Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02165:Zfp566'

282677

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp566

Ensembl Gene

ENSMUSG00000078768

Gene Name

zinc finger protein 566

Synonyms

2700043M03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL02165

Quality Score

Status

Chromosome

Chromosomal Location

29776762-29789935 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 29777255 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 309 (C309S)

Ref Sequence

ENSEMBL: ENSMUSP00000086164 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080834] [ENSMUST00000088785] [ENSMUST00000182746]

AlphaFold

Q8VCI1

Predicted Effect

probably benign
Transcript: ENSMUST00000080834

SMART Domains

Protein: ENSMUSP00000079647
Gene: ENSMUSG00000098022

Domain	Start	End	E-Value	Type
KRAB	6	66	8.68e-33	SMART
ZnF_C2H2	168	190	1.1e-2	SMART
ZnF_C2H2	196	218	1.69e-3	SMART
ZnF_C2H2	224	246	1.79e-2	SMART
ZnF_C2H2	252	274	4.24e-4	SMART
ZnF_C2H2	280	300	5.2e0	SMART
ZnF_C2H2	308	330	7.05e-1	SMART
ZnF_C2H2	336	358	1.2e-3	SMART
ZnF_C2H2	364	386	3.63e-3	SMART
ZnF_C2H2	392	414	4.47e-3	SMART
ZnF_C2H2	420	442	1.79e-2	SMART
ZnF_C2H2	448	470	5.5e-3	SMART
ZnF_C2H2	476	498	5.9e-3	SMART
ZnF_C2H2	504	526	1.92e-2	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000088785
AA Change: C309S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000086164
Gene: ENSMUSG00000078768
AA Change: C309S

Domain	Start	End	E-Value	Type
KRAB	6	67	1.19e-16	SMART
ZnF_C2H2	167	189	4.17e-3	SMART
ZnF_C2H2	195	217	2.05e-2	SMART
ZnF_C2H2	223	245	3.21e-4	SMART
ZnF_C2H2	251	273	2.99e-4	SMART
ZnF_C2H2	279	301	7.9e-4	SMART
ZnF_C2H2	307	329	3.44e-4	SMART
ZnF_C2H2	335	357	1.95e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182248

