Incidental Mutation 'IGL02159:Olfr1353'
ID 282364
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1353
Ensembl Gene ENSMUSG00000042774
Gene Name olfactory receptor 1353
Synonyms GA_x6K02T2QGN0-2842591-2841662, MOR139-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock # IGL02159
Quality Score
Status
Chromosome 10
Chromosomal Location 78963309-78971338 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 78969901 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 84 (N84I)
Ref Sequence ENSEMBL: ENSMUSP00000145073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039718] [ENSMUST00000204849] [ENSMUST00000205193]
AlphaFold Q8VGU8
Predicted Effect probably damaging
Transcript: ENSMUST00000039718
AA Change: N84I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000038992
Gene: ENSMUSG00000042774
AA Change: N84I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204849
AA Change: N84I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145454
Gene: ENSMUSG00000042774
AA Change: N84I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205193
AA Change: N84I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: N84I

DomainStartEndE-ValueType
Pfam:7tm_4 31 95 5.8e-10 PFAM
Pfam:7tm_1 41 94 3.5e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T C 10: 100,610,665 L257S probably damaging Het
2210010C04Rik T C 6: 41,032,957 T148A probably benign Het
Abca13 A G 11: 9,314,545 S2976G probably benign Het
Afmid T C 11: 117,836,426 W267R probably damaging Het
Ahi1 A G 10: 21,058,177 K969R probably benign Het
Aldh1l1 A G 6: 90,594,656 probably benign Het
Ank3 A G 10: 69,808,892 H62R probably damaging Het
Arid2 T C 15: 96,358,912 probably benign Het
BC030867 G A 11: 102,260,165 probably null Het
Caps2 G A 10: 112,204,023 V457M probably benign Het
Capza1 T C 3: 104,864,371 D3G possibly damaging Het
Cav1 T A 6: 17,307,972 V41E possibly damaging Het
Celf2 G T 2: 6,604,177 C264* probably null Het
Clec4a2 C T 6: 123,139,326 S150L probably benign Het
D7Ertd443e A T 7: 134,349,400 D181E possibly damaging Het
Epyc A G 10: 97,670,631 E100G probably benign Het
Hdac11 A G 6: 91,173,102 I294M probably damaging Het
Hsdl1 A G 8: 119,566,414 V73A probably benign Het
Kmt2c A T 5: 25,311,343 S2501T probably benign Het
Lrrc41 T A 4: 116,088,486 F133I probably benign Het
Map3k19 C A 1: 127,823,170 G815C probably benign Het
Muc13 C A 16: 33,799,479 T199K unknown Het
Nif3l1 G T 1: 58,447,946 probably null Het
Nlrp12 A T 7: 3,249,545 probably benign Het
Nup205 T C 6: 35,189,178 S244P probably damaging Het
Parl G A 16: 20,280,088 probably benign Het
Pax8 A G 2: 24,440,788 I211T possibly damaging Het
Pglyrp4 A G 3: 90,730,853 E158G possibly damaging Het
Plekhm1 A G 11: 103,380,231 L478P probably benign Het
Serpina1a C T 12: 103,854,706 G338R probably damaging Het
Serpina5 T C 12: 104,105,298 L388P possibly damaging Het
Sorbs1 A G 19: 40,327,596 V367A probably damaging Het
Srgap2 A G 1: 131,319,666 probably benign Het
Surf1 A G 2: 26,915,651 L26P probably damaging Het
Taf4 A G 2: 179,938,470 S486P probably benign Het
Tdrd6 A T 17: 43,628,390 V589E probably damaging Het
Tuba3b T G 6: 145,619,666 S287A probably benign Het
Txnrd3 G A 6: 89,669,324 R295H probably damaging Het
Ubr5 G T 15: 37,991,379 probably benign Het
Unc45b C T 11: 82,940,181 probably benign Het
Usp32 A G 11: 85,005,802 probably null Het
Utp23 G A 15: 51,882,365 R87K probably benign Het
Vps8 T C 16: 21,466,484 I405T possibly damaging Het
Other mutations in Olfr1353
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Olfr1353 APN 10 78970106 missense probably damaging 1.00
R0355:Olfr1353 UTSW 10 78970433 missense probably damaging 1.00
R0561:Olfr1353 UTSW 10 78969895 nonsense probably null
R1305:Olfr1353 UTSW 10 78970099 missense probably benign 0.03
R1921:Olfr1353 UTSW 10 78970141 nonsense probably null
R1922:Olfr1353 UTSW 10 78970141 nonsense probably null
R2382:Olfr1353 UTSW 10 78970156 missense probably damaging 0.99
R2920:Olfr1353 UTSW 10 78970012 missense probably damaging 1.00
R4491:Olfr1353 UTSW 10 78970317 missense probably damaging 1.00
R5113:Olfr1353 UTSW 10 78970203 missense probably benign
R5305:Olfr1353 UTSW 10 78970556 missense possibly damaging 0.68
R5744:Olfr1353 UTSW 10 78970183 missense probably damaging 1.00
R5861:Olfr1353 UTSW 10 78969931 missense probably damaging 1.00
R6197:Olfr1353 UTSW 10 78970140 missense probably damaging 1.00
R6314:Olfr1353 UTSW 10 78970345 missense probably benign
R7693:Olfr1353 UTSW 10 78970303 missense probably damaging 1.00
Posted On 2015-04-16