Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02174:Or8b41'

283006

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8b41

Ensembl Gene

ENSMUSG00000096409

Gene Name

olfactory receptor family 8 subfamily B member 41

Synonyms

Olfr890, MOR162-15_p, MOR162-3, GA_x6K02T2PVTD-31822365-31823309

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02174

Quality Score

Status

Chromosome

Chromosomal Location

38054433-38055377 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 38055081 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 217 (T217S)

Ref Sequence

ENSEMBL: ENSMUSP00000078733 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079804] [ENSMUST00000213087] [ENSMUST00000213458]

AlphaFold

Q7TRD9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079804
AA Change: T217S

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000078733
Gene: ENSMUSG00000096409
AA Change: T217S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	36	311	2.3e-48	PFAM
Pfam:7tm_1	46	293	9.6e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213087
AA Change: T212S

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213458
AA Change: T212S

PolyPhen 2 Score 0.797 (Sensitivity: 0.84; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	T	C	14: 118,738,154 (GRCm39)	I1199V	probably damaging	Het
Adgrv1	G	A	13: 81,575,783 (GRCm39)	T4861I	probably benign	Het
Ampd2	T	C	3: 107,987,601 (GRCm39)	D108G	probably damaging	Het
Azin1	A	G	15: 38,493,730 (GRCm39)	F298L	probably benign	Het
Bag1	T	A	4: 40,941,555 (GRCm39)	E123D	possibly damaging	Het
Cabs1	A	G	5: 88,128,339 (GRCm39)	E330G	probably benign	Het
Ccdc33	T	C	9: 57,940,938 (GRCm39)	K435E	probably benign	Het
Clip2	T	G	5: 134,523,118 (GRCm39)	K943T	probably damaging	Het
Cmya5	T	C	13: 93,185,415 (GRCm39)	I3527V	possibly damaging	Het
Cyp2w1	C	T	5: 139,341,384 (GRCm39)	R244C	probably benign	Het
Dcaf13	C	A	15: 39,001,544 (GRCm39)	A284E	probably damaging	Het
Ddx31	T	A	2: 28,749,041 (GRCm39)	L279Q	probably damaging	Het
Dgki	A	G	6: 37,009,856 (GRCm39)	L497P	probably damaging	Het
Dnah12	A	T	14: 26,428,072 (GRCm39)	I233F	probably benign	Het
Dpp6	G	T	5: 27,926,085 (GRCm39)	G720*	probably null	Het
Emc1	T	C	4: 139,098,979 (GRCm39)	Y821H	possibly damaging	Het
Esr1	C	T	10: 4,948,003 (GRCm39)	R519W	probably damaging	Het
Gamt	A	T	10: 80,094,230 (GRCm39)	V227E	possibly damaging	Het
Habp2	A	G	19: 56,300,169 (GRCm39)	Q206R	probably damaging	Het
Ihh	A	G	1: 74,990,105 (GRCm39)	I90T	probably damaging	Het
Kif20b	T	C	19: 34,911,858 (GRCm39)		probably benign	Het
Lcp2	T	C	11: 34,000,966 (GRCm39)		probably benign	Het
Lyrm2	A	G	4: 32,800,649 (GRCm39)	I29V	probably benign	Het
Macf1	T	C	4: 123,385,587 (GRCm39)	D1168G	probably damaging	Het
Mocos	T	C	18: 24,828,953 (GRCm39)	S753P	probably benign	Het
Myo3a	A	G	2: 22,337,204 (GRCm39)	E367G	probably benign	Het
Ndor1	G	A	2: 25,139,206 (GRCm39)	A255V	possibly damaging	Het
Nfat5	C	T	8: 108,065,683 (GRCm39)	P148S	probably damaging	Het
Or4c121	A	T	2: 89,023,712 (GRCm39)	F222Y	probably benign	Het
Or5al7	T	A	2: 85,992,442 (GRCm39)	M284L	possibly damaging	Het
Or6z7	T	C	7: 6,483,438 (GRCm39)	Y239C	probably benign	Het
Pappa2	C	T	1: 158,589,188 (GRCm39)	C1679Y	probably damaging	Het
Pcdhb2	T	A	18: 37,429,551 (GRCm39)	I508N	probably damaging	Het
Pkd2l1	G	A	19: 44,145,707 (GRCm39)	T172I	probably benign	Het
Pld5	A	G	1: 176,102,310 (GRCm39)	V44A	possibly damaging	Het
Prss44	T	C	9: 110,646,199 (GRCm39)	W309R	probably damaging	Het
Rc3h2	A	T	2: 37,301,237 (GRCm39)	N88K	probably benign	Het
Rspry1	A	G	8: 95,359,768 (GRCm39)	I102M	possibly damaging	Het
Stab2	A	G	10: 86,695,606 (GRCm39)		probably null	Het
Tbx3	C	A	5: 119,813,649 (GRCm39)	Y228*	probably null	Het
Tcf15	G	T	2: 151,986,065 (GRCm39)		probably benign	Het
Tmem41b	A	G	7: 109,578,003 (GRCm39)	S94P	possibly damaging	Het
Trmt10b	A	T	4: 45,308,508 (GRCm39)	I223F	possibly damaging	Het
Tyrp1	G	T	4: 80,763,063 (GRCm39)	G317*	probably null	Het
Urod	T	A	4: 116,847,479 (GRCm39)		probably benign	Het
Vwf	G	T	6: 125,532,358 (GRCm39)	R52L	probably damaging	Het
Wnk2	C	A	13: 49,210,643 (GRCm39)	Q232H	probably damaging	Het
Zbtb10	C	A	3: 9,316,872 (GRCm39)	P228Q	probably damaging	Het
Zfp764l1	G	A	7: 126,991,525 (GRCm39)	T154I	possibly damaging	Het

