Incidental Mutation 'IGL02170:Hspa12a'
ID 282878
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hspa12a
Ensembl Gene ENSMUSG00000025092
Gene Name heat shock protein 12A
Synonyms Hspa12a, 1700063D12Rik, Gm19925
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.392) question?
Stock # IGL02170
Quality Score
Status
Chromosome 19
Chromosomal Location 58784182-58932086 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 58793113 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 357 (K357N)
Ref Sequence ENSEMBL: ENSMUSP00000066860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066285]
AlphaFold Q8K0U4
Predicted Effect probably benign
Transcript: ENSMUST00000066285
AA Change: K357N

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000066860
Gene: ENSMUSG00000025092
AA Change: K357N

DomainStartEndE-ValueType
SCOP:d1bupa1 58 244 4e-14 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik G A 16: 16,936,196 (GRCm39) P176L probably damaging Het
4932414N04Rik A G 2: 68,561,467 (GRCm39) M265V probably benign Het
A2ml1 T C 6: 128,524,173 (GRCm39) E1153G possibly damaging Het
Adam22 T C 5: 8,184,845 (GRCm39) T452A probably benign Het
Ambra1 A G 2: 91,597,432 (GRCm39) T56A possibly damaging Het
Atp1a4 A G 1: 172,062,103 (GRCm39) V674A possibly damaging Het
Ccnb1 A T 13: 100,919,994 (GRCm39) Y172* probably null Het
Chrdl2 A T 7: 99,683,821 (GRCm39) T416S possibly damaging Het
Col6a5 A G 9: 105,805,621 (GRCm39) L1095P unknown Het
Dhx16 T C 17: 36,200,361 (GRCm39) C901R probably damaging Het
Dip2c A G 13: 9,656,371 (GRCm39) T732A probably benign Het
Dnah12 A C 14: 26,495,069 (GRCm39) I1376L probably damaging Het
Dock2 A T 11: 34,217,949 (GRCm39) L1207Q probably damaging Het
Eif2ak1 A T 5: 143,816,278 (GRCm39) H192L probably benign Het
Evi5 T A 5: 107,969,750 (GRCm39) T54S probably benign Het
Fam151a T C 4: 106,592,795 (GRCm39) probably null Het
Fam98a C T 17: 75,847,187 (GRCm39) probably null Het
Frmd4a G A 2: 4,570,988 (GRCm39) R306K probably damaging Het
Fxyd7 C A 7: 30,744,432 (GRCm39) V28L possibly damaging Het
Gabrb1 T A 5: 72,294,073 (GRCm39) I449K probably damaging Het
Gkn3 G T 6: 87,360,493 (GRCm39) D167E possibly damaging Het
Gm14496 A T 2: 181,638,144 (GRCm39) Y406F probably damaging Het
Gm8603 T A 17: 13,737,073 (GRCm39) noncoding transcript Het
Hecw1 T C 13: 14,438,743 (GRCm39) N880S possibly damaging Het
Hivep2 C A 10: 14,003,548 (GRCm39) Q49K possibly damaging Het
Hscb T A 5: 110,987,492 (GRCm39) S35C probably damaging Het
Kcnu1 A T 8: 26,427,588 (GRCm39) I302F probably damaging Het
Krtap5-3 T A 7: 141,756,215 (GRCm39) C351S unknown Het
Mvd A G 8: 123,164,747 (GRCm39) V142A probably benign Het
Myo1f A T 17: 33,797,246 (GRCm39) I143L probably benign Het
Ncoa7 T A 10: 30,565,849 (GRCm39) E599D possibly damaging Het
Nfasc A T 1: 132,538,104 (GRCm39) C495* probably null Het
Nfx1 G A 4: 41,018,019 (GRCm39) G920E probably damaging Het
Nlrp4g T G 9: 124,348,980 (GRCm38) noncoding transcript Het
Nup85 T A 11: 115,468,757 (GRCm39) V200E probably damaging Het
Or2z2 T A 11: 58,345,906 (GRCm39) I290F probably damaging Het
Or5an1c T C 19: 12,218,120 (GRCm39) M302V probably benign Het
Pask T C 1: 93,238,606 (GRCm39) Q1293R possibly damaging Het
Ppfia2 T A 10: 106,636,646 (GRCm39) S232T probably benign Het
Prr12 G A 7: 44,695,612 (GRCm39) R1285W unknown Het
Rimoc1 C T 15: 4,015,848 (GRCm39) V239I probably benign Het
Rxylt1 A T 10: 121,930,548 (GRCm39) D126E probably damaging Het
Slc1a1 T A 19: 28,880,153 (GRCm39) F278I possibly damaging Het
Sos1 G T 17: 80,705,719 (GRCm39) T1284N probably damaging Het
Sp2 T A 11: 96,847,036 (GRCm39) Q475L probably damaging Het
Spmip2 C A 3: 79,356,741 (GRCm39) probably benign Het
