Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02167:Gpr137c'

282742

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr137c

Ensembl Gene

ENSMUSG00000049092

Gene Name

G protein-coupled receptor 137C

Synonyms

LOC380893, 6330416L11Rik, TM7SF1L2

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL02167

Quality Score

Status

Chromosome

Chromosomal Location

45219717-45282725 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 45279955 bp

Zygosity

Heterozygous

Amino Acid Change

Glycine to Cysteine at position 383 (G383C)

Ref Sequence

ENSEMBL: ENSMUSP00000120015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022378] [ENSMUST00000146150] [ENSMUST00000151749]

Predicted Effect

probably benign
Transcript: ENSMUST00000022378

SMART Domains

Protein: ENSMUSP00000022378
Gene: ENSMUSG00000021831

Domain	Start	End	E-Value	Type
low complexity region	2	21	N/A	INTRINSIC
Pfam:ERO1	60	453	3.7e-128	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000146150
AA Change: G383C

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000120015
Gene: ENSMUSG00000049092
AA Change: G383C

Domain	Start	End	E-Value	Type
low complexity region	4	17	N/A	INTRINSIC
low complexity region	23	39	N/A	INTRINSIC
transmembrane domain	44	66	N/A	INTRINSIC
transmembrane domain	78	100	N/A	INTRINSIC
Blast:G_alpha	121	286	9e-17	BLAST
transmembrane domain	294	316	N/A	INTRINSIC
low complexity region	376	389	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000151749

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	T	A	6: 23,122,722		probably benign	Het
Cacna1f	T	C	X: 7,616,019	Y581H	probably damaging	Het
Camsap1	C	T	2: 25,934,300	R1416H	probably damaging	Het
Ccdc117	T	C	11: 5,531,333	E266G	possibly damaging	Het
Ccdc9	A	T	7: 16,284,359	L8*	probably null	Het
Cited2	T	C	10: 17,724,270	S109P	probably benign	Het
Cnot4	T	C	6: 35,056,224	D286G	possibly damaging	Het
Col5a1	T	C	2: 28,018,556	I52T	probably benign	Het
Cry2	T	C	2: 92,433,821	N68S	possibly damaging	Het
Cul4a	T	C	8: 13,122,826	F153S	probably damaging	Het
Ddr1	T	C	17: 35,690,071	S261G	possibly damaging	Het
Depdc5	G	A	5: 32,903,801	R324Q	probably damaging	Het
Dmgdh	A	G	13: 93,720,627		probably benign	Het
Epha8	A	T	4: 136,931,094	M990K	probably damaging	Het
Hydin	T	A	8: 110,418,423	I802N	possibly damaging	Het
Ifne	A	G	4: 88,879,828	Y118H	possibly damaging	Het
Kansl2	T	C	15: 98,533,515		probably benign	Het
Lig4	T	A	8: 9,971,821	N653I	probably benign	Het
Nagk	A	G	6: 83,801,106	D246G	probably damaging	Het
Nav1	A	G	1: 135,470,961	S628P	probably damaging	Het
Ncoa3	A	G	2: 166,070,136	Y1401C	probably damaging	Het
Ndufa9	A	G	6: 126,844,785		probably benign	Het
Nynrin	G	T	14: 55,863,335	R194L	probably damaging	Het
Olfr1115	G	A	2: 87,252,198	C87Y	probably benign	Het
Olfr17	A	T	7: 107,097,661	R65S	probably benign	Het
Olfr45	T	A	7: 140,691,751	V282D	probably damaging	Het
Orc2	A	T	1: 58,483,639		probably benign	Het
Oxgr1	T	A	14: 120,021,930	R288S	probably damaging	Het
Prkcg	T	C	7: 3,322,581		probably null	Het
Prox1	T	C	1: 190,161,280	N323D	probably benign	Het
Prrt1	A	C	17: 34,631,855	E215A	possibly damaging	Het
Rab2b	T	C	14: 52,268,696	D103G	probably damaging	Het
Sardh	G	T	2: 27,191,975	N846K	probably damaging	Het
Slc38a8	T	A	8: 119,487,360	T248S	probably benign	Het
Slc6a18	T	C	13: 73,666,472		probably null	Het
Smcp	T	C	3: 92,584,199	T114A	unknown	Het
Tmem8	T	C	17: 26,119,071	S450P	probably damaging	Het
Trpv1	A	G	11: 73,254,797	N754D	probably damaging	Het
Txnrd1	A	T	10: 82,881,911	H243L	probably benign	Het
Wdfy3	T	C	5: 101,961,157	M125V	probably damaging	Het
Wnk2	T	C	13: 49,071,125		probably null	Het
Wrn	T	C	8: 33,317,555	M292V	probably damaging	Het
Zbtb17	T	C	4: 141,461,829	L20P	possibly damaging	Het
Zfp608	T	C	18: 54,988,224	H97R	probably damaging	Het
Zfp68	T	A	5: 138,606,367	M565L	probably benign	Het
Zfp687	T	C	3: 95,010,530	T644A	probably benign	Het
Zfp777	C	T	6: 48,044,526	G54D	probably damaging	Het

Other mutations in Gpr137c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00478:Gpr137c	APN	14	45278745	missense	probably damaging	0.97
IGL02203:Gpr137c	APN	14	45277487	missense	possibly damaging	0.86
IGL02960:Gpr137c	APN	14	45246433	missense	possibly damaging	0.92
R0731:Gpr137c	UTSW	14	45246349	missense	probably damaging	1.00
R1162:Gpr137c	UTSW	14	45244158	missense	possibly damaging	0.89
R1245:Gpr137c	UTSW	14	45279065	utr 3 prime	probably benign
R1983:Gpr137c	UTSW	14	45279971	missense	probably benign	0.01
R2060:Gpr137c	UTSW	14	45244159	missense	probably damaging	1.00
R2428:Gpr137c	UTSW	14	45278963	missense	probably damaging	1.00
R3034:Gpr137c	UTSW	14	45220276	missense	probably damaging	0.99
R3911:Gpr137c	UTSW	14	45278935	missense	probably benign	0.31
R4037:Gpr137c	UTSW	14	45220230	missense	probably damaging	0.99
R4038:Gpr137c	UTSW	14	45220230	missense	probably damaging	0.99
R4213:Gpr137c	UTSW	14	45246508	missense	probably damaging	0.99
R4986:Gpr137c	UTSW	14	45246286	critical splice acceptor site	probably null
R5521:Gpr137c	UTSW	14	45278694	missense	possibly damaging	0.92
R6028:Gpr137c	UTSW	14	45277481	missense	probably damaging	0.96
R7117:Gpr137c	UTSW	14	45279027	missense	probably damaging	1.00
R7238:Gpr137c	UTSW	14	45278691	missense	probably damaging	1.00
R7365:Gpr137c	UTSW	14	45279014	missense	probably damaging	1.00
X0027:Gpr137c	UTSW	14	45278669	missense	probably benign	0.14

Posted On

2015-04-16