Incidental Mutation 'IGL02159:Pglyrp4'
ID 282378
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp4
Ensembl Gene ENSMUSG00000042250
Gene Name peptidoglycan recognition protein 4
Synonyms LOC384997, LOC242097
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02159
Quality Score
Status
Chromosome 3
Chromosomal Location 90726906-90741517 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 90730853 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 158 (E158G)
Ref Sequence ENSEMBL: ENSMUSP00000040755 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047745] [ENSMUST00000169698]
AlphaFold Q0VB07
Predicted Effect possibly damaging
Transcript: ENSMUST00000047745
AA Change: E158G

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000040755
Gene: ENSMUSG00000042250
AA Change: E158G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 213 1.14e-7 SMART
PGRP 212 353 2.13e-72 SMART
Ami_2 222 359 1.62e-21 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000169698
AA Change: E158G

PolyPhen 2 Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000128113
Gene: ENSMUSG00000042250
AA Change: E158G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PGRP 55 196 1.5e-58 SMART
Ami_2 66 200 2.12e-7 SMART
PGRP 213 354 2.13e-72 SMART
Ami_2 223 360 1.62e-21 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T C 10: 100,610,665 L257S probably damaging Het
2210010C04Rik T C 6: 41,032,957 T148A probably benign Het
Abca13 A G 11: 9,314,545 S2976G probably benign Het
Afmid T C 11: 117,836,426 W267R probably damaging Het
Ahi1 A G 10: 21,058,177 K969R probably benign Het
Aldh1l1 A G 6: 90,594,656 probably benign Het
Ank3 A G 10: 69,808,892 H62R probably damaging Het
Arid2 T C 15: 96,358,912 probably benign Het
BC030867 G A 11: 102,260,165 probably null Het
Caps2 G A 10: 112,204,023 V457M probably benign Het
Capza1 T C 3: 104,864,371 D3G possibly damaging Het
Cav1 T A 6: 17,307,972 V41E possibly damaging Het
Celf2 G T 2: 6,604,177 C264* probably null Het
Clec4a2 C T 6: 123,139,326 S150L probably benign Het
D7Ertd443e A T 7: 134,349,400 D181E possibly damaging Het
Epyc A G 10: 97,670,631 E100G probably benign Het
Hdac11 A G 6: 91,173,102 I294M probably damaging Het
Hsdl1 A G 8: 119,566,414 V73A probably benign Het
Kmt2c A T 5: 25,311,343 S2501T probably benign Het
Lrrc41 T A 4: 116,088,486 F133I probably benign Het
Map3k19 C A 1: 127,823,170 G815C probably benign Het
Muc13 C A 16: 33,799,479 T199K unknown Het
Nif3l1 G T 1: 58,447,946 probably null Het
Nlrp12 A T 7: 3,249,545 probably benign Het
Nup205 T C 6: 35,189,178 S244P probably damaging Het
Olfr1353 A T 10: 78,969,901 N84I probably damaging Het
Parl G A 16: 20,280,088 probably benign Het
Pax8 A G 2: 24,440,788 I211T possibly damaging Het
Plekhm1 A G 11: 103,380,231 L478P probably benign Het
Serpina1a C T 12: 103,854,706 G338R probably damaging Het
Serpina5 T C 12: 104,105,298 L388P possibly damaging Het
Sorbs1 A G 19: 40,327,596 V367A probably damaging Het
Srgap2 A G 1: 131,319,666 probably benign Het
Surf1 A G 2: 26,915,651 L26P probably damaging Het
Taf4 A G 2: 179,938,470 S486P probably benign Het
Tdrd6 A T 17: 43,628,390 V589E probably damaging Het
Tuba3b T G 6: 145,619,666 S287A probably benign Het
Txnrd3 G A 6: 89,669,324 R295H probably damaging Het
Ubr5 G T 15: 37,991,379 probably benign Het
Unc45b C T 11: 82,940,181 probably benign Het
Usp32 A G 11: 85,005,802 probably null Het
Utp23 G A 15: 51,882,365 R87K probably benign Het
Vps8 T C 16: 21,466,484 I405T possibly damaging Het
Other mutations in Pglyrp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Pglyrp4 APN 3 90739028 missense probably damaging 1.00
IGL00575:Pglyrp4 APN 3 90730791 missense probably damaging 1.00
IGL01892:Pglyrp4 APN 3 90739041 missense probably benign 0.00
IGL02097:Pglyrp4 APN 3 90735603 missense probably benign 0.01
IGL02398:Pglyrp4 APN 3 90739117 splice site probably benign
IGL02565:Pglyrp4 APN 3 90735487 missense probably benign
IGL02619:Pglyrp4 APN 3 90735648 splice site probably null
R1160:Pglyrp4 UTSW 3 90728831 splice site probably null
R1420:Pglyrp4 UTSW 3 90728714 missense probably damaging 0.96
R1828:Pglyrp4 UTSW 3 90733003 missense probably damaging 1.00
R4974:Pglyrp4 UTSW 3 90733007 missense probably benign 0.04
R5268:Pglyrp4 UTSW 3 90726964 missense probably damaging 1.00
R5704:Pglyrp4 UTSW 3 90740274 splice site probably null
R7286:Pglyrp4 UTSW 3 90732974 missense probably damaging 1.00
R7787:Pglyrp4 UTSW 3 90732988 missense probably damaging 1.00
R8772:Pglyrp4 UTSW 3 90740400 missense possibly damaging 0.54
R9132:Pglyrp4 UTSW 3 90727931 nonsense probably null
R9607:Pglyrp4 UTSW 3 90730844 missense probably damaging 1.00
Z1176:Pglyrp4 UTSW 3 90739005 missense probably damaging 1.00
Posted On 2015-04-16