Incidental Mutation 'IGL02173:Olfr1502'
ID282972
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1502
Ensembl Gene ENSMUSG00000056858
Gene Nameolfactory receptor 1502
SynonymsGA_x6K02T2RE5P-4193992-4194942, MOR211-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock #IGL02173
Quality Score
Status
Chromosome19
Chromosomal Location13861795-13862745 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 13862014 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 74 (T74A)
Ref Sequence ENSEMBL: ENSMUSP00000073843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074221]
Predicted Effect probably benign
Transcript: ENSMUST00000074221
AA Change: T74A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000073843
Gene: ENSMUSG00000056858
AA Change: T74A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.1e-43 PFAM
Pfam:7tm_1 41 290 1.6e-17 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik A T 10: 87,225,892 H68L possibly damaging Het
4930533K18Rik A G 10: 70,872,230 noncoding transcript Het
4933409G03Rik A G 2: 68,613,057 T182A unknown Het
Abca2 T A 2: 25,441,897 D1340E probably benign Het
Abcc12 G A 8: 86,566,442 A39V probably damaging Het
Acap2 T C 16: 31,108,147 R510G possibly damaging Het
Ace G T 11: 105,988,991 R719L probably benign Het
Adarb1 A C 10: 77,321,825 F263V probably damaging Het
Ambra1 T C 2: 91,917,668 S1130P probably benign Het
Aqp7 A T 4: 41,034,379 L260* probably null Het
Cntn5 G T 9: 9,748,396 S493R probably damaging Het
Crhr2 A G 6: 55,103,180 F138S probably damaging Het
D2hgdh T A 1: 93,829,889 D175E probably benign Het
Dtx4 G T 19: 12,473,257 Y530* probably null Het
Elp4 T A 2: 105,702,743 H419L probably damaging Het
Etv6 A G 6: 134,248,727 D218G possibly damaging Het
Exoc5 A G 14: 49,034,801 probably benign Het
Fyb C T 15: 6,580,695 P250S probably benign Het
Gaa A G 11: 119,274,913 Y84C probably damaging Het
Galns A T 8: 122,598,626 S262R probably damaging Het
Gm4737 T C 16: 46,154,078 N312S probably benign Het
Kctd16 T C 18: 40,530,853 I345T probably benign Het
Lats2 A G 14: 57,697,260 V671A probably damaging Het
Maml3 C A 3: 51,690,787 L179F probably damaging Het
Myo1f T C 17: 33,607,344 L1089P probably damaging Het
Nadsyn1 A T 7: 143,804,006 probably benign Het
Olfr39 T C 9: 20,286,395 V240A probably benign Het
Olfr394 A G 11: 73,888,123 M83T possibly damaging Het
Olfr639 G A 7: 104,011,830 P291S probably damaging Het
Otog T C 7: 46,276,741 probably benign Het
Pcbd1 A G 10: 61,092,204 probably benign Het
Pced1a A G 2: 130,422,328 V164A possibly damaging Het
Pgd A G 4: 149,156,753 I233T probably damaging Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Sec24d A T 3: 123,353,681 H733L probably damaging Het
Slc1a2 T A 2: 102,743,861 N205K probably benign Het
Sstr2 G T 11: 113,625,016 V254L probably damaging Het
Tm9sf2 G T 14: 122,143,423 V308F probably benign Het
Tor3a T C 1: 156,674,206 K34E probably benign Het
Tsta3 A G 15: 75,926,185 S233P probably damaging Het
Ubr4 T A 4: 139,437,070 probably null Het
Vmn1r56 A G 7: 5,196,118 S167P probably damaging Het
Zswim3 T A 2: 164,820,839 I413N probably damaging Het
Other mutations in Olfr1502
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Olfr1502 APN 19 13861786 unclassified probably benign
IGL01061:Olfr1502 APN 19 13862705 missense possibly damaging 0.94
IGL01534:Olfr1502 APN 19 13861919 missense probably damaging 1.00
IGL02017:Olfr1502 APN 19 13862231 missense possibly damaging 0.58
IGL02039:Olfr1502 APN 19 13862719 nonsense probably null
IGL02219:Olfr1502 APN 19 13861823 missense probably damaging 1.00
IGL02475:Olfr1502 APN 19 13862299 missense probably damaging 1.00
IGL02604:Olfr1502 APN 19 13861806 missense probably benign 0.01
R0012:Olfr1502 UTSW 19 13861823 missense probably damaging 0.98
R0594:Olfr1502 UTSW 19 13862279 missense probably benign 0.04
R2184:Olfr1502 UTSW 19 13862035 missense probably benign 0.02
R2518:Olfr1502 UTSW 19 13862309 missense probably damaging 1.00
R5541:Olfr1502 UTSW 19 13861964 missense probably benign
R5587:Olfr1502 UTSW 19 13862576 missense probably damaging 1.00
R6211:Olfr1502 UTSW 19 13862574 missense probably benign 0.01
R6351:Olfr1502 UTSW 19 13861822 missense probably benign 0.04
R7575:Olfr1502 UTSW 19 13862017 missense probably damaging 1.00
Posted On2015-04-16