Incidental Mutation 'IGL02164:Gucy2g'
| ID |
282559 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gucy2g
|
| Ensembl Gene |
ENSMUSG00000055523 |
| Gene Name |
guanylate cyclase 2g |
| Synonyms |
2410077I05Rik, GC-G |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02164
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
55186531-55229668 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 55226455 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Asparagine
at position 154
(H154N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000068253
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069183]
|
| AlphaFold |
Q6TL19 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069183
AA Change: H154N
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000068253
Gene: ENSMUSG00000055523
AA Change: H154N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
38 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
65 |
416 |
5.2e-36 |
PFAM |
|
low complexity region
|
471 |
487 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
574 |
826 |
2e-26 |
PFAM |
|
Pfam:Pkinase_Tyr
|
577 |
826 |
6e-35 |
PFAM |
|
CYCc
|
865 |
1059 |
6.42e-96 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5730480H06Rik |
T |
A |
5: 48,537,524 (GRCm39) |
V187E |
probably benign |
Het |
| Abcc12 |
T |
A |
8: 87,254,033 (GRCm39) |
D917V |
probably damaging |
Het |
| Abhd15 |
A |
T |
11: 77,406,840 (GRCm39) |
E272D |
probably benign |
Het |
| Adat3 |
T |
A |
10: 80,442,461 (GRCm39) |
S100T |
probably benign |
Het |
| Adgrg6 |
T |
C |
10: 14,399,299 (GRCm39) |
|
probably benign |
Het |
| Alpl |
C |
T |
4: 137,481,290 (GRCm39) |
V121M |
probably damaging |
Het |
| Ano1 |
A |
T |
7: 144,190,918 (GRCm39) |
Y388N |
possibly damaging |
Het |
| Arrdc4 |
C |
T |
7: 68,389,285 (GRCm39) |
|
probably benign |
Het |
| Asxl2 |
A |
G |
12: 3,552,079 (GRCm39) |
M1274V |
probably benign |
Het |
| Bmt2 |
G |
T |
6: 13,628,878 (GRCm39) |
N268K |
possibly damaging |
Het |
| Bpifb2 |
C |
A |
2: 153,725,482 (GRCm39) |
L176M |
probably damaging |
Het |
| Brd8 |
C |
T |
18: 34,735,780 (GRCm39) |
S899N |
probably damaging |
Het |
| Cd14 |
T |
C |
18: 36,858,838 (GRCm39) |
R206G |
possibly damaging |
Het |
| Cfap65 |
G |
T |
1: 74,967,304 (GRCm39) |
T215K |
possibly damaging |
Het |
| Chd9 |
T |
C |
8: 91,659,849 (GRCm39) |
S270P |
possibly damaging |
Het |
| Cidea |
C |
T |
18: 67,499,581 (GRCm39) |
S156L |
probably damaging |
Het |
| Col5a3 |
A |
G |
9: 20,703,939 (GRCm39) |
|
probably null |
Het |
| Cspg5 |
T |
C |
9: 110,080,104 (GRCm39) |
V424A |
probably damaging |
Het |
| Ctc1 |
A |
G |
11: 68,916,922 (GRCm39) |
H272R |
probably damaging |
Het |
| D5Ertd579e |
A |
T |
5: 36,772,303 (GRCm39) |
S697R |
probably damaging |
Het |
| Dennd3 |
T |
C |
15: 73,416,297 (GRCm39) |
S516P |
probably benign |
Het |
| Dipk2b |
T |
A |
X: 18,285,192 (GRCm39) |
R421* |
probably null |
Het |
| Dlgap4 |
G |
A |
2: 156,553,059 (GRCm39) |
R509H |
probably damaging |
Het |
| Dus3l |
T |
C |
17: 57,074,943 (GRCm39) |
|
probably benign |
Het |
| Dync1h1 |
G |
T |
12: 110,628,993 (GRCm39) |
W4183C |
probably damaging |
Het |
| Eif2s3x |
A |
T |
X: 93,248,678 (GRCm39) |
M152K |
possibly damaging |
Het |
| Epb41l1 |
C |
T |
2: 156,336,869 (GRCm39) |
|
probably benign |
Het |
| Ephx2 |
A |
G |
14: 66,341,169 (GRCm39) |
|
probably benign |
Het |
| Fabp12 |
