Incidental Mutation 'IGL02161:Ccr1l1'
ID282487
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccr1l1
Ensembl Gene ENSMUSG00000064039
Gene Namechemokine (C-C motif) receptor 1-like 1
SynonymsMIP-1 alphaRL1, Cmkbr1l1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02161
Quality Score
Status
Chromosome9
Chromosomal Location123977243-123978408 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 123977963 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 149 (T149I)
Ref Sequence ENSEMBL: ENSMUSP00000071353 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071404]
Predicted Effect possibly damaging
Transcript: ENSMUST00000071404
AA Change: T149I

PolyPhen 2 Score 0.868 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000071353
Gene: ENSMUSG00000064039
AA Change: T149I

DomainStartEndE-ValueType
Pfam:7tm_1 52 302 6.6e-42 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A T 12: 118,874,755 V1024D probably benign Het
Alox5 T A 6: 116,423,193 M262L probably benign Het
Arid5b T C 10: 68,096,668 T1135A probably benign Het
Ascc3 T A 10: 50,850,527 Y2177* probably null Het
Birc6 A C 17: 74,548,837 H214P probably damaging Het
Catsperb T A 12: 101,409,415 probably benign Het
Cfap57 T G 4: 118,579,372 R942S possibly damaging Het
Crocc G A 4: 141,033,991 A941V probably benign Het
Csde1 A G 3: 103,050,338 Q471R probably damaging Het
Csmd1 C T 8: 16,358,412 V380I probably damaging Het
Dhx8 A T 11: 101,757,606 Q857L probably damaging Het
Eftud2 A G 11: 102,854,876 probably benign Het
Fat3 C A 9: 15,997,050 R2552I probably benign Het
Fat3 T A 9: 15,997,051 R2552* probably null Het
Fbln7 A T 2: 128,889,791 K166I probably benign Het
Glrx2 C T 1: 143,739,683 S8L possibly damaging Het
Grin2d T G 7: 45,854,422 I630L possibly damaging Het
Gsap T A 5: 21,253,379 W423R probably damaging Het
Kifc2 A G 15: 76,666,045 E468G probably damaging Het
Kpnb1 A G 11: 97,168,936 S566P probably benign Het
Lemd2 A G 17: 27,190,651 S509P probably damaging Het
Lepr T C 4: 101,745,678 F221S probably damaging Het
Nynrin T C 14: 55,863,984 F370S probably damaging Het
Olfr642 C A 7: 104,049,590 V255L possibly damaging Het
Pcdhb15 T A 18: 37,475,502 S596T possibly damaging Het
Prkcq G T 2: 11,277,076 S472I probably benign Het
Rabgef1 T C 5: 130,207,099 probably benign Het
Rnd3 C T 2: 51,134,076 V164M probably benign Het
Rtn4rl1 G A 11: 75,265,840 R366Q probably damaging Het
Sesn2 A T 4: 132,496,918 I393N probably damaging Het
St8sia2 T C 7: 73,976,682 N46S probably benign Het
Svopl A G 6: 38,036,815 probably benign Het
Tbr1 C T 2: 61,805,239 Q178* probably null Het
Vax2 T C 6: 83,737,903 S267P probably damaging Het
Vmn1r47 T A 6: 90,022,316 Y143* probably null Het
Vmn2r28 A G 7: 5,488,124 S375P possibly damaging Het
Vmn2r44 A T 7: 8,377,815 Y360N possibly damaging Het
Zc3h6 G A 2: 128,993,226 S94N possibly damaging Het
Other mutations in Ccr1l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00807:Ccr1l1 APN 9 123977469 missense probably benign
IGL02293:Ccr1l1 APN 9 123977936 missense possibly damaging 0.87
IGL03179:Ccr1l1 APN 9 123977750 missense probably damaging 1.00
IGL03294:Ccr1l1 APN 9 123978407 start codon destroyed probably null 0.56
R1672:Ccr1l1 UTSW 9 123977507 missense probably damaging 1.00
R2165:Ccr1l1 UTSW 9 123977654 missense probably damaging 1.00
R2170:Ccr1l1 UTSW 9 123978135 missense possibly damaging 0.79
R2886:Ccr1l1 UTSW 9 123977516 missense probably damaging 1.00
R4834:Ccr1l1 UTSW 9 123977705 missense probably damaging 1.00
R5598:Ccr1l1 UTSW 9 123977993 missense probably benign
R6458:Ccr1l1 UTSW 9 123978166 missense probably damaging 1.00
X0019:Ccr1l1 UTSW 9 123977789 missense probably damaging 1.00
Z1088:Ccr1l1 UTSW 9 123977850 missense probably benign
Posted On2015-04-16