Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02165:Zfp277'

282681

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp277

Ensembl Gene

ENSMUSG00000055917

Gene Name

zinc finger protein 277

Synonyms

NIRF4, 2410017E24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL02165

Quality Score

Status

Chromosome

Chromosomal Location

40365045-40495789 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 40365802 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 430 (I430F)

Ref Sequence

ENSEMBL: ENSMUSP00000068032 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069637] [ENSMUST00000069692]

AlphaFold

E9Q6D6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000069637
AA Change: I430F

PolyPhen 2 Score 0.752 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000068032
Gene: ENSMUSG00000055917
AA Change: I430F

Domain	Start	End	E-Value	Type
ZnF_C2H2	59	84	4.27e1	SMART
coiled coil region	143	171	N/A	INTRINSIC
ZnF_C2H2	174	198	3.85e1	SMART
ZnF_C2H2	225	249	2.24e-3	SMART
low complexity region	280	292	N/A	INTRINSIC
ZnF_C2H2	303	326	1.91e1	SMART
ZnF_C2H2	356	382	4.94e0	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000069692
AA Change: I556F

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000064226
Gene: ENSMUSG00000055917
AA Change: I556F

Domain	Start	End	E-Value	Type
ZnF_C2H2	185	210	4.27e1	SMART
coiled coil region	269	297	N/A	INTRINSIC
ZnF_C2H2	300	324	3.85e1	SMART
ZnF_C2H2	351	375	2.24e-3	SMART
low complexity region	406	418	N/A	INTRINSIC
ZnF_C2H2	429	452	1.91e1	SMART
ZnF_C2H2	482	508	4.94e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221604

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit early cellular preplicative senescence in MEFs. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	T	A	19: 31,904,586 (GRCm39)	M199K	possibly damaging	Het
Abo	C	A	2: 26,733,441 (GRCm39)	V255L	probably damaging	Het
Alas1	A	T	9: 106,115,982 (GRCm39)	M344K	probably damaging	Het
Ap1m1	A	G	8: 73,003,653 (GRCm39)	I118V	probably benign	Het
Ap5m1	A	T	14: 49,316,185 (GRCm39)	I252F	possibly damaging	Het
Arhgef2	G	A	3: 88,553,527 (GRCm39)	R886H	probably damaging	Het
Atp13a4	T	C	16: 29,252,828 (GRCm39)	E706G	probably damaging	Het
Baz2a	C	A	10: 127,955,218 (GRCm39)	A775E	probably benign	Het
C3	A	T	17: 57,532,092 (GRCm39)	F210I	probably benign	Het
Casq1	A	G	1: 172,040,948 (GRCm39)	L280P	probably damaging	Het
Cebpz	A	G	17: 79,229,598 (GRCm39)	F919L	probably damaging	Het
Commd1b	A	T	11: 22,932,072 (GRCm39)		probably benign	Het
Dclre1c	T	A	2: 3,451,418 (GRCm39)		probably benign	Het
Dsc3	T	G	18: 20,116,709 (GRCm39)	M276L	probably benign	Het
Dync2i2	T	C	2: 29,922,172 (GRCm39)	T430A	probably benign	Het
Eftud2	A	G	11: 102,742,573 (GRCm39)		probably benign	Het
Elfn2	T	A	15: 78,557,618 (GRCm39)	T310S	probably benign	Het
Ep300	A	G	15: 81,525,592 (GRCm39)	K1472R	probably benign	Het
Fbxl2	T	C	9: 113,847,099 (GRCm39)	D8G	probably benign	Het
Galnt5	T	A	2: 57,888,877 (GRCm39)	M159K	probably benign	Het
Hars2	T	A	18: 36,916,447 (GRCm39)	M1K	probably null	Het
Hk1	T	C	10: 62,117,667 (GRCm39)	T619A	probably damaging	Het
Ifi44	C	T	3: 151,455,067 (GRCm39)	V53M	probably damaging	Het
Ippk	T	A	13: 49,600,011 (GRCm39)	V339D	possibly damaging	Het
Kcnma1	G	T	14: 23,387,035 (GRCm39)	N875K	possibly damaging	Het
Kdm5a	T	A	6: 120,392,251 (GRCm39)	V991E	probably damaging	Het
Larp6	A	G	9: 60,620,595 (GRCm39)	E36G	probably benign	Het
Lonp2	A	T	8: 87,435,654 (GRCm39)	D210V	probably damaging	Het
Lrrc4c	G	A	2: 97,459,378 (GRCm39)	M1I	probably null	Het
Mmp2	A	G	8: 93,559,847 (GRCm39)	K270R	probably null	Het
Nexmif	C	T	X: 103,128,360 (GRCm39)	V1186I	probably benign	Het
Or11g2	A	G	14: 50,856,468 (GRCm39)	Y263C	probably damaging	Het
Or1x2	A	T	11: 50,918,470 (GRCm39)	I214F	probably benign	Het
Pld2	T	C	11: 70,446,503 (GRCm39)	L763P	probably damaging	Het
Pold1	A	T	7: 44,187,484 (GRCm39)	F644L	probably damaging	Het
Prrc2b	T	C	2: 32,104,652 (GRCm39)	S1377P	probably damaging	Het
Rps18-ps6	T	G	13: 97,896,648 (GRCm39)	K150T	probably benign	Het
Rttn	A	G	18: 89,061,165 (GRCm39)	D1111G	probably benign	Het
Slc27a5	A	G	7: 12,728,875 (GRCm39)	V130A	probably damaging	Het
Slfn8	T	C	11: 82,908,022 (GRCm39)	R174G	probably benign	Het
Slitrk6	G	A	14: 110,989,249 (GRCm39)	P153S	probably benign	Het
Sorcs3	T	C	19: 48,642,511 (GRCm39)	I388T	probably benign	Het
Star	A	T	8: 26,302,843 (GRCm39)	T262S	possibly damaging	Het
Strn	A	T	17: 78,995,049 (GRCm39)	W2R	probably damaging	Het
Tnmd	T	C	X: 132,763,701 (GRCm39)	S172P	probably damaging	Het
Togaram2	A	G	17: 72,004,861 (GRCm39)	K305R	probably benign	Het
Trhde	C	A	10: 114,428,066 (GRCm39)	W410L	probably damaging	Het
Trim5	C	T	7: 103,928,566 (GRCm39)	R125Q	probably damaging	Het
Unc45b	C	T	11: 82,831,007 (GRCm39)		probably benign	Het
Vmn1r80	T	A	7: 11,927,379 (GRCm39)	M163K	probably benign	Het
Wnk4	C	A	11: 101,166,117 (GRCm39)		probably benign	Het
Zfp566	A	T	7: 29,777,255 (GRCm39)	C309S	probably damaging	Het
Zfp740	T	G	15: 102,121,109 (GRCm39)	F141V	possibly damaging	Het
Zfp87	T	A	13: 67,665,989 (GRCm39)	I158F	probably damaging	Het
Zswim3	C	A	2: 164,663,035 (GRCm39)	A505D	possibly damaging	Het