Other mutations in Or8b41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01505:Or8b41	APN	9	38,055,167 (GRCm39)	nonsense	probably null
IGL01861:Or8b41	APN	9	38,055,046 (GRCm39)	missense	probably damaging	1.00
IGL02723:Or8b41	APN	9	38,054,707 (GRCm39)	missense	probably benign	0.02
IGL03085:Or8b41	APN	9	38,054,479 (GRCm39)	missense	probably damaging	0.98
FR4449:Or8b41	UTSW	9	38,054,484 (GRCm39)	missense	probably benign	0.00
FR4737:Or8b41	UTSW	9	38,054,484 (GRCm39)	missense	probably benign	0.00
R0637:Or8b41	UTSW	9	38,055,178 (GRCm39)	missense	probably benign	0.00
R1353:Or8b41	UTSW	9	38,055,024 (GRCm39)	missense	probably benign	0.03
R1813:Or8b41	UTSW	9	38,055,025 (GRCm39)	missense	possibly damaging	0.78
R5997:Or8b41	UTSW	9	38,055,097 (GRCm39)	missense	probably damaging	1.00
R6004:Or8b41	UTSW	9	38,055,256 (GRCm39)	missense	probably damaging	1.00
R6417:Or8b41	UTSW	9	38,054,611 (GRCm39)	missense	probably damaging	1.00
R6420:Or8b41	UTSW	9	38,054,611 (GRCm39)	missense	probably damaging	1.00
R6720:Or8b41	UTSW	9	38,054,449 (GRCm39)	start codon destroyed	probably null	1.00
R7223:Or8b41	UTSW	9	38,055,049 (GRCm39)	missense	probably benign	0.02
R7601:Or8b41	UTSW	9	38,054,674 (GRCm39)	missense	probably benign	0.13
R7671:Or8b41	UTSW	9	38,054,736 (GRCm39)	missense	probably benign	0.02
R8034:Or8b41	UTSW	9	38,054,973 (GRCm39)	missense	probably damaging	1.00
R8356:Or8b41	UTSW	9	38,054,981 (GRCm39)	nonsense	probably null
R8456:Or8b41	UTSW	9	38,054,981 (GRCm39)	nonsense	probably null
R8696:Or8b41	UTSW	9	38,054,433 (GRCm39)	start codon destroyed	probably null	0.00
R9487:Or8b41	UTSW	9	38,054,866 (GRCm39)	missense	probably benign	0.22
R9517:Or8b41	UTSW	9	38,054,623 (GRCm39)	missense	probably damaging	1.00
Z1176:Or8b41	UTSW	9	38,054,727 (GRCm39)	missense	probably benign	0.02

Posted On

2015-04-16