Incidental Mutation 'IGL02162:Zfp267'
| ID |
282505 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp267
|
| Ensembl Gene |
ENSMUSG00000033883 |
| Gene Name |
zinc finger protein 267 |
| Synonyms |
D3Ertd254e |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.128)
|
| Stock # |
IGL02162
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
36205233-36224491 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 36218210 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 78
(F78L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142829
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165956]
[ENSMUST00000197653]
[ENSMUST00000205077]
|
| AlphaFold |
A0A0G2JEM5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165956
AA Change: F77L
PolyPhen 2
Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000131779
Gene: ENSMUSG00000033883
AA Change: F77L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
63 |
2.91e-34 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.08e-1 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
451 |
473 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
479 |
501 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
507 |
529 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
535 |
557 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
563 |
585 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
591 |
613 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
619 |
641 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
647 |
669 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
675 |
697 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
703 |
725 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
731 |
753 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
759 |
779 |
3.85e1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197653
AA Change: F78L
PolyPhen 2
Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000142829
Gene: ENSMUSG00000033883
AA Change: F78L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
1.2e-36 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
4.4e-4 |
SMART |
|
ZnF_C2H2
|
396 |
418 |
6.7e-5 |
SMART |
|
ZnF_C2H2
|
424 |
446 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
452 |
474 |
2.5e-5 |
SMART |
|
ZnF_C2H2
|
480 |
502 |
7.9e-6 |
SMART |
|
ZnF_C2H2
|
508 |
530 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
536 |
558 |
7.7e-7 |
SMART |
|
ZnF_C2H2
|
564 |
586 |
8e-6 |
SMART |
|
ZnF_C2H2
|
592 |
614 |
8.9e-5 |
SMART |
|
ZnF_C2H2
|
620 |
642 |
6.6e-7 |
SMART |
|
ZnF_C2H2
|
648 |
670 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
676 |
698 |
7.1e-6 |
SMART |
|
ZnF_C2H2
|
704 |
726 |
1.1e-6 |
SMART |
|
ZnF_C2H2
|
732 |
754 |
4.8e-6 |
SMART |
|
ZnF_C2H2
|
760 |
780 |
1.6e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205077
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ang5 |
T |
C |
14: 44,199,966 (GRCm39) |
L10S |
probably damaging |
Het |
| Cdk5rap1 |
T |
C |
2: 154,177,489 (GRCm39) |
T577A |
probably damaging |
Het |
| Clca3a1 |
G |
T |
3: 144,460,564 (GRCm39) |
P297T |
probably damaging |
Het |
| Col9a2 |
A |
T |
4: 120,911,531 (GRCm39) |
|
probably benign |
Het |
| Ctss |
A |
G |
3: 95,454,132 (GRCm39) |
K227R |
probably benign |
Het |
| Dmxl1 |
G |
A |
18: 50,094,230 (GRCm39) |
R2902Q |
probably benign |
Het |
| Dnah10 |
G |
T |
5: 124,881,810 (GRCm39) |
A2862S |
probably damaging |
Het |
| Elp1 |
A |
G |
4: 56,796,502 (GRCm39) |
|
probably null |
Het |
| Fbxw5 |
C |
A |
2: 25,393,283 (GRCm39) |
Q16K |
probably damaging |
Het |
| Fcgbp |
G |
A |
7: 27,774,660 (GRCm39) |
C78Y |
probably damaging |
Het |
| Gm20547 |
T |
A |
17: 35,076,003 (GRCm39) |
Y688F |
possibly damaging |
Het |
| Gpaa1 |
T |
C |
15: 76,216,353 (GRCm39) |
|
probably benign |
Het |
| Grik2 |
T |
C |
10: 49,298,671 (GRCm39) |
H63R |
possibly damaging |
Het |
| Ikbke |
A |
G |
1: 131,201,452 (GRCm39) |
S132P |
possibly damaging |
Het |
| Kirrel2 |
A |
G |
7: 30,153,089 (GRCm39) |
I340T |
probably benign |
Het |
| Lipo5 |
A |
T |
19: 33,446,163 (GRCm39) |
|
probably benign |
Het |
| Nfkbie |
T |
G |
17: 45,867,242 (GRCm39) |
|
probably null |
Het |
| Ntng1 |
G |
T |
