Incidental Mutation 'IGL00976:Olfr952'
ID 28259
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr952
Ensembl Gene ENSMUSG00000058856
Gene Name olfactory receptor 952
Synonyms MOR171-21, GA_x6K02T2PVTD-33124064-33123120
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL00976
Quality Score
Status
Chromosome 9
Chromosomal Location 39426093-39427148 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39426657 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 138 (Y138F)
Ref Sequence ENSEMBL: ENSMUSP00000073558 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073895]
AlphaFold Q8VFD7
Predicted Effect probably benign
Transcript: ENSMUST00000073895
AA Change: Y138F

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000073558
Gene: ENSMUSG00000058856
AA Change: Y138F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8.5e-42 PFAM
Pfam:7tm_1 41 294 3.2e-18 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519F16Rik A G X: 103,183,262 probably benign Het
Aldob C A 4: 49,541,220 V151L probably damaging Het
Cacna1i G A 15: 80,355,645 M298I probably benign Het
Capn3 A G 2: 120,491,901 N414S possibly damaging Het
Ccdc186 G A 19: 56,797,500 T701M probably damaging Het
Ccdc190 A T 1: 169,933,740 H137L probably benign Het
Clhc1 G A 11: 29,561,389 D278N probably benign Het
Cntnap3 T C 13: 64,794,352 Y188C probably damaging Het
Dnah1 A C 14: 31,278,138 V2466G probably damaging Het
Dnah8 A G 17: 30,851,710 T4457A probably damaging Het
Gm13078 T A 4: 143,727,015 M231K probably damaging Het
Hectd4 A G 5: 121,349,106 Q3388R probably benign Het
Hecw1 T A 13: 14,318,972 D316V probably damaging Het
Il1rap T C 16: 26,698,839 V263A probably benign Het
Il6 G A 5: 30,014,841 G72S probably benign Het
Katnal2 T C 18: 77,017,493 Y86C probably damaging Het
Kdm7a G T 6: 39,144,398 S874R possibly damaging Het
Mybpc2 T C 7: 44,522,317 probably null Het
Nphs1 T G 7: 30,460,685 S130A possibly damaging Het
Ntrk3 C T 7: 78,450,953 V444I probably benign Het
Numbl T C 7: 27,268,810 V144A possibly damaging Het
P2rx1 T C 11: 73,013,000 probably null Het
Pcdhb3 G A 18: 37,302,948 V656I probably benign Het
Pole A G 5: 110,323,572 Y1394C probably benign Het
Rbm47 A G 5: 66,026,738 V174A possibly damaging Het
Rhox4f T C X: 37,604,395 probably benign Het
Serpina12 T C 12: 104,032,528 Y317C probably damaging Het
Slc12a5 T A 2: 164,979,304 I236N probably damaging Het
Slc4a4 G A 5: 88,954,798 G32R probably damaging Het
Slco1a4 T C 6: 141,807,182 probably null Het
Sorcs3 A T 19: 48,767,103 N894I probably damaging Het
Stk38l A G 6: 146,775,402 E393G probably benign Het
Synpo A G 18: 60,603,419 I485T possibly damaging Het
Tenm3 T A 8: 48,256,841 M1687L probably benign Het
Ttc39c T C 18: 12,684,895 probably benign Het
Unc13d T C 11: 116,070,467 E378G probably damaging Het
Vmn2r118 T A 17: 55,593,204 N567Y probably damaging Het
Other mutations in Olfr952
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01368:Olfr952 APN 9 39426180 missense probably damaging 1.00
IGL01866:Olfr952 APN 9 39426729 missense probably damaging 0.99
IGL01939:Olfr952 APN 9 39426338 missense probably damaging 1.00
IGL03048:Olfr952 UTSW 9 39426769 missense probably benign 0.00
R0069:Olfr952 UTSW 9 39426892 missense probably damaging 0.98
R1460:Olfr952 UTSW 9 39426207 missense probably benign 0.43
R1478:Olfr952 UTSW 9 39426592 missense possibly damaging 0.91
R1737:Olfr952 UTSW 9 39426958 missense probably damaging 0.99
R2112:Olfr952 UTSW 9 39426670 missense probably benign 0.26
R2169:Olfr952 UTSW 9 39426358 missense possibly damaging 0.95
R2225:Olfr952 UTSW 9 39426619 missense probably benign 0.00
R3731:Olfr952 UTSW 9 39427069 start codon destroyed probably benign 0.23
R3777:Olfr952 UTSW 9 39426605 missense possibly damaging 0.75
R3802:Olfr952 UTSW 9 39426286 missense probably damaging 1.00
R4600:Olfr952 UTSW 9 39426435 missense probably benign 0.27
R4887:Olfr952 UTSW 9 39426235 missense possibly damaging 0.80
R5215:Olfr952 UTSW 9 39426623 nonsense probably null
R5813:Olfr952 UTSW 9 39426736 missense probably damaging 1.00
R6140:Olfr952 UTSW 9 39426247 missense possibly damaging 0.91
R6180:Olfr952 UTSW 9 39426712 missense probably damaging 1.00
R6383:Olfr952 UTSW 9 39426234 missense probably damaging 1.00
R6416:Olfr952 UTSW 9 39426891 missense probably damaging 0.98
R6808:Olfr952 UTSW 9 39426540 missense probably damaging 0.99
R7099:Olfr952 UTSW 9 39426303 missense probably benign 0.01
R7826:Olfr952 UTSW 9 39426127 makesense probably null
R8309:Olfr952 UTSW 9 39426670 missense probably benign 0.40
R8870:Olfr952 UTSW 9 39426252 missense probably damaging 0.97
R8879:Olfr952 UTSW 9 39426219 missense possibly damaging 0.86
R9084:Olfr952 UTSW 9 39426225 missense probably damaging 1.00
R9209:Olfr952 UTSW 9 39426339 missense probably damaging 0.99
R9435:Olfr952 UTSW 9 39426210 missense probably benign
R9583:Olfr952 UTSW 9 39426555 missense possibly damaging 0.91
Posted On 2013-04-17