Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02174:Dcaf13'

283036

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dcaf13

Ensembl Gene

ENSMUSG00000022300

Gene Name

DDB1 and CUL4 associated factor 13

Synonyms

Wdsof1, LOC223499

Accession Numbers

Essential gene?

Probably essential (E-score: 0.955) question?

Stock #

IGL02174

Quality Score

Status

Chromosome

Chromosomal Location

38976300-39010251 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 39001544 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Glutamic Acid at position 284 (A284E)

Ref Sequence

ENSEMBL: ENSMUSP00000022909 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022909]

AlphaFold

Q6PAC3

Predicted Effect

probably damaging
Transcript: ENSMUST00000022909
AA Change: A284E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: A284E

Domain	Start	End	E-Value	Type
WD40	55	95	5.77e-5	SMART
WD40	98	137	4.38e-5	SMART
WD40	185	225	5.97e-1	SMART
Blast:WD40	228	267	1e-18	BLAST
WD40	271	310	2.69e-5	SMART
WD40	312	353	2.96e-2	SMART
Pfam:Sof1	354	440	7.2e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226224

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	T	C	14: 118,738,154 (GRCm39)	I1199V	probably damaging	Het
Adgrv1	G	A	13: 81,575,783 (GRCm39)	T4861I	probably benign	Het
Ampd2	T	C	3: 107,987,601 (GRCm39)	D108G	probably damaging	Het
Azin1	A	G	15: 38,493,730 (GRCm39)	F298L	probably benign	Het
Bag1	T	A	4: 40,941,555 (GRCm39)	E123D	possibly damaging	Het
Cabs1	A	G	5: 88,128,339 (GRCm39)	E330G	probably benign	Het
Ccdc33	T	C	9: 57,940,938 (GRCm39)	K435E	probably benign	Het
Clip2	T	G	5: 134,523,118 (GRCm39)	K943T	probably damaging	Het
Cmya5	T	C	13: 93,185,415 (GRCm39)	I3527V	possibly damaging	Het
Cyp2w1	C	T	5: 139,341,384 (GRCm39)	R244C	probably benign	Het
Ddx31	T	A	2: 28,749,041 (GRCm39)	L279Q	probably damaging	Het
Dgki	A	G	6: 37,009,856 (GRCm39)	L497P	probably damaging	Het
Dnah12	A	T	14: 26,428,072 (GRCm39)	I233F	probably benign	Het
Dpp6	G	T	5: 27,926,085 (GRCm39)	G720*	probably null	Het
Emc1	T	C	4: 139,098,979 (GRCm39)	Y821H	possibly damaging	Het
Esr1	C	T	10: 4,948,003 (GRCm39)	R519W	probably damaging	Het
Gamt	A	T	10: 80,094,230 (GRCm39)	V227E	possibly damaging	Het
Habp2	A	G	19: 56,300,169 (GRCm39)	Q206R	probably damaging	Het
Ihh	A	G	1: 74,990,105 (GRCm39)	I90T	probably damaging	Het
Kif20b	T	C	19: 34,911,858 (GRCm39)		probably benign	Het
Lcp2	T	C	11: 34,000,966 (GRCm39)		probably benign	Het
Lyrm2	A	G	4: 32,800,649 (GRCm39)	I29V	probably benign	Het
Macf1	T	C	4: 123,385,587 (GRCm39)	D1168G	probably damaging	Het
Mocos	T	C	18: 24,828,953 (GRCm39)	S753P	probably benign	Het
Myo3a	A	G	2: 22,337,204 (GRCm39)	E367G	probably benign	Het
Ndor1	G	A	2: 25,139,206 (GRCm39)	A255V	possibly damaging	Het
Nfat5	C	T	8: 108,065,683 (GRCm39)	P148S	probably damaging	Het
Or4c121	A	T	2: 89,023,712 (GRCm39)	F222Y	probably benign	Het
Or5al7	T	A	2: 85,992,442 (GRCm39)	M284L	possibly damaging	Het
Or6z7	T	C	7: 6,483,438 (GRCm39)	Y239C	probably benign	Het
Or8b41	A	T	9: 38,055,081 (GRCm39)	T217S	possibly damaging	Het
Pappa2	C	T	1: 158,589,188 (GRCm39)	C1679Y	probably damaging	Het
Pcdhb2	T	A	18: 37,429,551 (GRCm39)	I508N	probably damaging	Het
Pkd2l1	G	A	19: 44,145,707 (GRCm39)	T172I	probably benign	Het
Pld5	A	G	1: 176,102,310 (GRCm39)	V44A	possibly damaging	Het
Prss44	T	C	9: 110,646,199 (GRCm39)	W309R	probably damaging	Het
Rc3h2	A	T	2: 37,301,237 (GRCm39)	N88K	probably benign	Het
Rspry1	A	G	8: 95,359,768 (GRCm39)	I102M	possibly damaging	Het
Stab2	A	G	10: 86,695,606 (GRCm39)		probably null	Het
Tbx3	C	A	5: 119,813,649 (GRCm39)	Y228*	probably null	Het
Tcf15	G	T	2: 151,986,065 (GRCm39)		probably benign	Het
Tmem41b	A	G	7: 109,578,003 (GRCm39)	S94P	possibly damaging	Het
Trmt10b	A	T	4: 45,308,508 (GRCm39)	I223F	possibly damaging	Het
Tyrp1	G	T	4: 80,763,063 (GRCm39)	G317*	probably null	Het
Urod	T	A	4: 116,847,479 (GRCm39)		probably benign	Het
Vwf	G	T	6: 125,532,358 (GRCm39)	R52L	probably damaging	Het
Wnk2	C	A	13: 49,210,643 (GRCm39)	Q232H	probably damaging	Het
Zbtb10	C	A	3: 9,316,872 (GRCm39)	P228Q	probably damaging	Het
Zfp764l1	G	A	7: 126,991,525 (GRCm39)	T154I	possibly damaging	Het