3: 109,842,311 (GRCm39) |
S154* |
probably null |
Het |
| Or6c208 |
C |
T |
10: 129,223,973 (GRCm39) |
P157L |
probably benign |
Het |
| Or8b12b |
A |
G |
9: 37,684,227 (GRCm39) |
I91V |
probably benign |
Het |
| Pbld2 |
T |
C |
10: 62,907,179 (GRCm39) |
|
probably benign |
Het |
| Phaf1 |
C |
T |
8: 105,966,605 (GRCm39) |
|
probably benign |
Het |
| Plec |
C |
T |
15: 76,064,360 (GRCm39) |
M1971I |
probably benign |
Het |
| Ppp1r3a |
A |
T |
6: 14,717,714 (GRCm39) |
F1067I |
probably damaging |
Het |
| Qpctl |
A |
G |
7: 18,878,606 (GRCm39) |
F290L |
possibly damaging |
Het |
| Sorcs3 |
A |
T |
19: 48,523,970 (GRCm39) |
Y288F |
probably damaging |
Het |
| St8sia3 |
A |
G |
18: 64,398,651 (GRCm39) |
N37D |
probably benign |
Het |
| Vmn2r109 |
T |
C |
17: 20,774,422 (GRCm39) |
D311G |
probably benign |
Het |
| Zbtb44 |
A |
G |
9: 30,964,688 (GRCm39) |
I33V |
probably benign |
Het |
| Zfp541 |
C |
A |
7: 15,813,393 (GRCm39) |
T682K |
possibly damaging |
Het |
|
| Other mutations in Zfp267 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01524:Zfp267
|
APN |
3 |
36,218,729 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02089:Zfp267
|
APN |
3 |
36,218,877 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0243:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R0512:Zfp267
|
UTSW |
3 |
36,220,262 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0722:Zfp267
|
UTSW |
3 |
36,219,218 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0762:Zfp267
|
UTSW |
3 |
36,220,016 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0792:Zfp267
|
UTSW |
3 |
36,218,711 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0894:Zfp267
|
UTSW |
3 |
36,218,935 (GRCm39) |
nonsense |
probably null |
|
|
R1731:Zfp267
|
UTSW |
3 |
36,218,620 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2098:Zfp267
|
UTSW |
3 |
36,220,289 (GRCm39) |
missense |
probably benign |
|
|
R2099:Zfp267
|
UTSW |
3 |
36,218,361 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3709:Zfp267
|
UTSW |
3 |
36,213,725 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3808:Zfp267
|
UTSW |
3 |
36,219,792 (GRCm39) |
splice site |
probably null |
|
|
R4035:Zfp267
|
UTSW |
3 |
36,218,989 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4288:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4289:Zfp267
|
UTSW |
3 |
36,213,747 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4959:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4973:Zfp267
|
UTSW |
3 |
36,218,285 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5102:Zfp267
|
UTSW |
3 |
36,216,814 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5462:Zfp267
|
UTSW |
3 |
36,219,969 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5548:Zfp267
|
UTSW |
3 |
36,219,640 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5782:Zfp267
|
UTSW |
3 |
36,219,128 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6153:Zfp267
|
UTSW |
3 |
36,219,303 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6225:Zfp267
|
UTSW |
3 |
36,220,352 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6602:Zfp267
|
UTSW |
3 |
36,219,004 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6785:Zfp267
|
UTSW |
3 |
36,219,601 (GRCm39) |
nonsense |
probably null |
|
|
R7513:Zfp267
|
UTSW |
3 |
36,218,792 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7846:Zfp267
|
UTSW |
3 |
36,219,738 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8120:Zfp267
|
UTSW |
3 |
36,218,640 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8265:Zfp267
|
UTSW |
3 |
36,213,677 (GRCm39) |
start gained |
probably benign |
|
|
R8415:Zfp267
|
UTSW |
3 |
36,219,182 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8826:Zfp267
|
UTSW |
3 |
36,218,255 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9026:Zfp267
|
UTSW |
3 |
36,219,066 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R9159:Zfp267
|
UTSW |
3 |
36,219,902 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9786:Zfp267
|
UTSW |
3 |
36,219,853 (GRCm39) |
nonsense |
probably null |
|
|
X0021:Zfp267
|
UTSW |
3 |
36,218,340 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
| Posted On |
2015-04-16 |
Incidental Mutation