Incidental Mutation 'IGL02169:Olfr703'
ID282812
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr703
Ensembl Gene ENSMUSG00000073901
Gene Nameolfactory receptor 703
SynonymsMOR283-7, GA_x6K02T2PBJ9-9222217-9223176
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.243) question?
Stock #IGL02169
Quality Score
Status
Chromosome7
Chromosomal Location106843360-106846207 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 106845266 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 218 (Y218*)
Ref Sequence ENSEMBL: ENSMUSP00000149022 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098142] [ENSMUST00000216254]
Predicted Effect probably null
Transcript: ENSMUST00000098142
AA Change: Y218*
SMART Domains Protein: ENSMUSP00000095746
Gene: ENSMUSG00000073901
AA Change: Y218*

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.8e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.4e-8 PFAM
Pfam:7tm_1 41 290 1.7e-27 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000216254
AA Change: Y218*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,952,582 I1001F probably damaging Het
Amfr A T 8: 94,005,230 probably null Het
Apol7c T G 15: 77,526,416 D110A possibly damaging Het
Bcr A G 10: 75,159,882 N899S probably benign Het
Ccnt2 T A 1: 127,774,389 probably benign Het
Clptm1l G A 13: 73,611,663 V281I probably damaging Het
Ctsr A G 13: 61,163,240 probably benign Het
Dbh G A 2: 27,174,898 V374M probably damaging Het
Eif3b A G 5: 140,430,081 D385G possibly damaging Het
F830045P16Rik A G 2: 129,463,572 V294A probably damaging Het
Foxj2 A G 6: 122,828,466 N99S probably damaging Het
Gabrr1 T G 4: 33,160,261 V315G probably damaging Het
Gm21988 T C 11: 70,238,938 E25G probably benign Het
Islr A T 9: 58,158,132 F31I possibly damaging Het
L2hgdh A T 12: 69,721,397 L109Q probably damaging Het
Lrp6 A G 6: 134,513,327 I96T probably damaging Het
Nup93 A G 8: 94,302,129 D330G probably damaging Het
Olfr1080 T C 2: 86,553,882 M81V probably benign Het
Phtf1 C A 3: 103,997,499 L488I probably benign Het
Plac8l1 T C 18: 42,178,943 D137G probably damaging Het
Pth1r G A 9: 110,724,435 T392I probably damaging Het
Rab43 A G 6: 87,811,424 F41L probably damaging Het
Ralgapb C T 2: 158,426,204 L76F probably damaging Het
Ros1 A G 10: 52,081,957 probably null Het
Rpl27a T C 7: 109,519,978 I43T probably benign Het
Set G A 2: 30,069,524 D129N possibly damaging Het
Sorbs2 A T 8: 45,823,749 Y604F probably damaging Het
Tg T C 15: 66,757,943 V491A probably benign Het
Txlna T C 4: 129,629,613 T429A probably damaging Het
Vmn1r128 C T 7: 21,350,238 P289L probably damaging Het
Wfs1 A G 5: 36,968,479 F356S probably damaging Het
Zfp687 G A 3: 95,011,432 T343I probably damaging Het
Zfp935 A G 13: 62,456,931 probably null Het
Other mutations in Olfr703
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Olfr703 APN 7 106845367 missense possibly damaging 0.78
IGL01321:Olfr703 APN 7 106844749 missense probably damaging 1.00
IGL03376:Olfr703 APN 7 106845470 missense probably damaging 1.00
R0045:Olfr703 UTSW 7 106845389 nonsense probably null
R0662:Olfr703 UTSW 7 106844649 missense probably benign 0.01
R1589:Olfr703 UTSW 7 106845196 missense possibly damaging 0.57
R1869:Olfr703 UTSW 7 106845094 missense probably benign 0.01
R2431:Olfr703 UTSW 7 106845391 missense possibly damaging 0.95
R4021:Olfr703 UTSW 7 106845019 missense probably damaging 1.00
R5280:Olfr703 UTSW 7 106844695 missense probably benign 0.01
R6352:Olfr703 UTSW 7 106845222 missense probably damaging 1.00
R6932:Olfr703 UTSW 7 106844802 nonsense probably null
R7037:Olfr703 UTSW 7 106845336 missense probably damaging 1.00
R7909:Olfr703 UTSW 7 106844992 missense probably benign 0.29
Posted On2015-04-16