T |
A |
3: 10,311,075 (GRCm39) |
Y129F |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 15,942,720 (GRCm39) |
|
probably benign |
Het |
| Fat4 |
T |
C |
3: 39,050,354 (GRCm39) |
|
probably null |
Het |
| Gnb1 |
T |
A |
4: 155,641,631 (GRCm39) |
|
probably null |
Het |
| Gpr107 |
C |
A |
2: 31,068,298 (GRCm39) |
Y253* |
probably null |
Het |
| Grb10 |
C |
T |
11: 11,893,962 (GRCm39) |
E320K |
probably damaging |
Het |
| H2bl1 |
T |
C |
13: 99,120,715 (GRCm39) |
K104E |
probably damaging |
Het |
| Hemk1 |
T |
A |
9: 107,208,735 (GRCm39) |
H154L |
probably benign |
Het |
| Hk2 |
A |
T |
6: 82,720,920 (GRCm39) |
|
probably null |
Het |
| Htr5a |
A |
G |
5: 28,047,463 (GRCm39) |
N6S |
probably damaging |
Het |
| Htra3 |
T |
C |
5: 35,810,410 (GRCm39) |
D424G |
probably benign |
Het |
| Ift52 |
A |
G |
2: 162,867,384 (GRCm39) |
|
probably null |
Het |
| Igdcc4 |
A |
G |
9: 65,032,064 (GRCm39) |
|
probably benign |
Het |
| Itpr1 |
A |
G |
6: 108,366,444 (GRCm39) |
K124E |
probably benign |
Het |
| Kcnc2 |
T |
A |
10: 112,291,590 (GRCm39) |
N259K |
possibly damaging |
Het |
| Kics2 |
A |
G |
10: 121,586,675 (GRCm39) |
Y194C |
probably damaging |
Het |
| Lmod2 |
A |
T |
6: 24,603,909 (GRCm39) |
I295F |
possibly damaging |
Het |
| Lrp1 |
T |
C |
10: 127,399,536 (GRCm39) |
E2324G |
probably benign |
Het |
| Lss |
T |
C |
10: 76,372,094 (GRCm39) |
S150P |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,374,065 (GRCm39) |
N1515S |
probably benign |
Het |
| Mapk11 |
T |
C |
15: 89,029,651 (GRCm39) |
|
probably null |
Het |
| Mc3r |
T |
A |
2: 172,091,314 (GRCm39) |
F179I |
probably damaging |
Het |
| Mtmr9 |
T |
A |
14: 63,767,737 (GRCm39) |
N291Y |
probably damaging |
Het |
| Myo1h |
T |
C |
5: 114,472,157 (GRCm39) |
F396L |
probably damaging |
Het |
| Nek2 |
A |
G |
1: 191,559,416 (GRCm39) |
K307R |
probably benign |
Het |
| Or12d2 |
C |
A |
17: 37,624,578 (GRCm39) |
M232I |
probably benign |
Het |
| Osmr |
G |
A |
15: 6,871,529 (GRCm39) |
T296I |
probably damaging |
Het |
| Pcdhb11 |
T |
G |
18: 37,556,412 (GRCm39) |
S581A |
probably benign |
Het |
| Pfkp |
C |
T |
13: 6,647,951 (GRCm39) |
V542M |
probably damaging |
Het |
| Pmpca |
C |
T |
2: 26,285,581 (GRCm39) |
S519L |
probably benign |
Het |
| Ptgds |
A |
T |
2: 25,359,124 (GRCm39) |
Y44N |
probably damaging |
Het |
| Raly |
T |
A |
2: 154,701,849 (GRCm39) |
Y116* |
probably null |
Het |
| Rock2 |
A |
G |
12: 17,015,530 (GRCm39) |
D809G |
probably damaging |
Het |
| Sgsm2 |
T |
G |
11: 74,756,242 (GRCm39) |
N369T |
possibly damaging |
Het |
| Slc6a15 |
A |
G |
10: 103,254,083 (GRCm39) |
D673G |
probably benign |
Het |
| Spire2 |
A |
T |
8: 124,059,703 (GRCm39) |
D67V |
probably damaging |
Het |
| St7l |
T |
C |
3: 104,829,597 (GRCm39) |
|
probably null |
Het |
| Stau2 |
A |
G |
1: 16,416,052 (GRCm39) |
L469P |
probably damaging |
Het |
| Tefm |
A |
G |
11: 80,030,915 (GRCm39) |
L107S |
probably damaging |
Het |
| Ticam1 |
A |
T |
17: 56,577,019 (GRCm39) |
V692D |
unknown |
Het |
| Tipin |
T |
A |
9: 64,201,631 (GRCm39) |
D143E |
probably damaging |
Het |
| Tmem132c |
C |
A |
5: 127,613,441 (GRCm39) |
T448K |
probably damaging |
Het |
| Trav8-1 |
A |
T |
14: 53,707,213 (GRCm39) |
M1L |
unknown |
Het |
| Ttn |
C |
A |
2: 76,569,141 (GRCm39) |
V27251F |
probably damaging |
Het |
| Uvrag |
A |
T |
7: 98,653,896 (GRCm39) |
C31* |
probably null |
