Incidental Mutation 'IGL02164:Arrdc4'
ID282623
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arrdc4
Ensembl Gene ENSMUSG00000042659
Gene Namearrestin domain containing 4
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.182) question?
Stock #IGL02164
Quality Score
Status
Chromosome7
Chromosomal Location68736995-68749241 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) C to T at 68739537 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112962 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048068] [ENSMUST00000118110]
Predicted Effect probably benign
Transcript: ENSMUST00000048068
SMART Domains Protein: ENSMUSP00000044578
Gene: ENSMUSG00000042659

DomainStartEndE-ValueType
Pfam:Arrestin_N 19 166 6.2e-35 PFAM
Arrestin_C 188 315 8.24e-30 SMART
low complexity region 336 348 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000118110
SMART Domains Protein: ENSMUSP00000112962
Gene: ENSMUSG00000042659

DomainStartEndE-ValueType
Pfam:Arrestin_N 17 166 6.6e-35 PFAM
Arrestin_C 188 296 6.46e-14 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele show a marked reduction in the amount of extracellular vesicles (EVs) released from mouse gut explants. Mutant mouse embryonic fibroblasts exhibit reduced EV release. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700024P04Rik T C 13: 98,984,207 K104E probably damaging Het
4930578C19Rik T A X: 18,418,953 R421* probably null Het
5730480H06Rik T A 5: 48,380,182 V187E probably benign Het
Abcc12 T A 8: 86,527,404 D917V probably damaging Het
Abhd15 A T 11: 77,516,014 E272D probably benign Het
Adat3 T A 10: 80,606,627 S100T probably benign Het
Adgrg6 T C 10: 14,523,555 probably benign Het
Alpl C T 4: 137,753,979 V121M probably damaging Het
Ano1 A T 7: 144,637,181 Y388N possibly damaging Het
Asxl2 A G 12: 3,502,079 M1274V probably benign Het
BC048403 A G 10: 121,750,770 Y194C probably damaging Het
Bmt2 G T 6: 13,628,879 N268K possibly damaging Het
Bpifb2 C A 2: 153,883,562 L176M probably damaging Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Cd14 T C 18: 36,725,785 R206G possibly damaging Het
Cfap65 G T 1: 74,928,145 T215K possibly damaging Het
Chd9 T C 8: 90,933,221 S270P possibly damaging Het
Cidea C T 18: 67,366,511 S156L probably damaging Het
Col5a3 A G 9: 20,792,643 probably null Het
Cspg5 T C 9: 110,251,036 V424A probably damaging Het
Ctc1 A G 11: 69,026,096 H272R probably damaging Het
D5Ertd579e A T 5: 36,614,959 S697R probably damaging Het
Dennd3 T C 15: 73,544,448 S516P probably benign Het
Dlgap4 G A 2: 156,711,139 R509H probably damaging Het
Dus3l T C 17: 56,767,943 probably benign Het
Dync1h1 G T 12: 110,662,559 W4183C probably damaging Het
Eif2s3x A T X: 94,205,072 M152K possibly damaging Het
Epb41l1 C T 2: 156,494,949 probably benign Het
Ephx2 A G 14: 66,103,720 probably benign Het
Fabp12 T A 3: 10,246,015 Y129F probably damaging Het
Fat3 A G 9: 16,031,424 probably benign Het
Fat4 T C 3: 38,996,205 probably null Het
Gnb1 T A 4: 155,557,174 probably null Het
Gpr107 C A 2: 31,178,286 Y253* probably null Het
Grb10 C T 11: 11,943,962 E320K probably damaging Het