Spmip2 C A 3: 79,356,742 (GRCm39) probably benign Het
Sspo A T 6: 48,444,917 (GRCm39) T2134S possibly damaging Het
Tbx1 C A 16: 18,401,552 (GRCm39) A300S probably benign Het
Uap1 A C 1: 169,994,281 (GRCm39) V65G probably benign Het
Ubr2 G A 17: 47,278,123 (GRCm39) T738I probably benign Het
Uvrag A T 7: 98,758,297 (GRCm39) Y81* probably null Het
Vmn2r116 T G 17: 23,603,907 (GRCm39) I44S probably benign Het
Xkr8 A T 4: 132,455,688 (GRCm39) Y228* probably null Het
Zbtb20 A G 16: 43,430,025 (GRCm39) I106V possibly damaging Het
Zc3h7a C T 16: 10,964,259 (GRCm39) S683N probably benign Het
Zfp146 A T 7: 29,861,905 (GRCm39) C46S possibly damaging Het
Zfp871 T C 17: 32,994,662 (GRCm39) E152G possibly damaging Het
Zfp90 T C 8: 107,146,156 (GRCm39) V57A probably damaging Het
Zhx3 A T 2: 160,621,718 (GRCm39) N816K probably damaging Het
Other mutations in Hspa12a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01419:Hspa12a APN 19 58,816,681 (GRCm39) splice site probably null
IGL01516:Hspa12a APN 19 58,816,108 (GRCm39) missense probably benign 0.00
IGL01766:Hspa12a APN 19 58,787,899 (GRCm39) missense probably damaging 0.99
IGL01986:Hspa12a APN 19 58,787,834 (GRCm39) missense probably benign 0.30
IGL02138:Hspa12a APN 19 58,816,730 (GRCm39) missense probably benign 0.45
IGL02576:Hspa12a APN 19 58,787,842 (GRCm39) missense possibly damaging 0.56
IGL02623:Hspa12a APN 19 58,797,983 (GRCm39) missense probably benign 0.01
IGL02890:Hspa12a APN 19 58,809,431 (GRCm39) critical splice donor site probably null
IGL03209:Hspa12a APN 19 58,810,493 (GRCm39) splice site probably null
IGL03343:Hspa12a APN 19 58,787,828 (GRCm39) missense probably benign 0.00
R0040:Hspa12a UTSW 19 58,788,056 (GRCm39) missense probably benign 0.10
R0090:Hspa12a UTSW 19 58,787,941 (GRCm39) missense probably benign 0.00
R2139:Hspa12a UTSW 19 58,787,914 (GRCm39) missense probably benign
R4031:Hspa12a UTSW 19 58,789,289 (GRCm39) missense probably benign 0.17
R4686:Hspa12a UTSW 19 58,788,181 (GRCm39) missense possibly damaging 0.90
R4914:Hspa12a UTSW 19 58,787,884 (GRCm39) missense probably damaging 1.00
R5046:Hspa12a UTSW 19 58,787,977 (GRCm39) missense probably damaging 1.00
R5580:Hspa12a UTSW 19 58,788,092 (GRCm39) missense probably benign 0.11
R5615:Hspa12a UTSW 19 58,793,082 (GRCm39) missense possibly damaging 0.56
R5781:Hspa12a UTSW 19 58,810,518 (GRCm39) missense probably damaging 0.99
R6777:Hspa12a UTSW 19 58,810,519 (GRCm39) missense probably benign 0.03
R6954:Hspa12a UTSW 19 58,788,124 (GRCm39) missense probably benign 0.05
R7038:Hspa12a UTSW 19 58,793,132 (GRCm39) missense probably damaging 1.00
R7151:Hspa12a UTSW 19 58,810,594 (GRCm39) missense probably benign 0.07
R7249:Hspa12a UTSW 19 58,793,865 (GRCm39) missense probably benign 0.27
R7677:Hspa12a UTSW 19 58,849,317 (GRCm39) missense probably benign 0.01
R8110:Hspa12a UTSW 19 58,809,445 (GRCm39) missense possibly damaging 0.86
R8830:Hspa12a UTSW 19 58,793,895 (GRCm39) missense possibly damaging 0.74
R8955:Hspa12a UTSW 19 58,788,058 (GRCm39) missense probably damaging 1.00
R8987:Hspa12a UTSW 19 58,787,903 (GRCm39) nonsense probably null
R9056:Hspa12a UTSW 19 58,813,720 (GRCm39) missense probably damaging 1.00
R9147:Hspa12a UTSW 19 58,793,890 (GRCm39) missense probably damaging 1.00
R9148:Hspa12a UTSW 19 58,793,890 (GRCm39) missense probably damaging 1.00
R9157:Hspa12a UTSW 19 58,789,292 (GRCm39) missense possibly damaging 0.86
R9316:Hspa12a UTSW 19 58,793,079 (GRCm39) missense probably benign 0.22
R9329:Hspa12a UTSW 19 58,789,298 (GRCm39) missense probably benign 0.01
R9370:Hspa12a UTSW 19 58,813,708 (GRCm39) missense probably damaging 1.00
R9486:Hspa12a UTSW 19 58,797,891 (GRCm39) missense probably benign 0.03
Posted On 2015-04-16