Incidental Mutation 'IGL02167:Ifne'
ID282744
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifne
Ensembl Gene ENSMUSG00000045364
Gene Nameinterferon epsilon
SynonymsIfnt1, Ifne1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02167
Quality Score
Status
Chromosome4
Chromosomal Location88879538-88880201 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 88879828 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 118 (Y118H)
Ref Sequence ENSEMBL: ENSMUSP00000059199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056014]
Predicted Effect possibly damaging
Transcript: ENSMUST00000056014
AA Change: Y118H

PolyPhen 2 Score 0.577 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000059199
Gene: ENSMUSG00000045364
AA Change: Y118H

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 37 51 N/A INTRINSIC
IFabd 58 175 2.09e-22 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to HSV-2 and Chlamydia infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,122,722 probably benign Het
Cacna1f T C X: 7,616,019 Y581H probably damaging Het
Camsap1 C T 2: 25,934,300 R1416H probably damaging Het
Ccdc117 T C 11: 5,531,333 E266G possibly damaging Het
Ccdc9 A T 7: 16,284,359 L8* probably null Het
Cited2 T C 10: 17,724,270 S109P probably benign Het
Cnot4 T C 6: 35,056,224 D286G possibly damaging Het
Col5a1 T C 2: 28,018,556 I52T probably benign Het
Cry2 T C 2: 92,433,821 N68S possibly damaging Het
Cul4a T C 8: 13,122,826 F153S probably damaging Het
Ddr1 T C 17: 35,690,071 S261G possibly damaging Het
Depdc5 G A 5: 32,903,801 R324Q probably damaging Het
Dmgdh A G 13: 93,720,627 probably benign Het
Epha8 A T 4: 136,931,094 M990K probably damaging Het
Gpr137c G T 14: 45,279,955 G383C probably damaging Het
Hydin T A 8: 110,418,423 I802N possibly damaging Het
Kansl2 T C 15: 98,533,515 probably benign Het
Lig4 T A 8: 9,971,821 N653I probably benign Het
Nagk A G 6: 83,801,106 D246G probably damaging Het
Nav1 A G 1: 135,470,961 S628P probably damaging Het
Ncoa3 A G 2: 166,070,136 Y1401C probably damaging Het
Ndufa9 A G 6: 126,844,785 probably benign Het
Nynrin G T 14: 55,863,335 R194L probably damaging Het
Olfr1115 G A 2: 87,252,198 C87Y probably benign Het
Olfr17 A T 7: 107,097,661 R65S probably benign Het
Olfr45 T A 7: 140,691,751 V282D probably damaging Het
Orc2 A T 1: 58,483,639 probably benign Het
Oxgr1 T A 14: 120,021,930 R288S probably damaging Het
Prkcg T C 7: 3,322,581 probably null Het
Prox1 T C 1: 190,161,280 N323D probably benign Het
Prrt1 A C 17: 34,631,855 E215A possibly damaging Het
Rab2b T C 14: 52,268,696 D103G probably damaging Het
Sardh G T 2: 27,191,975 N846K probably damaging Het
Slc38a8 T A 8: 119,487,360 T248S probably benign Het
Slc6a18 T C 13: 73,666,472 probably null Het
Smcp T C 3: 92,584,199 T114A unknown Het
Tmem8 T C 17: 26,119,071 S450P probably damaging Het
Trpv1 A G 11: 73,254,797 N754D probably damaging Het
Txnrd1 A T 10: 82,881,911 H243L probably benign Het
Wdfy3 T C 5: 101,961,157 M125V probably damaging Het
Wnk2 T C 13: 49,071,125 probably null Het
Wrn T C 8: 33,317,555 M292V probably damaging Het
Zbtb17 T C 4: 141,461,829 L20P possibly damaging Het
Zfp608 T C 18: 54,988,224 H97R probably damaging Het
Zfp68 T A 5: 138,606,367 M565L probably benign Het
Zfp687 T C 3: 95,010,530 T644A probably benign Het
Zfp777 C T 6: 48,044,526 G54D probably damaging Het
Other mutations in Ifne
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00594:Ifne APN 4 88879804 missense probably benign 0.01
IGL00978:Ifne APN 4 88880031 missense probably benign 0.17
R0212:Ifne UTSW 4 88879735 missense possibly damaging 0.95
R0699:Ifne UTSW 4 88879777 missense probably benign 0.00
R1868:Ifne UTSW 4 88879671 missense probably damaging 1.00
R4480:Ifne UTSW 4 88879601 makesense probably null
R4865:Ifne UTSW 4 88879705 missense probably damaging 1.00
R6752:Ifne UTSW 4 88880082 missense probably benign 0.06
R7319:Ifne UTSW 4 88880006 missense probably damaging 0.98
R7413:Ifne UTSW 4 88879603 makesense probably null
Posted On2015-04-16