Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02172:Vmn2r118'

282939

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL02172

Quality Score

Status

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 55624598 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 25 (M25I)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably benign
Transcript: ENSMUST00000168440
AA Change: M25I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: M25I

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 37,004,873	V3236A	probably damaging	Het
Abca12	A	G	1: 71,302,658	V1048A	probably benign	Het
Adgre1	C	T	17: 57,478,879	T875I	probably damaging	Het
Arhgef26	T	C	3: 62,459,676	V810A	probably benign	Het
Atf1	T	A	15: 100,254,441	V105E	probably damaging	Het
Bbs9	C	T	9: 22,579,476	T300I	possibly damaging	Het
Brd7	G	T	8: 88,351,824	H226Q	probably benign	Het
Cadps	T	C	14: 12,705,681	K238R	probably damaging	Het
Chordc1	A	G	9: 18,302,092	T80A	possibly damaging	Het
Clca4a	A	T	3: 144,970,394	C126*	probably null	Het
Col24a1	A	T	3: 145,314,962	T365S	probably benign	Het
Crb1	C	T	1: 139,237,227	G1053D	probably damaging	Het
Creb3l4	A	T	3: 90,242,775	S20T	probably benign	Het
Cyp2c67	C	T	19: 39,649,002	C10Y	possibly damaging	Het
Dhdh	A	T	7: 45,475,617	C294S	probably damaging	Het
Fam135a	A	G	1: 24,024,780		probably null	Het
Fsd1	G	T	17: 55,990,244		probably benign	Het
Gatad2b	A	G	3: 90,355,671		probably benign	Het
Glb1l2	T	C	9: 26,769,086	D232G	probably damaging	Het
Gm10553	T	C	1: 85,100,294	L44P	probably damaging	Het
Hecw1	T	C	13: 14,264,149	Y883C	probably damaging	Het
Helq	A	G	5: 100,790,147	F478L	probably damaging	Het
Ift172	T	C	5: 31,281,337		probably benign	Het
Krtcap3	A	C	5: 31,252,053	T55P	probably damaging	Het
Megf6	A	G	4: 154,270,692	D1488G	probably damaging	Het
Mrpl1	T	C	5: 96,231,715	V203A	probably damaging	Het
Myh2	A	T	11: 67,189,052	D1084V	possibly damaging	Het
Necap2	T	A	4: 141,078,310		probably benign	Het
Nemp1	A	G	10: 127,692,999	S191G	probably benign	Het
Nrip1	T	C	16: 76,291,492	D1059G	probably damaging	Het
Ntrk3	A	T	7: 78,460,272		probably benign	Het
Olfr558	G	A	7: 102,709,844	R195H	probably benign	Het
Olfr583	A	G	7: 103,051,375	I26V	probably benign	Het
Prkdc	T	G	16: 15,809,759	V3427G	probably benign	Het
Ptprn2	A	T	12: 116,873,697		probably benign	Het
Ptprt	A	T	2: 161,555,502	L1095H	probably damaging	Het
Ren1	T	A	1: 133,359,033	L300Q	possibly damaging	Het
Rgl3	A	G	9: 21,976,838	I460T	probably damaging	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Runx1t1	A	C	4: 13,859,924	Q265P	probably benign	Het
Sh3d21	A	G	4: 126,152,360	S282P	probably benign	Het
Slc39a13	T	C	2: 91,063,160	E318G	possibly damaging	Het
Srd5a3	T	C	5: 76,147,709	I82T	probably benign	Het
Stard7	C	A	2: 127,290,872	T220N	probably damaging	Het
Tbx4	G	A	11: 85,914,563	G493R	possibly damaging	Het
Trerf1	A	T	17: 47,317,817		noncoding transcript	Het
Trim59	T	A	3: 69,037,477	I177L	probably benign	Het
Trpm7	T	C	2: 126,795,328	M1789V	possibly damaging	Het
Tsc22d1	T	C	14: 76,417,692	V455A	probably benign	Het
Wdr38	A	T	2: 38,998,412	N7I	probably damaging	Het
Wdr90	G	A	17: 25,850,434	T1233I	probably benign	Het
Zcchc2	G	A	1: 106,000,934	D308N	probably benign	Het
Zfp57	G	T	17: 37,009,589	V112L	possibly damaging	Het
Zfp874b	A	T	13: 67,474,016	Y388N	probably damaging	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55592708	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55593204	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55593000	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55608585	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55592990	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55592619	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55610517	missense	probably benign	0.18
IGL02529:Vmn2r118	APN	17	55610870	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55592655	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55607996	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55608616	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55608643	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55611021	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55610970	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55610772	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55608466	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55608620	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55593237	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55610643	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55608083	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55611530	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55592456	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55610406	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55611556	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55592882	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55592925	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55624650	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55608421	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55610347	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55610665	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55610860	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55592581	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55592894	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55592765	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55593103	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55624494	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55592871	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55608093	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55592996	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55592714	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55592348	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55610440	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55592853	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55593242	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55608484	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55610936	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55610423	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55608057	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55608642	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55610216	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55610835	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55611649	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55610207	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55592837	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55611009	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55608415	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55593218	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55610655	nonsense	probably null

Posted On

2015-04-16