Other mutations in Zfp277

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01466:Zfp277	APN	12	40,428,825 (GRCm39)	missense	probably benign	0.24
IGL01477:Zfp277	APN	12	40,370,675 (GRCm39)	missense	probably benign	0.00
IGL02081:Zfp277	APN	12	40,378,795 (GRCm39)	nonsense	probably null
IGL02613:Zfp277	APN	12	40,379,514 (GRCm39)	missense	probably damaging	1.00
IGL02688:Zfp277	APN	12	40,378,687 (GRCm39)	missense	possibly damaging	0.95
IGL02825:Zfp277	APN	12	40,367,175 (GRCm39)	missense	probably benign	0.06
R0194:Zfp277	UTSW	12	40,428,876 (GRCm39)	splice site	probably benign
R0226:Zfp277	UTSW	12	40,414,161 (GRCm39)	missense	possibly damaging	0.67
R0843:Zfp277	UTSW	12	40,370,599 (GRCm39)	critical splice donor site	probably null
R1263:Zfp277	UTSW	12	40,414,164 (GRCm39)	missense	probably damaging	0.99
R1584:Zfp277	UTSW	12	40,428,825 (GRCm39)	missense	probably benign	0.12
R1609:Zfp277	UTSW	12	40,378,719 (GRCm39)	missense	probably damaging	0.99
R1644:Zfp277	UTSW	12	40,379,609 (GRCm39)	splice site	probably null
R1789:Zfp277	UTSW	12	40,414,084 (GRCm39)	missense	probably benign	0.00
R1882:Zfp277	UTSW	12	40,495,745 (GRCm39)	missense	probably benign	0.03
R2011:Zfp277	UTSW	12	40,367,217 (GRCm39)	nonsense	probably null
R4884:Zfp277	UTSW	12	40,413,152 (GRCm39)	missense	probably damaging	0.97
R4976:Zfp277	UTSW	12	40,378,687 (GRCm39)	missense	possibly damaging	0.95
R5119:Zfp277	UTSW	12	40,378,687 (GRCm39)	missense	possibly damaging	0.95
R5532:Zfp277	UTSW	12	40,385,308 (GRCm39)	missense	probably damaging	1.00
R6340:Zfp277	UTSW	12	40,368,548 (GRCm39)	missense	possibly damaging	0.57
R7191:Zfp277	UTSW	12	40,379,561 (GRCm39)	missense	probably damaging	1.00
R7378:Zfp277	UTSW	12	40,365,852 (GRCm39)	missense	possibly damaging	0.94
R7446:Zfp277	UTSW	12	40,378,729 (GRCm39)	missense	probably damaging	1.00
R7564:Zfp277	UTSW	12	40,379,594 (GRCm39)	missense	probably damaging	0.99
R7861:Zfp277	UTSW	12	40,365,880 (GRCm39)	missense	possibly damaging	0.92
R8428:Zfp277	UTSW	12	40,379,577 (GRCm39)	missense	probably damaging	1.00
R9673:Zfp277	UTSW	12	40,370,611 (GRCm39)	missense	probably benign	0.15

Posted On

2015-04-16