Incidental Mutation 'IGL02167:Zfp68'
ID282771
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp68
Ensembl Gene ENSMUSG00000058291
Gene Namezinc finger protein 68
SynonymsZfp68, Zfp70, KRAZ2, KRAB3
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.849) question?
Stock #IGL02167
Quality Score
Status
Chromosome5
Chromosomal Location138603652-138619761 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 138606367 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 565 (M565L)
Ref Sequence ENSEMBL: ENSMUSP00000069615 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063262] [ENSMUST00000085852] [ENSMUST00000110905]
Predicted Effect probably benign
Transcript: ENSMUST00000063262
AA Change: M565L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000069615
Gene: ENSMUSG00000058291
AA Change: M565L

DomainStartEndE-ValueType
KRAB 10 70 1.11e-30 SMART
ZnF_C2H2 317 339 1.58e-3 SMART
ZnF_C2H2 345 367 3.16e-3 SMART
ZnF_C2H2 373 395 5.5e-3 SMART
ZnF_C2H2 401 423 2.27e-4 SMART
ZnF_C2H2 429 451 3.44e-4 SMART
ZnF_C2H2 457 479 3.07e-1 SMART
ZnF_C2H2 485 507 2.09e-3 SMART
ZnF_C2H2 513 535 3.29e-1 SMART
ZnF_C2H2 541 563 2.99e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000085852
AA Change: M527L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000083013
Gene: ENSMUSG00000058291
AA Change: M527L

DomainStartEndE-ValueType
KRAB 1 32 6e-1 SMART
ZnF_C2H2 279 301 1.58e-3 SMART
ZnF_C2H2 307 329 3.16e-3 SMART
ZnF_C2H2 335 357 5.5e-3 SMART
ZnF_C2H2 363 385 2.27e-4 SMART
ZnF_C2H2 391 413 3.44e-4 SMART
ZnF_C2H2 419 441 3.07e-1 SMART
ZnF_C2H2 447 469 2.09e-3 SMART
ZnF_C2H2 475 497 3.29e-1 SMART
ZnF_C2H2 503 525 2.99e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110905
AA Change: M565L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000106530
Gene: ENSMUSG00000058291
AA Change: M565L

DomainStartEndE-ValueType
KRAB 10 70 1.11e-30 SMART
ZnF_C2H2 317 339 1.58e-3 SMART
ZnF_C2H2 345 367 3.16e-3 SMART
ZnF_C2H2 373 395 5.5e-3 SMART
ZnF_C2H2 401 423 2.27e-4 SMART
ZnF_C2H2 429 451 3.44e-4 SMART
ZnF_C2H2 457 479 3.07e-1 SMART
ZnF_C2H2 485 507 2.09e-3 SMART
ZnF_C2H2 513 535 3.29e-1 SMART
ZnF_C2H2 541 563 2.99e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119137
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175175
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197654
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T A 6: 23,122,722 probably benign Het
Cacna1f T C X: 7,616,019 Y581H probably damaging Het
Camsap1 C T 2: 25,934,300 R1416H probably damaging Het
Ccdc117 T C 11: 5,531,333 E266G possibly damaging Het
Ccdc9 A T 7: 16,284,359 L8* probably null Het
Cited2 T C 10: 17,724,270 S109P probably benign Het
Cnot4 T C 6: 35,056,224 D286G possibly damaging Het
Col5a1 T C 2: 28,018,556 I52T probably benign Het
Cry2 T C 2: 92,433,821 N68S possibly damaging Het
Cul4a T C 8: 13,122,826 F153S probably damaging Het
Ddr1 T C 17: 35,690,071 S261G possibly damaging Het
Depdc5 G A 5: 32,903,801 R324Q probably damaging Het
Dmgdh A G 13: 93,720,627 probably benign Het
Epha8 A T 4: 136,931,094 M990K probably damaging Het
Gpr137c G T 14: 45,279,955 G383C probably damaging Het
Hydin T A 8: 110,418,423 I802N possibly damaging Het
Ifne A G 4: 88,879,828 Y118H possibly damaging Het
Kansl2 T C 15: 98,533,515 probably benign Het
Lig4 T A 8: 9,971,821 N653I probably benign Het
Nagk A G 6: 83,801,106 D246G probably damaging Het
Nav1 A G 1: 135,470,961 S628P probably damaging Het
Ncoa3 A G 2: 166,070,136 Y1401C probably damaging Het
Ndufa9 A G 6: 126,844,785 probably benign Het
Nynrin G T 14: 55,863,335 R194L probably damaging Het
Olfr1115 G A 2: 87,252,198 C87Y probably benign Het
Olfr17 A T 7: 107,097,661 R65S probably benign Het
Olfr45 T A 7: 140,691,751 V282D probably damaging Het
Orc2 A T 1: 58,483,639 probably benign Het
Oxgr1 T A 14: 120,021,930 R288S probably damaging Het
Prkcg T C 7: 3,322,581 probably null Het
Prox1 T C 1: 190,161,280 N323D probably benign Het
Prrt1 A C 17: 34,631,855 E215A possibly damaging Het
Rab2b T C 14: 52,268,696 D103G probably damaging Het
Sardh G T 2: 27,191,975 N846K probably damaging Het
Slc38a8 T A 8: 119,487,360 T248S probably benign Het
Slc6a18 T C 13: 73,666,472 probably null Het
Smcp T C 3: 92,584,199 T114A unknown Het
Tmem8 T C 17: 26,119,071 S450P probably damaging Het
Trpv1 A G 11: 73,254,797 N754D probably damaging Het
Txnrd1 A T 10: 82,881,911 H243L probably benign Het
Wdfy3 T C 5: 101,961,157 M125V probably damaging Het
Wnk2 T C 13: 49,071,125 probably null Het
Wrn T C 8: 33,317,555 M292V probably damaging Het
Zbtb17 T C 4: 141,461,829 L20P possibly damaging Het
Zfp608 T C 18: 54,988,224 H97R probably damaging Het
Zfp687 T C 3: 95,010,530 T644A probably benign Het
Zfp777 C T 6: 48,044,526 G54D probably damaging Het
Other mutations in Zfp68
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0040:Zfp68 UTSW 5 138607779 missense probably benign 0.24
R0040:Zfp68 UTSW 5 138607779 missense probably benign 0.24
R0152:Zfp68 UTSW 5 138606613 missense probably damaging 1.00
R0390:Zfp68 UTSW 5 138607225 missense probably benign 0.14
R1490:Zfp68 UTSW 5 138606829 missense probably benign 0.16
R4688:Zfp68 UTSW 5 138616481 nonsense probably null
R4992:Zfp68 UTSW 5 138607337 missense possibly damaging 0.50
R5072:Zfp68 UTSW 5 138606317 missense probably benign 0.01
R7076:Zfp68 UTSW 5 138606939 missense possibly damaging 0.49
R7117:Zfp68 UTSW 5 138606318 missense probably benign 0.01
R7332:Zfp68 UTSW 5 138606568 missense possibly damaging 0.90
R8399:Zfp68 UTSW 5 138607820 missense probably benign 0.02
Posted On2015-04-16