Incidental Mutation 'IGL02170:Zfp146'
ID 282890
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp146
Ensembl Gene ENSMUSG00000037029
Gene Name zinc finger protein 146
Synonyms OZF
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.186) question?
Stock # IGL02170
Quality Score
Status
Chromosome 7
Chromosomal Location 30161269-30169750 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 30162480 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 46 (C46S)
Ref Sequence ENSEMBL: ENSMUSP00000058588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062181]
AlphaFold Q8BQN6
Predicted Effect possibly damaging
Transcript: ENSMUST00000062181
AA Change: C46S

PolyPhen 2 Score 0.515 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000058588
Gene: ENSMUSG00000037029
AA Change: C46S

DomainStartEndE-ValueType
ZnF_C2H2 16 38 1.01e-1 SMART
ZnF_C2H2 44 66 5.5e-3 SMART
ZnF_C2H2 72 94 3.44e-4 SMART
ZnF_C2H2 100 122 2.27e-4 SMART
ZnF_C2H2 128 150 1.98e-4 SMART
ZnF_C2H2 156 178 3.89e-3 SMART
ZnF_C2H2 184 206 6.99e-5 SMART
ZnF_C2H2 212 234 1.6e-4 SMART
ZnF_C2H2 240 262 5.5e-3 SMART
ZnF_C2H2 268 290 1.82e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136508
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik G A 16: 17,118,332 P176L probably damaging Het
4932414N04Rik A G 2: 68,731,123 M265V probably benign Het
A2ml1 T C 6: 128,547,210 E1153G possibly damaging Het
Adam22 T C 5: 8,134,845 T452A probably benign Het
Ambra1 A G 2: 91,767,087 T56A possibly damaging Het
Atp1a4 A G 1: 172,234,536 V674A possibly damaging Het
AW549877 C T 15: 3,986,366 V239I probably benign Het
Ccnb1 A T 13: 100,783,486 Y172* probably null Het
Chrdl2 A T 7: 100,034,614 T416S possibly damaging Het
Col6a5 A G 9: 105,928,422 L1095P unknown Het
Dhx16 T C 17: 35,889,469 C901R probably damaging Het
Dip2c A G 13: 9,606,335 T732A probably benign Het
Dnah12 A C 14: 26,773,112 I1376L probably damaging Het
Dock2 A T 11: 34,267,949 L1207Q probably damaging Het
Eif2ak1 A T 5: 143,879,460 H192L probably benign Het
Evi5 T A 5: 107,821,884 T54S probably benign Het
Fam151a T C 4: 106,735,598 probably null Het
Fam98a C T 17: 75,540,192 probably null Het
Frmd4a G A 2: 4,566,177 R306K probably damaging Het
Fxyd7 C A 7: 31,045,007 V28L possibly damaging Het
Gabrb1 T A 5: 72,136,730 I449K probably damaging Het
Gkn3 G T 6: 87,383,511 D167E possibly damaging Het
Gm14496 A T 2: 181,996,351 Y406F probably damaging Het
Gm17359 C A 3: 79,449,434 probably benign Het
Gm17359 C A 3: 79,449,435 probably benign Het
Gm8603 T A 17: 13,516,811 noncoding transcript Het
Hecw1 T C 13: 14,264,158 N880S possibly damaging Het
Hivep2 C A 10: 14,127,804 Q49K possibly damaging Het
Hscb T A 5: 110,839,626 S35C probably damaging Het
Hspa12a T G 19: 58,804,681 K357N probably benign Het
Kcnu1 A T 8: 25,937,560 I302F probably damaging Het
Krtap5-3 T A 7: 142,202,478 C351S unknown Het
Mvd A G 8: 122,438,008 V142A probably benign Het
Myo1f A T 17: 33,578,272 I143L probably benign Het
Ncoa7 T A 10: 30,689,853 E599D possibly damaging Het
Nfasc A T 1: 132,610,366 C495* probably null Het
Nfx1 G A 4: 41,018,019 G920E probably damaging Het
Nlrp4g T G 9: 124,348,980 noncoding transcript Het
Nup85 T A 11: 115,577,931 V200E probably damaging Het
Olfr262 T C 19: 12,240,756 M302V probably benign Het
Olfr30 T A 11: 58,455,080 I290F probably damaging Het
Pask T C 1: 93,310,884 Q1293R possibly damaging Het
Ppfia2 T A 10: 106,800,785 S232T probably benign Het
Prr12 G A 7: 45,046,188 R1285W unknown Het
Slc1a1 T A 19: 28,902,753 F278I possibly damaging Het
Sos1 G T 17: 80,398,290 T1284N probably damaging Het
Sp2 T A 11: 96,956,210 Q475L probably damaging Het
Sspo A T 6: 48,467,983 T2134S possibly damaging Het
Tbx1 C A 16: 18,582,802 A300S probably benign Het
Tmem5 A T 10: 122,094,643 D126E probably damaging Het
Uap1 A C 1: 170,166,712 V65G probably benign Het
Ubr2 G A 17: 46,967,197 T738I probably benign Het
Uvrag A T 7: 99,109,090 Y81* probably null Het
Vmn2r116 T G 17: 23,384,933 I44S probably benign Het
Xkr8 A T 4: 132,728,377 Y228* probably null Het
Zbtb20 A G 16: 43,609,662 I106V possibly damaging Het
Zc3h7a C T 16: 11,146,395 S683N probably benign Het
Zfp871 T C 17: 32,775,688 E152G possibly damaging Het
Zfp90 T C 8: 106,419,524 V57A probably damaging Het
Zhx3 A T 2: 160,779,798 N816K probably damaging Het
Other mutations in Zfp146
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02485:Zfp146 APN 7 30162590 missense probably benign
IGL02796:Zfp146 UTSW 7 30162558 missense probably benign 0.01
R2043:Zfp146 UTSW 7 30162239 missense possibly damaging 0.92
R4166:Zfp146 UTSW 7 30162440 missense possibly damaging 0.50
R4385:Zfp146 UTSW 7 30162422 missense probably benign
R5270:Zfp146 UTSW 7 30162475 missense probably benign 0.03
R5271:Zfp146 UTSW 7 30162475 missense probably benign 0.03
R5746:Zfp146 UTSW 7 30162393 missense probably benign 0.00
Posted On 2015-04-16