Het |
| Zap70 |
T |
C |
1: 36,810,267 (GRCm39) |
Y126H |
probably damaging |
Het |
| Zfp644 |
A |
G |
5: 106,785,965 (GRCm39) |
V194A |
probably benign |
Het |
| Zfp663 |
C |
T |
2: 165,200,968 (GRCm39) |
W22* |
probably null |
Het |
|
| Other mutations in Gucy2g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00801:Gucy2g
|
APN |
19 |
55,221,535 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01954:Gucy2g
|
APN |
19 |
55,187,123 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01969:Gucy2g
|
APN |
19 |
55,215,870 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02534:Gucy2g
|
APN |
19 |
55,229,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02667:Gucy2g
|
APN |
19 |
55,194,609 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02755:Gucy2g
|
APN |
19 |
55,198,786 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03187:Gucy2g
|
APN |
19 |
55,219,484 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL03354:Gucy2g
|
APN |
19 |
55,221,512 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
PIT4366001:Gucy2g
|
UTSW |
19 |
55,226,214 (GRCm39) |
missense |
probably null |
0.51 |
|
R0040:Gucy2g
|
UTSW |
19 |
55,205,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0126:Gucy2g
|
UTSW |
19 |
55,229,598 (GRCm39) |
missense |
probably benign |
|
|
R0318:Gucy2g
|
UTSW |
19 |
55,226,230 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0576:Gucy2g
|
UTSW |
19 |
55,187,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0604:Gucy2g
|
UTSW |
19 |
55,191,519 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0962:Gucy2g
|
UTSW |
19 |
55,198,716 (GRCm39) |
nonsense |
probably null |
|
|
R1348:Gucy2g
|
UTSW |
19 |
55,211,338 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1458:Gucy2g
|
UTSW |
19 |
55,203,468 (GRCm39) |
splice site |
probably benign |
|
|
R1693:Gucy2g
|
UTSW |
19 |
55,211,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1795:Gucy2g
|
UTSW |
19 |
55,187,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Gucy2g
|
UTSW |
19 |
55,198,741 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1830:Gucy2g
|
UTSW |
19 |
55,211,362 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1902:Gucy2g
|
UTSW |
19 |
55,198,669 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1927:Gucy2g
|
UTSW |
19 |
55,226,191 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1969:Gucy2g
|
UTSW |
19 |
55,221,485 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1969:Gucy2g
|
UTSW |
19 |
55,211,328 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2071:Gucy2g
|
UTSW |
19 |
55,210,772 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R2842:Gucy2g
|
UTSW |
19 |
55,229,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2971:Gucy2g
|
UTSW |
19 |
55,198,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4202:Gucy2g
|
UTSW |
19 |
55,218,201 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R4405:Gucy2g
|
UTSW |
19 |
55,226,269 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4407:Gucy2g
|
UTSW |
19 |
55,226,269 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4614:Gucy2g
|
UTSW |
19 |
55,190,579 (GRCm39) |
nonsense |
probably null |
|
|
R4671:Gucy2g
|
UTSW |
19 |
55,226,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4684:Gucy2g
|
UTSW |
19 |
55,194,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4837:Gucy2g
|
UTSW |
19 |
55,214,485 (GRCm39) |
missense |
