Incidental Mutation 'IGL02173:Kctd16'
ID282998
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kctd16
Ensembl Gene ENSMUSG00000051401
Gene Namepotassium channel tetramerisation domain containing 16
Synonyms4930434H12Rik, LOC383347
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.157) question?
Stock #IGL02173
Quality Score
Status
Chromosome18
Chromosomal Location40258361-40531168 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 40530853 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 345 (I345T)
Ref Sequence ENSEMBL: ENSMUSP00000089547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091927]
Predicted Effect probably benign
Transcript: ENSMUST00000091927
AA Change: I345T

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000089547
Gene: ENSMUSG00000051401
AA Change: I345T

DomainStartEndE-ValueType
BTB 25 130 8.7e-7 SMART
low complexity region 288 300 N/A INTRINSIC
low complexity region 374 396 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout leads to reduced extinction or increase of fear memory in cued or contextual conditioning behavior tests, respectively. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik A T 10: 87,225,892 H68L possibly damaging Het
4930533K18Rik A G 10: 70,872,230 noncoding transcript Het
4933409G03Rik A G 2: 68,613,057 T182A unknown Het
Abca2 T A 2: 25,441,897 D1340E probably benign Het
Abcc12 G A 8: 86,566,442 A39V probably damaging Het
Acap2 T C 16: 31,108,147 R510G possibly damaging Het
Ace G T 11: 105,988,991 R719L probably benign Het
Adarb1 A C 10: 77,321,825 F263V probably damaging Het
Ambra1 T C 2: 91,917,668 S1130P probably benign Het
Aqp7 A T 4: 41,034,379 L260* probably null Het
Cntn5 G T 9: 9,748,396 S493R probably damaging Het
Crhr2 A G 6: 55,103,180 F138S probably damaging Het
D2hgdh T A 1: 93,829,889 D175E probably benign Het
Dtx4 G T 19: 12,473,257 Y530* probably null Het
Elp4 T A 2: 105,702,743 H419L probably damaging Het
Etv6 A G 6: 134,248,727 D218G possibly damaging Het
Exoc5 A G 14: 49,034,801 probably benign Het
Fyb C T 15: 6,580,695 P250S probably benign Het
Gaa A G 11: 119,274,913 Y84C probably damaging Het
Galns A T 8: 122,598,626 S262R probably damaging Het
Gm4737 T C 16: 46,154,078 N312S probably benign Het
Lats2 A G 14: 57,697,260 V671A probably damaging Het
Maml3 C A 3: 51,690,787 L179F probably damaging Het
Myo1f T C 17: 33,607,344 L1089P probably damaging Het
Nadsyn1 A T 7: 143,804,006 probably benign Het
Olfr1502 A G 19: 13,862,014 T74A probably benign Het
Olfr39 T C 9: 20,286,395 V240A probably benign Het
Olfr394 A G 11: 73,888,123 M83T possibly damaging Het
Olfr639 G A 7: 104,011,830 P291S probably damaging Het
Otog T C 7: 46,276,741 probably benign Het
Pcbd1 A G 10: 61,092,204 probably benign Het
Pced1a A G 2: 130,422,328 V164A possibly damaging Het
Pgd A G 4: 149,156,753 I233T probably damaging Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Sec24d A T 3: 123,353,681 H733L probably damaging Het
Slc1a2 T A 2: 102,743,861 N205K probably benign Het
Sstr2 G T 11: 113,625,016 V254L probably damaging Het
Tm9sf2 G T 14: 122,143,423 V308F probably benign Het
Tor3a T C 1: 156,674,206 K34E probably benign Het
Tsta3 A G 15: 75,926,185 S233P probably damaging Het
Ubr4 T A 4: 139,437,070 probably null Het
Vmn1r56 A G 7: 5,196,118 S167P probably damaging Het
Zswim3 T A 2: 164,820,839 I413N probably damaging Het
Other mutations in Kctd16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00954:Kctd16 APN 18 40258800 missense probably benign 0.01
IGL02001:Kctd16 APN 18 40258680 missense possibly damaging 0.48
IGL03112:Kctd16 APN 18 40258800 missense probably benign 0.08
R0109:Kctd16 UTSW 18 40259151 missense probably benign 0.06
R0109:Kctd16 UTSW 18 40259151 missense probably benign 0.06
R0267:Kctd16 UTSW 18 40530877 missense probably benign 0.02
R0554:Kctd16 UTSW 18 40258439 missense probably benign
R0732:Kctd16 UTSW 18 40258563 missense probably damaging 1.00
R0883:Kctd16 UTSW 18 40530775 missense probably damaging 0.98
R2140:Kctd16 UTSW 18 40259178 missense possibly damaging 0.89
R2141:Kctd16 UTSW 18 40259178 missense possibly damaging 0.89
R2142:Kctd16 UTSW 18 40259178 missense possibly damaging 0.89
R2160:Kctd16 UTSW 18 40259085 missense probably damaging 1.00
R3723:Kctd16 UTSW 18 40258859 missense possibly damaging 0.79
R3724:Kctd16 UTSW 18 40258859 missense possibly damaging 0.79
R5483:Kctd16 UTSW 18 40530876 missense probably benign
R5589:Kctd16 UTSW 18 40259008 missense probably damaging 1.00
R5767:Kctd16 UTSW 18 40258869 missense probably benign 0.13
R5811:Kctd16 UTSW 18 40258452 missense probably damaging 1.00
R5911:Kctd16 UTSW 18 40530852 missense probably benign 0.11
R5930:Kctd16 UTSW 18 40530829 missense probably benign 0.10
R6017:Kctd16 UTSW 18 40258943 missense probably damaging 1.00
R6603:Kctd16 UTSW 18 40258491 missense probably benign
R7404:Kctd16 UTSW 18 40258773 missense probably damaging 1.00
R7597:Kctd16 UTSW 18 40530795 missense possibly damaging 0.70
Posted On2015-04-16