het
Usp32 A G 11: 85,005,802 probably null Het
Utp23 G A 15: 51,882,365 R87K probably benign Het
Vps8 T C 16: 21,466,484 I405T possibly damaging Het
Other mutations in Hdac11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01452:Hdac11 APN 6 91167861 missense probably damaging 1.00
IGL01556:Hdac11 APN 6 91173180 missense probably benign 0.00
IGL03082:Hdac11 APN 6 91173103 missense probably damaging 1.00
IGL03046:Hdac11 UTSW 6 91168845 missense probably benign 0.02
R1791:Hdac11 UTSW 6 91168824 missense probably benign
R5771:Hdac11 UTSW 6 91169382 splice site probably null
R5877:Hdac11 UTSW 6 91157542 missense probably damaging 1.00
R5974:Hdac11 UTSW 6 91173214 missense probably benign
R6803:Hdac11 UTSW 6 91166265 missense probably damaging 0.97
R7483:Hdac11 UTSW 6 91159232 missense probably damaging 0.99
R7786:Hdac11 UTSW 6 91173176 nonsense probably null
R8259:Hdac11 UTSW 6 91172228 missense probably damaging 1.00
R8990:Hdac11 UTSW 6 91168817 nonsense probably null
R9681:Hdac11 UTSW 6 91173086 missense probably benign 0.11
Z1177:Hdac11 UTSW 6 91167834 missense possibly damaging 0.64
Posted On 2015-04-16