Incidental Mutation 'IGL02173:Zswim3'
ID282991
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zswim3
Ensembl Gene ENSMUSG00000045822
Gene Namezinc finger SWIM-type containing 3
Synonyms4921517A06Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #IGL02173
Quality Score
Status
Chromosome2
Chromosomal Location164805098-164822130 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 164820839 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 413 (I413N)
Ref Sequence ENSEMBL: ENSMUSP00000050970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017908] [ENSMUST00000052107] [ENSMUST00000132282]
Predicted Effect probably benign
Transcript: ENSMUST00000017908
SMART Domains Protein: ENSMUSP00000017908
Gene: ENSMUSG00000017764

DomainStartEndE-ValueType
Pfam:SWIM 342 375 2e-9 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000052107
AA Change: I413N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000050970
Gene: ENSMUSG00000045822
AA Change: I413N

DomainStartEndE-ValueType
low complexity region 436 453 N/A INTRINSIC
low complexity region 474 489 N/A INTRINSIC
ZnF_PMZ 546 573 2.09e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132282
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik A T 10: 87,225,892 H68L possibly damaging Het
4930533K18Rik A G 10: 70,872,230 noncoding transcript Het
4933409G03Rik A G 2: 68,613,057 T182A unknown Het
Abca2 T A 2: 25,441,897 D1340E probably benign Het
Abcc12 G A 8: 86,566,442 A39V probably damaging Het
Acap2 T C 16: 31,108,147 R510G possibly damaging Het
Ace G T 11: 105,988,991 R719L probably benign Het
Adarb1 A C 10: 77,321,825 F263V probably damaging Het
Ambra1 T C 2: 91,917,668 S1130P probably benign Het
Aqp7 A T 4: 41,034,379 L260* probably null Het
Cntn5 G T 9: 9,748,396 S493R probably damaging Het
Crhr2 A G 6: 55,103,180 F138S probably damaging Het
D2hgdh T A 1: 93,829,889 D175E probably benign Het
Dtx4 G T 19: 12,473,257 Y530* probably null Het
Elp4 T A 2: 105,702,743 H419L probably damaging Het
Etv6 A G 6: 134,248,727 D218G possibly damaging Het
Exoc5 A G 14: 49,034,801 probably benign Het
Fyb C T 15: 6,580,695 P250S probably benign Het
Gaa A G 11: 119,274,913 Y84C probably damaging Het
Galns A T 8: 122,598,626 S262R probably damaging Het
Gm4737 T C 16: 46,154,078 N312S probably benign Het
Kctd16 T C 18: 40,530,853 I345T probably benign Het
Lats2 A G 14: 57,697,260 V671A probably damaging Het
Maml3 C A 3: 51,690,787 L179F probably damaging Het
Myo1f T C 17: 33,607,344 L1089P probably damaging Het
Nadsyn1 A T 7: 143,804,006 probably benign Het
Olfr1502 A G 19: 13,862,014 T74A probably benign Het
Olfr39 T C 9: 20,286,395 V240A probably benign Het
Olfr394 A G 11: 73,888,123 M83T possibly damaging Het
Olfr639 G A 7: 104,011,830 P291S probably damaging Het
Otog T C 7: 46,276,741 probably benign Het
Pcbd1 A G 10: 61,092,204 probably benign Het
Pced1a A G 2: 130,422,328 V164A possibly damaging Het
Pgd A G 4: 149,156,753 I233T probably damaging Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Sec24d A T 3: 123,353,681 H733L probably damaging Het
Slc1a2 T A 2: 102,743,861 N205K probably benign Het
Sstr2 G T 11: 113,625,016 V254L probably damaging Het
Tm9sf2 G T 14: 122,143,423 V308F probably benign Het
Tor3a T C 1: 156,674,206 K34E probably benign Het
Tsta3 A G 15: 75,926,185 S233P probably damaging Het
Ubr4 T A 4: 139,437,070 probably null Het
Vmn1r56 A G 7: 5,196,118 S167P probably damaging Het
Other mutations in Zswim3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Zswim3 APN 2 164821091 missense probably damaging 1.00
IGL01345:Zswim3 APN 2 164820137 missense probably damaging 1.00
IGL01608:Zswim3 APN 2 164821520 missense probably damaging 1.00
IGL01621:Zswim3 APN 2 164821520 missense probably damaging 1.00
IGL01634:Zswim3 APN 2 164820002 missense probably damaging 0.99
IGL02165:Zswim3 APN 2 164821115 missense possibly damaging 0.94
IGL02336:Zswim3 APN 2 164820377 missense probably damaging 0.98
IGL02379:Zswim3 APN 2 164820682 splice site probably null
R0321:Zswim3 UTSW 2 164820359 missense possibly damaging 0.83
R1489:Zswim3 UTSW 2 164819981 missense probably benign 0.00
R2126:Zswim3 UTSW 2 164819993 missense probably benign 0.31
R2176:Zswim3 UTSW 2 164820694 missense probably benign 0.08
R2859:Zswim3 UTSW 2 164820389 missense probably damaging 1.00
R3853:Zswim3 UTSW 2 164820857 missense possibly damaging 0.61
R4434:Zswim3 UTSW 2 164820643 missense probably benign 0.00
R4435:Zswim3 UTSW 2 164820643 missense probably benign 0.00
R4436:Zswim3 UTSW 2 164820643 missense probably benign 0.00
R4438:Zswim3 UTSW 2 164820643 missense probably benign 0.00
R4805:Zswim3 UTSW 2 164820179 missense possibly damaging 0.52
R5874:Zswim3 UTSW 2 164820112 missense probably benign 0.06
R6417:Zswim3 UTSW 2 164820733 missense probably damaging 0.97
R6420:Zswim3 UTSW 2 164820733 missense probably damaging 0.97
R6722:Zswim3 UTSW 2 164820624 splice site probably null
R6786:Zswim3 UTSW 2 164820851 missense probably damaging 1.00
R7266:Zswim3 UTSW 2 164820482 missense probably benign 0.41
R7467:Zswim3 UTSW 2 164819875 missense possibly damaging 0.59
R7487:Zswim3 UTSW 2 164820215 missense probably damaging 0.99
R7788:Zswim3 UTSW 2 164819779 missense probably damaging 1.00
R8191:Zswim3 UTSW 2 164820208 missense probably damaging 1.00
R8308:Zswim3 UTSW 2 164821646 missense probably damaging 1.00
Posted On2015-04-16