Incidental Mutation 'IGL02167:Or10a4'
ID 282750
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10a4
Ensembl Gene ENSMUSG00000073897
Gene Name olfactory receptor family 10 subfamily A member 4
Synonyms MOR263-5, GA_x6K02T2PBJ9-9470146-9471093, Olfr17, P2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # IGL02167
Quality Score
Status
Chromosome 7
Chromosomal Location 106696674-106697621 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 106696868 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 65 (R65S)
Ref Sequence ENSEMBL: ENSMUSP00000147931 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098138] [ENSMUST00000210568]
AlphaFold Q7TRM9
Predicted Effect probably benign
Transcript: ENSMUST00000098138
AA Change: R65S

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000095741
Gene: ENSMUSG00000073897
AA Change: R65S

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.6e-58 PFAM
Pfam:7tm_1 42 291 2.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210568
AA Change: R65S

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene possess olfactory neurons whose axons fail to project to the appropriate glomeruli in the olfactopry bulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,122,721 (GRCm39) probably benign Het
Cacna1f T C X: 7,482,258 (GRCm39) Y581H probably damaging Het
Camsap1 C T 2: 25,824,312 (GRCm39) R1416H probably damaging Het
Ccdc117 T C 11: 5,481,333 (GRCm39) E266G possibly damaging Het
Ccdc9 A T 7: 16,018,284 (GRCm39) L8* probably null Het
Cited2 T C 10: 17,600,018 (GRCm39) S109P probably benign Het
Cnot4 T C 6: 35,033,159 (GRCm39) D286G possibly damaging Het
Col5a1 T C 2: 27,908,568 (GRCm39) I52T probably benign Het
Cry2 T C 2: 92,264,166 (GRCm39) N68S possibly damaging Het
Cul4a T C 8: 13,172,826 (GRCm39) F153S probably damaging Het
Ddr1 T C 17: 36,000,963 (GRCm39) S261G possibly damaging Het
Depdc5 G A 5: 33,061,145 (GRCm39) R324Q probably damaging Het
Dmgdh A G 13: 93,857,135 (GRCm39) probably benign Het
Epha8 A T 4: 136,658,405 (GRCm39) M990K probably damaging Het
Gpr137c G T 14: 45,517,412 (GRCm39) G383C probably damaging Het
Hydin T A 8: 111,145,055 (GRCm39) I802N possibly damaging Het
Ifne A G 4: 88,798,065 (GRCm39) Y118H possibly damaging Het
Kansl2 T C 15: 98,431,396 (GRCm39) probably benign Het
Lig4 T A 8: 10,021,821 (GRCm39) N653I probably benign Het
Nagk A G 6: 83,778,088 (GRCm39) D246G probably damaging Het
Nav1 A G 1: 135,398,699 (GRCm39) S628P probably damaging Het
Ncoa3 A G 2: 165,912,056 (GRCm39) Y1401C probably damaging Het
Ndufa9 A G 6: 126,821,748 (GRCm39) probably benign Het
Nynrin G T 14: 56,100,792 (GRCm39) R194L probably damaging Het
Or10ag53 G A 2: 87,082,542 (GRCm39) C87Y probably benign Het
Or13a17 T A 7: 140,271,664 (GRCm39) V282D probably damaging Het
Orc2 A T 1: 58,522,798 (GRCm39) probably benign Het
Oxgr1 T A 14: 120,259,342 (GRCm39) R288S probably damaging Het
Pgap6 T C 17: 26,338,045 (GRCm39) S450P probably damaging Het
Prkcg T C 7: 3,371,097 (GRCm39) probably null Het
Prox1 T C 1: 189,893,477 (GRCm39) N323D probably benign Het
Prrt1 A C 17: 34,850,829 (GRCm39) E215A possibly damaging Het
Rab2b T C 14: 52,506,153 (GRCm39) D103G probably damaging Het
Sardh G T 2: 27,081,987 (GRCm39) N846K probably damaging Het
Slc38a8 T A 8: 120,214,099 (GRCm39) T248S probably benign Het
Slc6a18 T C 13: 73,814,591 (GRCm39) probably null Het
Smcp T C 3: 92,491,506 (GRCm39) T114A unknown Het
Trpv1 A G 11: 73,145,623 (GRCm39) N754D probably damaging Het
Txnrd1 A T 10: 82,717,745 (GRCm39) H243L probably benign Het
Wdfy3 T C 5: 102,109,023 (GRCm39) M125V probably damaging Het
Wnk2 T C 13: 49,224,601 (GRCm39) probably null Het
Wrn T C 8: 33,807,583 (GRCm39) M292V probably damaging Het
Zbtb17 T C 4: 141,189,140 (GRCm39) L20P possibly damaging Het
Zfp608 T C 18: 55,121,296 (GRCm39) H97R probably damaging Het
Zfp68 T A 5: 138,604,629 (GRCm39) M565L probably benign Het
Zfp687 T C 3: 94,917,841 (GRCm39) T644A probably benign Het
Zfp777 C T 6: 48,021,460 (GRCm39) G54D probably damaging Het
Other mutations in Or10a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0540:Or10a4 UTSW 7 106,696,933 (GRCm39) missense probably benign 0.25
R0607:Or10a4 UTSW 7 106,696,933 (GRCm39) missense probably benign 0.25
R1566:Or10a4 UTSW 7 106,696,759 (GRCm39) missense probably damaging 1.00
R1667:Or10a4 UTSW 7 106,696,977 (GRCm39) missense probably benign 0.00
R2122:Or10a4 UTSW 7 106,697,316 (GRCm39) missense probably damaging 1.00
R3800:Or10a4 UTSW 7 106,696,938 (GRCm39) nonsense probably null
R3825:Or10a4 UTSW 7 106,696,816 (GRCm39) missense possibly damaging 0.88
R4722:Or10a4 UTSW 7 106,696,777 (GRCm39) missense possibly damaging 0.88
R6253:Or10a4 UTSW 7 106,697,464 (GRCm39) missense possibly damaging 0.48
R6470:Or10a4 UTSW 7 106,696,951 (GRCm39) missense probably damaging 1.00
R7214:Or10a4 UTSW 7 106,697,619 (GRCm39) makesense probably null
R8976:Or10a4 UTSW 7 106,697,466 (GRCm39) missense possibly damaging 0.56
R9731:Or10a4 UTSW 7 106,696,786 (GRCm39) missense probably benign 0.00
Z1177:Or10a4 UTSW 7 106,697,048 (GRCm39) missense probably benign
Posted On 2015-04-16