Predicted Effect

probably benign
Transcript: ENSMUST00000182746

SMART Domains

Protein: ENSMUSP00000138567
Gene: ENSMUSG00000058447

Domain	Start	End	E-Value	Type
KRAB	6	56	1.44e-15	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	T	A	19: 31,904,586 (GRCm39)	M199K	possibly damaging	Het
Abo	C	A	2: 26,733,441 (GRCm39)	V255L	probably damaging	Het
Alas1	A	T	9: 106,115,982 (GRCm39)	M344K	probably damaging	Het
Ap1m1	A	G	8: 73,003,653 (GRCm39)	I118V	probably benign	Het
Ap5m1	A	T	14: 49,316,185 (GRCm39)	I252F	possibly damaging	Het
Arhgef2	G	A	3: 88,553,527 (GRCm39)	R886H	probably damaging	Het
Atp13a4	T	C	16: 29,252,828 (GRCm39)	E706G	probably damaging	Het
Baz2a	C	A	10: 127,955,218 (GRCm39)	A775E	probably benign	Het
C3	A	T	17: 57,532,092 (GRCm39)	F210I	probably benign	Het
Casq1	A	G	1: 172,040,948 (GRCm39)	L280P	probably damaging	Het
Cebpz	A	G	17: 79,229,598 (GRCm39)	F919L	probably damaging	Het
Commd1b	A	T	11: 22,932,072 (GRCm39)		probably benign	Het
Dclre1c	T	A	2: 3,451,418 (GRCm39)		probably benign	Het
Dsc3	T	G	18: 20,116,709 (GRCm39)	M276L	probably benign	Het
Dync2i2	T	C	2: 29,922,172 (GRCm39)	T430A	probably benign	Het
Eftud2	A	G	11: 102,742,573 (GRCm39)		probably benign	Het
Elfn2	T	A	15: 78,557,618 (GRCm39)	T310S	probably benign	Het
Ep300	A	G	15: 81,525,592 (GRCm39)	K1472R	probably benign	Het
Fbxl2	T	C	9: 113,847,099 (GRCm39)	D8G	probably benign	Het
Galnt5	T	A	2: 57,888,877 (GRCm39)	M159K	probably benign	Het
Hars2	T	A	18: 36,916,447 (GRCm39)	M1K	probably null	Het
Hk1	T	C	10: 62,117,667 (GRCm39)	T619A	probably damaging	Het
Ifi44	C	T	3: 151,455,067 (GRCm39)	V53M	probably damaging	Het
Ippk	T	A	13: 49,600,011 (GRCm39)	V339D	possibly damaging	Het
Kcnma1	G	T	14: 23,387,035 (GRCm39)	N875K	possibly damaging	Het
Kdm5a	T	A	6: 120,392,251 (GRCm39)	V991E	probably damaging	Het
Larp6	A	G	9: 60,620,595 (GRCm39)	E36G	probably benign	Het
Lonp2	A	T	8: 87,435,654 (GRCm39)	D210V	probably damaging	Het
Lrrc4c	G	A	2: 97,459,378 (GRCm39)	M1I	probably null	Het
Mmp2	A	G	8: 93,559,847 (GRCm39)	K270R	probably null	Het
Nexmif	C	T	X: 103,128,360 (GRCm39)	V1186I	probably benign	Het
Or11g2	A	G	14: 50,856,468 (GRCm39)	Y263C	probably damaging	Het
Or1x2	A	T	11: 50,918,470 (GRCm39)	I214F	probably benign	Het
Pld2	T	C	11: 70,446,503 (GRCm39)	L763P	probably damaging	Het
Pold1	A	T	7: 44,187,484 (GRCm39)	F644L	probably damaging	Het
Prrc2b	T	C	2: 32,104,652 (GRCm39)	S1377P	probably damaging	Het
Rps18-ps6	T	G	13: 97,896,648 (GRCm39)	K150T	probably benign	Het
Rttn	A	G	18: 89,061,165 (GRCm39)	D1111G	probably benign	Het
Slc27a5	A	G	7: 12,728,875 (GRCm39)	V130A	probably damaging	Het
Slfn8	T	C	11: 82,908,022 (GRCm39)	R174G	probably benign	Het
Slitrk6	G	A	14: 110,989,249 (GRCm39)	P153S	probably benign	Het
Sorcs3	T	C	19: 48,642,511 (GRCm39)	I388T	probably benign	Het
Star	A	T	8: 26,302,843 (GRCm39)	T262S	possibly damaging	Het
Strn	A	T	17: 78,995,049 (GRCm39)	W2R	probably damaging	Het
Tnmd	T	C	X: 132,763,701 (GRCm39)	S172P	probably damaging	Het
Togaram2	A	G	17: 72,004,861 (GRCm39)	K305R	probably benign	Het
Trhde	C	A	10: 114,428,066 (GRCm39)	W410L	probably damaging	Het
Trim5	C	T	7: 103,928,566 (GRCm39)	R125Q	probably damaging	Het
Unc45b	C	T	11: 82,831,007 (GRCm39)		probably benign	Het
Vmn1r80	T	A	7: 11,927,379 (GRCm39)	M163K	probably benign	Het
Wnk4	C	A	11: 101,166,117 (GRCm39)		probably benign	Het
Zfp277	T	A	12: 40,365,802 (GRCm39)	I430F	possibly damaging	Het
Zfp740	T	G	15: 102,121,109 (GRCm39)	F141V	possibly damaging	Het
Zfp87	T	A	13: 67,665,989 (GRCm39)	I158F	probably damaging	Het
Zswim3	C	A	2: 164,663,035 (GRCm39)	A505D	possibly damaging	Het

Other mutations in Zfp566

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00160:Zfp566	APN	7	29,777,936 (GRCm39)	missense	probably benign	0.34
R1442:Zfp566	UTSW	7	29,777,344 (GRCm39)	missense	probably damaging	1.00
R1666:Zfp566	UTSW	7	29,777,901 (GRCm39)	missense	probably benign	0.01
R1855:Zfp566	UTSW	7	29,777,927 (GRCm39)	missense	probably benign	0.00
R2900:Zfp566	UTSW	7	29,777,668 (GRCm39)	missense	possibly damaging	0.89
R4654:Zfp566	UTSW	7	29,777,194 (GRCm39)	missense	probably damaging	1.00
R4752:Zfp566	UTSW	7	29,777,306 (GRCm39)	missense	probably damaging	1.00
R7243:Zfp566	UTSW	7	29,777,701 (GRCm39)	missense	probably benign	0.00
R7625:Zfp566	UTSW	7	29,777,930 (GRCm39)	missense	probably benign	0.02
R8145:Zfp566	UTSW	7	29,777,785 (GRCm39)	missense	probably benign	0.22

Posted On

2015-04-16