Incidental Mutation 'IGL00557:Agpat3'
ID 28283
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Agpat3
Ensembl Gene ENSMUSG00000001211
Gene Name 1-acylglycerol-3-phosphate O-acyltransferase 3
Synonyms D10Jhu12e, LPAAT3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # IGL00557
Quality Score
Status
Chromosome 10
Chromosomal Location 78105012-78188323 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) A to T at 78109516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132954 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001240] [ENSMUST00000105387] [ENSMUST00000105388] [ENSMUST00000105389] [ENSMUST00000105390] [ENSMUST00000166360]
AlphaFold Q9D517
Predicted Effect probably benign
Transcript: ENSMUST00000001240
SMART Domains Protein: ENSMUSP00000001240
Gene: ENSMUSG00000001211

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
PlsC 90 212 3.14e-21 SMART
transmembrane domain 308 330 N/A INTRINSIC
transmembrane domain 335 357 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105387
SMART Domains Protein: ENSMUSP00000101026
Gene: ENSMUSG00000001211

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
PlsC 90 212 3.14e-21 SMART
transmembrane domain 308 330 N/A INTRINSIC
transmembrane domain 335 357 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105388
SMART Domains Protein: ENSMUSP00000101027
Gene: ENSMUSG00000001211

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
PlsC 90 212 3.14e-21 SMART
transmembrane domain 308 330 N/A INTRINSIC
transmembrane domain 335 357 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105389
SMART Domains Protein: ENSMUSP00000101028
Gene: ENSMUSG00000001211

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
PlsC 90 212 3.14e-21 SMART
transmembrane domain 308 330 N/A INTRINSIC
transmembrane domain 335 357 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105390
SMART Domains Protein: ENSMUSP00000101029
Gene: ENSMUSG00000001211

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
PlsC 90 212 3.14e-21 SMART
transmembrane domain 308 330 N/A INTRINSIC
transmembrane domain 335 357 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146296
Predicted Effect probably benign
Transcript: ENSMUST00000166360
SMART Domains Protein: ENSMUSP00000132954
Gene: ENSMUSG00000001211

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
PlsC 90 212 3.14e-21 SMART
Pfam:Acyltransf_C 241 314 2.1e-29 PFAM
transmembrane domain 335 357 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, teratozoospermia. [provided by MGI curators]
Allele List at MGI

All alleles(14) : Targeted(2) Gene trapped(12)

Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap35 T C 7: 16,298,340 (GRCm39) T242A probably benign Het
Asb15 C A 6: 24,558,649 (GRCm39) R55S probably benign Het
Brca2 C T 5: 150,484,003 (GRCm39) R2941W probably benign Het
Chrng T C 1: 87,134,469 (GRCm39) V135A probably damaging Het
Corin G T 5: 72,462,231 (GRCm39) H859Q probably damaging Het
Cul7 A G 17: 46,963,434 (GRCm39) E208G probably damaging Het
Dnah6 T C 6: 73,172,603 (GRCm39) N285S possibly damaging Het
Ell2 T A 13: 75,904,409 (GRCm39) I166N probably damaging Het
Fsip2 A G 2: 82,821,657 (GRCm39) R5797G possibly damaging Het
Galntl6 T C 8: 59,364,451 (GRCm39) I20V possibly damaging Het
Glra2 A G X: 164,072,633 (GRCm39) F78L possibly damaging Het
Gm12258 A G 11: 58,746,896 (GRCm39) D51G probably benign Het
Gsta2 T A 9: 78,238,525 (GRCm39) K185* probably null Het
Hmgcr C T 13: 96,795,786 (GRCm39) D294N probably benign Het
Iglv2 A G 16: 19,079,547 (GRCm39) probably benign Het
Myo10 T A 15: 25,776,466 (GRCm39) L63H probably damaging Het
P2ry10b T C X: 106,215,243 (GRCm39) V201A probably benign Het
Psmb2 A G 4: 126,571,642 (GRCm39) probably null Het
Samd4 T A 14: 47,290,355 (GRCm39) L154H probably damaging Het
Sult2a4 A T 7: 13,718,870 (GRCm39) D124E probably damaging Het
Trav9-1 A T 14: 53,725,815 (GRCm39) Y43F probably damaging Het
Trpv2 A G 11: 62,483,681 (GRCm39) N506S probably damaging Het
Ube3c T C 5: 29,824,227 (GRCm39) S474P probably damaging Het
Wdr87-ps A G 7: 29,235,227 (GRCm39) noncoding transcript Het
Zfp942 A T 17: 22,148,042 (GRCm39) C196S probably benign Het
Other mutations in Agpat3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02621:Agpat3 APN 10 78,120,900 (GRCm39) missense probably damaging 1.00
IGL02725:Agpat3 APN 10 78,113,889 (GRCm39) missense probably benign 0.02
P0008:Agpat3 UTSW 10 78,123,710 (GRCm39) missense probably damaging 1.00
PIT4445001:Agpat3 UTSW 10 78,109,927 (GRCm39) missense possibly damaging 0.94
R0041:Agpat3 UTSW 10 78,123,881 (GRCm39) unclassified probably benign
R0126:Agpat3 UTSW 10 78,113,890 (GRCm39) missense probably null 0.59
R0226:Agpat3 UTSW 10 78,113,863 (GRCm39) missense possibly damaging 0.89
R1520:Agpat3 UTSW 10 78,123,857 (GRCm39) start codon destroyed probably null 1.00
R2118:Agpat3 UTSW 10 78,113,918 (GRCm39) missense probably damaging 1.00
R5493:Agpat3 UTSW 10 78,120,069 (GRCm39) missense possibly damaging 0.89
R5599:Agpat3 UTSW 10 78,110,103 (GRCm39) missense probably benign 0.39
R6280:Agpat3 UTSW 10 78,120,872 (GRCm39) missense probably damaging 1.00
R7528:Agpat3 UTSW 10 78,123,746 (GRCm39) missense probably damaging 1.00
R7895:Agpat3 UTSW 10 78,119,034 (GRCm39) missense probably benign 0.34
R8351:Agpat3 UTSW 10 78,110,086 (GRCm39) missense probably damaging 1.00
R8425:Agpat3 UTSW 10 78,118,211 (GRCm39) missense possibly damaging 0.89
R8949:Agpat3 UTSW 10 78,118,989 (GRCm39) missense probably benign 0.00
R9136:Agpat3 UTSW 10 78,120,893 (GRCm39) missense probably damaging 1.00
X0003:Agpat3 UTSW 10 78,110,007 (GRCm39) nonsense probably null
Posted On 2013-04-17