Gucy2g G T 19: 55,238,023 H154N probably benign Het
Hemk1 T A 9: 107,331,536 H154L probably benign Het
Hk2 A T 6: 82,743,939 probably null Het
Htr5a A G 5: 27,842,465 N6S probably damaging Het
Htra3 T C 5: 35,653,066 D424G probably benign Het
Ift52 A G 2: 163,025,464 probably null Het
Igdcc4 A G 9: 65,124,782 probably benign Het
Itpr1 A G 6: 108,389,483 K124E probably benign Het
Kcnc2 T A 10: 112,455,685 N259K possibly damaging Het
Lmod2 A T 6: 24,603,910 I295F possibly damaging Het
Lrp1 T C 10: 127,563,667 E2324G probably benign Het
Lss T C 10: 76,536,260 S150P probably damaging Het
Macf1 T C 4: 123,480,272 N1515S probably benign Het
Mapk11 T C 15: 89,145,448 probably null Het
Mc3r T A 2: 172,249,394 F179I probably damaging Het
Mtmr9 T A 14: 63,530,288 N291Y probably damaging Het
Myo1h T C 5: 114,334,096 F396L probably damaging Het
Nek2 A G 1: 191,827,304 K307R probably benign Het
Olfr102 C A 17: 37,313,687 M232I probably benign Het
Osmr G A 15: 6,842,048 T296I probably damaging Het
Pcdhb11 T G 18: 37,423,359 S581A probably benign Het
Pfkp C T 13: 6,597,915 V542M probably damaging Het
Pmpca C T 2: 26,395,569 S519L probably benign Het
Ptgds A T 2: 25,469,112 Y44N probably damaging Het
Raly T A 2: 154,859,929 Y116* probably null Het
Rock2 A G 12: 16,965,529 D809G probably damaging Het
Sgsm2 T G 11: 74,865,416 N369T possibly damaging Het
Slc6a15 A G 10: 103,418,222 D673G probably benign Het
Spire2 A T 8: 123,332,964 D67V probably damaging Het
St7l T C 3: 104,922,281 probably null Het
Stau2 A G 1: 16,345,828 L469P probably damaging Het
Tefm A G 11: 80,140,089 L107S probably damaging Het
Ticam1 A T 17: 56,270,019 V692D unknown Het
Tipin T A 9: 64,294,349 D143E probably damaging Het
Tmem132c C A 5: 127,536,377 T448K probably damaging Het
Trav8-1 A T 14: 53,469,756 M1L unknown Het
Ttn C A 2: 76,738,797 V27251F probably damaging Het
Uvrag A T 7: 99,004,689 C31* probably null Het
Zap70 T C 1: 36,771,186 Y126H probably damaging Het
Zfp644 A G 5: 106,638,099 V194A probably benign Het
Zfp663 C T 2: 165,359,048 W22* probably null Het
Other mutations in Arrdc4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01637:Arrdc4 APN 7 68744832 nonsense probably null
IGL03009:Arrdc4 APN 7 68739493 missense probably damaging 1.00
R0454:Arrdc4 UTSW 7 68741871 missense probably damaging 1.00
R1146:Arrdc4 UTSW 7 68740008 missense probably damaging 0.99
R1146:Arrdc4 UTSW 7 68740008 missense probably damaging 0.99
R1588:Arrdc4 UTSW 7 68741736 missense possibly damaging 0.95
R1764:Arrdc4 UTSW 7 68741874 missense probably damaging 1.00
R1956:Arrdc4 UTSW 7 68741799 missense probably benign 0.16
R4717:Arrdc4 UTSW 7 68741658 missense probably damaging 0.98
R6321:Arrdc4 UTSW 7 68749045 missense probably benign 0.21
R6784:Arrdc4 UTSW 7 68748846 missense probably benign 0.00
R7329:Arrdc4 UTSW 7 68741027 missense probably damaging 1.00
R7689:Arrdc4 UTSW 7 68741875 missense probably damaging 1.00
R7909:Arrdc4 UTSW 7 68745176 missense probably benign 0.30
R7911:Arrdc4 UTSW 7 68745176 missense probably benign 0.30
R7970:Arrdc4 UTSW 7 68741072 missense probably damaging 1.00
Posted On2015-04-16