probably benign |
|
|
R4969:Gucy2g
|
UTSW |
19 |
55,214,445 (GRCm39) |
missense |
probably benign |
|
|
R5050:Gucy2g
|
UTSW |
19 |
55,229,367 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5059:Gucy2g
|
UTSW |
19 |
55,214,503 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5070:Gucy2g
|
UTSW |
19 |
55,218,219 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5288:Gucy2g
|
UTSW |
19 |
55,203,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5384:Gucy2g
|
UTSW |
19 |
55,203,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5386:Gucy2g
|
UTSW |
19 |
55,203,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5497:Gucy2g
|
UTSW |
19 |
55,187,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5531:Gucy2g
|
UTSW |
19 |
55,229,572 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5536:Gucy2g
|
UTSW |
19 |
55,226,359 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5679:Gucy2g
|
UTSW |
19 |
55,219,511 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5715:Gucy2g
|
UTSW |
19 |
55,221,587 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5941:Gucy2g
|
UTSW |
19 |
55,203,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6250:Gucy2g
|
UTSW |
19 |
55,205,856 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6288:Gucy2g
|
UTSW |
19 |
55,215,945 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6378:Gucy2g
|
UTSW |
19 |
55,229,377 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6605:Gucy2g
|
UTSW |
19 |
55,229,460 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7020:Gucy2g
|
UTSW |
19 |
55,221,482 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7064:Gucy2g
|
UTSW |
19 |
55,198,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7078:Gucy2g
|
UTSW |
19 |
55,229,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7402:Gucy2g
|
UTSW |
19 |
55,194,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Gucy2g
|
UTSW |
19 |
55,191,586 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7561:Gucy2g
|
UTSW |
19 |
55,194,772 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7583:Gucy2g
|
UTSW |
19 |
55,224,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7804:Gucy2g
|
UTSW |
19 |
55,216,584 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7880:Gucy2g
|
UTSW |
19 |
55,194,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8442:Gucy2g
|
UTSW |
19 |
55,205,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8559:Gucy2g
|
UTSW |
19 |
55,198,786 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8970:Gucy2g
|
UTSW |
19 |
55,191,478 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8972:Gucy2g
|
UTSW |
19 |
55,226,406 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9085:Gucy2g
|
UTSW |
19 |
55,221,597 (GRCm39) |
nonsense |
probably null |
|
|
R9390:Gucy2g
|
UTSW |
19 |
55,190,607 (GRCm39) |
missense |
probably null |
1.00 |
|
R9462:Gucy2g
|
UTSW |
19 |
55,221,469 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9502:Gucy2g
|
UTSW |
19 |
55,198,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9610:Gucy2g
|
UTSW |
19 |
55,194,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9611:Gucy2g
|
UTSW |
19 |
55,194,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9644:Gucy2g
|
UTSW |
19 |
55,219,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1177:Gucy2g
|
UTSW |
19 |
55,198,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation