Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02161:Svopl'

282495

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Svopl

Ensembl Gene

ENSMUSG00000029830

Gene Name

SV2 related protein homolog (rat)-like

Synonyms

9430071P14Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02161

Quality Score

Status

Chromosome

Chromosomal Location

37960674-38023931 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 38013750 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000093743 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000096040]

AlphaFold

Q6PDF3

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000040486

Predicted Effect

probably benign
Transcript: ENSMUST00000096040

SMART Domains

Protein: ENSMUSP00000093743
Gene: ENSMUSG00000029830

Domain	Start	End	E-Value	Type
Pfam:Sugar_tr	17	297	5.5e-20	PFAM
Pfam:MFS_1	50	308	2.1e-20	PFAM
transmembrane domain	349	371	N/A	INTRINSIC
transmembrane domain	384	406	N/A	INTRINSIC
transmembrane domain	459	481	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	A	T	12: 118,838,490 (GRCm39)	V1024D	probably benign	Het
Alox5	T	A	6: 116,400,154 (GRCm39)	M262L	probably benign	Het
Arid5b	T	C	10: 67,932,498 (GRCm39)	T1135A	probably benign	Het
Ascc3	T	A	10: 50,726,623 (GRCm39)	Y2177*	probably null	Het
Birc6	A	C	17: 74,855,832 (GRCm39)	H214P	probably damaging	Het
Catsperb	T	A	12: 101,375,674 (GRCm39)		probably benign	Het
Ccr1l1	G	A	9: 123,778,000 (GRCm39)	T149I	possibly damaging	Het
Cfap57	T	G	4: 118,436,569 (GRCm39)	R942S	possibly damaging	Het
Crocc	G	A	4: 140,761,302 (GRCm39)	A941V	probably benign	Het
Csde1	A	G	3: 102,957,654 (GRCm39)	Q471R	probably damaging	Het
Csmd1	C	T	8: 16,408,426 (GRCm39)	V380I	probably damaging	Het
Dhx8	A	T	11: 101,648,432 (GRCm39)	Q857L	probably damaging	Het
Eftud2	A	G	11: 102,745,702 (GRCm39)		probably benign	Het
Fat3	C	A	9: 15,908,346 (GRCm39)	R2552I	probably benign	Het
Fat3	T	A	9: 15,908,347 (GRCm39)	R2552*	probably null	Het
Fbln7	A	T	2: 128,731,711 (GRCm39)	K166I	probably benign	Het
Glrx2	C	T	1: 143,615,421 (GRCm39)	S8L	possibly damaging	Het
Grin2d	T	G	7: 45,503,846 (GRCm39)	I630L	possibly damaging	Het
Gsap	T	A	5: 21,458,377 (GRCm39)	W423R	probably damaging	Het
Kifc2	A	G	15: 76,550,245 (GRCm39)	E468G	probably damaging	Het
Kpnb1	A	G	11: 97,059,762 (GRCm39)	S566P	probably benign	Het
Lemd2	A	G	17: 27,409,625 (GRCm39)	S509P	probably damaging	Het
Lepr	T	C	4: 101,602,875 (GRCm39)	F221S	probably damaging	Het
Nynrin	T	C	14: 56,101,441 (GRCm39)	F370S	probably damaging	Het
Or51a10	C	A	7: 103,698,797 (GRCm39)	V255L	possibly damaging	Het
Pcdhb15	T	A	18: 37,608,555 (GRCm39)	S596T	possibly damaging	Het
Prkcq	G	T	2: 11,281,887 (GRCm39)	S472I	probably benign	Het
Rabgef1	T	C	5: 130,235,940 (GRCm39)		probably benign	Het
Rnd3	C	T	2: 51,024,088 (GRCm39)	V164M	probably benign	Het
Rtn4rl1	G	A	11: 75,156,666 (GRCm39)	R366Q	probably damaging	Het
Sesn2	A	T	4: 132,224,229 (GRCm39)	I393N	probably damaging	Het
St8sia2	T	C	7: 73,626,430 (GRCm39)	N46S	probably benign	Het
Tbr1	C	T	2: 61,635,583 (GRCm39)	Q178*	probably null	Het
Vax2	T	C	6: 83,714,885 (GRCm39)	S267P	probably damaging	Het
Vmn1r47	T	A	6: 89,999,298 (GRCm39)	Y143*	probably null	Het
Vmn2r28	A	G	7: 5,491,123 (GRCm39)	S375P	possibly damaging	Het
Vmn2r44	A	T	7: 8,380,814 (GRCm39)	Y360N	possibly damaging	Het
Zc3h6	G	A	2: 128,835,146 (GRCm39)	S94N	possibly damaging	Het

Other mutations in Svopl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00742:Svopl	APN	6	38,007,952 (GRCm39)	critical splice donor site	probably null
IGL01531:Svopl	APN	6	38,003,876 (GRCm39)	splice site	probably benign
IGL02554:Svopl	APN	6	37,993,978 (GRCm39)	missense	probably damaging	0.99
IGL03249:Svopl	APN	6	37,993,988 (GRCm39)	missense	probably benign	0.05
PIT4434001:Svopl	UTSW	6	37,991,801 (GRCm39)	missense	possibly damaging	0.85
R0285:Svopl	UTSW	6	37,961,457 (GRCm39)	missense	probably benign	0.02
R0423:Svopl	UTSW	6	38,013,642 (GRCm39)	splice site	probably benign
R0692:Svopl	UTSW	6	37,994,131 (GRCm39)	missense	probably damaging	1.00
R0960:Svopl	UTSW	6	37,993,992 (GRCm39)	nonsense	probably null
R1163:Svopl	UTSW	6	38,006,635 (GRCm39)	missense	possibly damaging	0.89
R1526:Svopl	UTSW	6	38,006,570 (GRCm39)	missense	probably benign	0.03
R2295:Svopl	UTSW	6	37,996,668 (GRCm39)	missense	possibly damaging	0.52
R2302:Svopl	UTSW	6	38,018,101 (GRCm39)	splice site	probably benign
R5933:Svopl	UTSW	6	37,993,949 (GRCm39)	splice site	probably benign
R6367:Svopl	UTSW	6	37,996,614 (GRCm39)	missense	possibly damaging	0.88
R6595:Svopl	UTSW	6	38,018,002 (GRCm39)	splice site	probably null
R6903:Svopl	UTSW	6	37,998,543 (GRCm39)	missense	probably benign	0.00
R7980:Svopl	UTSW	6	37,991,744 (GRCm39)	missense	probably damaging	0.98
R8167:Svopl	UTSW	6	37,993,979 (GRCm39)	missense	probably damaging	1.00
R8218:Svopl	UTSW	6	37,991,741 (GRCm39)	missense	probably benign
R9046:Svopl	UTSW	6	37,998,531 (GRCm39)	missense	probably benign	0.02
Z1177:Svopl	UTSW	6	38,006,646 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16