Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02169:Gm21988'

282817

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm21988

Ensembl Gene

ENSMUSG00000040904

Gene Name

predicted gene 21988

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02169

Quality Score

Status

Chromosome

Chromosomal Location

70126032-70130656 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 70129764 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 25 (E25G)

Ref Sequence

ENSEMBL: ENSMUSP00000135134 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000329] [ENSMUST00000021180] [ENSMUST00000021181] [ENSMUST00000040428] [ENSMUST00000100950] [ENSMUST00000176116] [ENSMUST00000141880] [ENSMUST00000125752] [ENSMUST00000108579] [ENSMUST00000108575] [ENSMUST00000108578] [ENSMUST00000108576] [ENSMUST00000108577] [ENSMUST00000102569] [ENSMUST00000176268]

AlphaFold

Q8K3C0

Predicted Effect

probably benign
Transcript: ENSMUST00000000329

SMART Domains

Protein: ENSMUSP00000000329
Gene: ENSMUSG00000000320

Domain	Start	End	E-Value	Type
LH2	2	111	9.78e-40	SMART
Pfam:Lipoxygenase	172	650	5.1e-63	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000021180

SMART Domains

Protein: ENSMUSP00000021180
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
Blast:SANT	38	69	1e-16	BLAST
SCOP:d1ba5__	41	59	9e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000021181

SMART Domains

Protein: ENSMUSP00000021181
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
SANT	38	83	7.29e-1	SMART
low complexity region	106	129	N/A	INTRINSIC
low complexity region	135	150	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000040428
AA Change: E52G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000048271
Gene: ENSMUSG00000093989
AA Change: E52G

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
transmembrane domain	65	87	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000083477

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000093601

Predicted Effect

probably benign
Transcript: ENSMUST00000100950

SMART Domains

Protein: ENSMUSP00000098510
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
SANT	37	82	7.29e-1	SMART
low complexity region	105	128	N/A	INTRINSIC
low complexity region	134	149	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000176116
AA Change: E25G

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000135134
Gene: ENSMUSG00000040904
AA Change: E25G

Domain	Start	End	E-Value	Type
transmembrane domain	38	60	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000141880
AA Change: E25G

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000135383
Gene: ENSMUSG00000093989
AA Change: E25G

Domain	Start	End	E-Value	Type
transmembrane domain	38	60	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000125752

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148878

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138658

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150504

Predicted Effect

probably benign
Transcript: ENSMUST00000134700

SMART Domains

Protein: ENSMUSP00000119483
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
low complexity region	43	66	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108579

SMART Domains

Protein: ENSMUSP00000104220
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
low complexity region	72	95	N/A	INTRINSIC
low complexity region	101	116	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000135390

SMART Domains

Protein: ENSMUSP00000134994
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
low complexity region	29	52	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108575

SMART Domains

Protein: ENSMUSP00000104215
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
low complexity region	72	95	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108578

SMART Domains

Protein: ENSMUSP00000104219
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
SANT	38	83	7.29e-1	SMART
low complexity region	106	129	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108576

SMART Domains

Protein: ENSMUSP00000104216
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
SANT	38	83	7.29e-1	SMART
low complexity region	106	129	N/A	INTRINSIC
low complexity region	169	183	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108577

SMART Domains

Protein: ENSMUSP00000104218
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
low complexity region	72	95	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000102569

SMART Domains

Protein: ENSMUSP00000099629
Gene: ENSMUSG00000020831

Domain	Start	End	E-Value	Type
low complexity region	72	95	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000176268
AA Change: E52G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000135088
Gene: ENSMUSG00000040904
AA Change: E52G

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
transmembrane domain	65	87	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200557

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	T	A	11: 109,843,408 (GRCm39)	I1001F	probably damaging	Het
Amfr	A	T	8: 94,731,858 (GRCm39)		probably null	Het
Apol7c	T	G	15: 77,410,616 (GRCm39)	D110A	possibly damaging	Het
Bcr	A	G	10: 74,995,714 (GRCm39)	N899S	probably benign	Het
Ccnt2	T	A	1: 127,702,126 (GRCm39)		probably benign	Het
Clptm1l	G	A	13: 73,759,782 (GRCm39)	V281I	probably damaging	Het
Ctsr	A	G	13: 61,311,054 (GRCm39)		probably benign	Het
Dbh	G	A	2: 27,064,910 (GRCm39)	V374M	probably damaging	Het
Eif3b	A	G	5: 140,415,836 (GRCm39)	D385G	possibly damaging	Het
F830045P16Rik	A	G	2: 129,305,492 (GRCm39)	V294A	probably damaging	Het
Foxj2	A	G	6: 122,805,425 (GRCm39)	N99S	probably damaging	Het
Gabrr1	T	G	4: 33,160,261 (GRCm39)	V315G	probably damaging	Het
Islr	A	T	9: 58,065,415 (GRCm39)	F31I	possibly damaging	Het
L2hgdh	A	T	12: 69,768,171 (GRCm39)	L109Q	probably damaging	Het
Lrp6	A	G	6: 134,490,290 (GRCm39)	I96T	probably damaging	Het
Nup93	A	G	8: 95,028,757 (GRCm39)	D330G	probably damaging	Het
Or2ag19	T	A	7: 106,444,473 (GRCm39)	Y218*	probably null	Het
Or8k33	T	C	2: 86,384,226 (GRCm39)	M81V	probably benign	Het
Phtf1	C	A	3: 103,904,815 (GRCm39)	L488I	probably benign	Het
Plac8l1	T	C	18: 42,312,008 (GRCm39)	D137G	probably damaging	Het
Pth1r	G	A	9: 110,553,503 (GRCm39)	T392I	probably damaging	Het
Rab43	A	G	6: 87,788,406 (GRCm39)	F41L	probably damaging	Het
Ralgapb	C	T	2: 158,268,124 (GRCm39)	L76F	probably damaging	Het
Ros1	A	G	10: 51,958,053 (GRCm39)		probably null	Het
Rpl27a	T	C	7: 109,119,185 (GRCm39)	I43T	probably benign	Het
Set	G	A	2: 29,959,536 (GRCm39)	D129N	possibly damaging	Het
Sorbs2	A	T	8: 46,276,786 (GRCm39)	Y604F	probably damaging	Het
Tg	T	C	15: 66,629,792 (GRCm39)	V491A	probably benign	Het
Txlna	T	C	4: 129,523,406 (GRCm39)	T429A	probably damaging	Het
Vmn1r128	C	T	7: 21,084,163 (GRCm39)	P289L	probably damaging	Het
Wfs1	A	G	5: 37,125,823 (GRCm39)	F356S	probably damaging	Het
Zfp687	G	A	3: 94,918,743 (GRCm39)	T343I	probably damaging	Het
Zfp935	A	G	13: 62,604,745 (GRCm39)		probably null	Het

Posted On

2015-04-16