Incidental Mutation 'IGL00970:Prr23a2'
ID28246
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prr23a2
Ensembl Gene ENSMUSG00000063058
Gene Nameproline rich 23A, member 2
SynonymsGm6406
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock #IGL00970
Quality Score
Status
Chromosome9
Chromosomal Location98856494-98857374 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 98856961 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 124 (D124G)
Ref Sequence ENSEMBL: ENSMUSP00000071270 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071302]
Predicted Effect probably benign
Transcript: ENSMUST00000071302
AA Change: D124G

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000071270
Gene: ENSMUSG00000063058
AA Change: D124G

DomainStartEndE-ValueType
Pfam:DUF2476 2 250 1.5e-92 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833427G06Rik T A 9: 51,083,586 K148* probably null Het
Adamts19 T A 18: 59,011,077 N910K possibly damaging Het
Atp8b5 A G 4: 43,311,938 T184A probably benign Het
Cabp7 T C 11: 4,738,931 I180V probably benign Het
Casp8ap2 A G 4: 32,646,182 T1752A probably benign Het
Dgkb T C 12: 38,190,083 L453P probably damaging Het
Disp2 A C 2: 118,791,793 D1002A probably damaging Het
Eif3c G A 7: 126,559,008 P259S probably benign Het
Fam227b A T 2: 126,127,060 D31E probably benign Het
Farp2 T C 1: 93,560,327 V92A probably benign Het
Fhod1 C A 8: 105,332,102 V745L possibly damaging Het
Gm8994 A G 6: 136,329,111 D169G probably damaging Het
Gprin3 T C 6: 59,353,837 E495G possibly damaging Het
Grm5 T C 7: 87,803,896 I247T probably damaging Het
Herc2 T C 7: 56,181,064 probably benign Het
Hspg2 C A 4: 137,542,590 Q2311K probably benign Het
Krt26 T C 11: 99,331,281 Y400C probably benign Het
Lct A T 1: 128,304,068 D681E probably damaging Het
Lgalsl G T 11: 20,826,493 P133Q probably benign Het
Man2b2 C T 5: 36,816,143 W76* probably null Het
Mylk4 T C 13: 32,715,922 E326G probably damaging Het
Odam T G 5: 87,886,608 probably benign Het
Pabpc4 T C 4: 123,286,815 I110T probably damaging Het
Pcdh15 A T 10: 74,379,340 D47V probably damaging Het
Plekhg4 C T 8: 105,378,435 R577C probably benign Het
Pnpo C A 11: 96,943,792 C26F possibly damaging Het
Polg T C 7: 79,451,745 I1071M probably benign Het
Rexo1 C T 10: 80,550,964 V87I probably damaging Het
Robo2 C A 16: 73,897,046 V1502L probably benign Het
Ruvbl2 A G 7: 45,429,570 L50P possibly damaging Het
Ryr3 T C 2: 112,764,676 K2534E probably damaging Het
Scfd2 T C 5: 74,530,934 H229R possibly damaging Het
Sesn3 A G 9: 14,321,142 D237G probably damaging Het
Shank1 T C 7: 44,354,238 S1785P possibly damaging Het
Slc11a1 A G 1: 74,380,662 T165A probably damaging Het
Star G A 8: 25,812,866 probably null Het
Trpc6 A T 9: 8,653,151 N575Y probably damaging Het
Unc5d T C 8: 28,696,428 T598A probably benign Het
Vmn1r200 A T 13: 22,395,723 Q232L probably damaging Het
Wdr31 T C 4: 62,457,520 T233A probably damaging Het
Zzef1 G A 11: 72,915,245 R2669Q probably benign Het
Other mutations in Prr23a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01867:Prr23a2 APN 9 98857060 missense probably benign
R0542:Prr23a2 UTSW 9 98857033 missense probably benign 0.00
R0566:Prr23a2 UTSW 9 98856988 missense possibly damaging 0.95
R0831:Prr23a2 UTSW 9 98856864 missense probably damaging 1.00
R5382:Prr23a2 UTSW 9 98857176 missense probably damaging 1.00
R7309:Prr23a2 UTSW 9 98856974 missense probably benign 0.43
Posted On2013-04-17