Other mutations in Dcaf13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00787:Dcaf13	APN	15	39,007,027 (GRCm39)	nonsense	probably null
IGL01081:Dcaf13	APN	15	38,982,201 (GRCm39)	missense	probably damaging	1.00
IGL01766:Dcaf13	APN	15	38,982,145 (GRCm39)	missense	probably benign	0.00
IGL02262:Dcaf13	APN	15	38,982,102 (GRCm39)	splice site	probably benign
IGL02740:Dcaf13	APN	15	39,008,495 (GRCm39)	nonsense	probably null
IGL03092:Dcaf13	APN	15	38,991,371 (GRCm39)	splice site	probably benign
IGL03374:Dcaf13	APN	15	39,008,543 (GRCm39)	nonsense	probably null
R0590:Dcaf13	UTSW	15	39,008,480 (GRCm39)	splice site	probably benign
R0594:Dcaf13	UTSW	15	38,986,663 (GRCm39)	missense	probably benign	0.00
R0711:Dcaf13	UTSW	15	39,001,484 (GRCm39)	missense	probably damaging	1.00
R1036:Dcaf13	UTSW	15	39,007,113 (GRCm39)	missense	probably damaging	1.00
R1770:Dcaf13	UTSW	15	38,993,633 (GRCm39)	missense	probably damaging	1.00
R1826:Dcaf13	UTSW	15	38,982,294 (GRCm39)	missense	probably damaging	1.00
R1933:Dcaf13	UTSW	15	39,001,483 (GRCm39)	missense	probably damaging	0.99
R2508:Dcaf13	UTSW	15	39,008,547 (GRCm39)	missense	probably benign
R4113:Dcaf13	UTSW	15	38,993,615 (GRCm39)	missense	probably damaging	0.98
R4595:Dcaf13	UTSW	15	38,982,288 (GRCm39)	missense	probably damaging	1.00
R4649:Dcaf13	UTSW	15	39,001,637 (GRCm39)	missense	possibly damaging	0.54
R5431:Dcaf13	UTSW	15	38,986,619 (GRCm39)	missense	probably benign	0.16
R5454:Dcaf13	UTSW	15	38,987,759 (GRCm39)	missense	probably benign
R5834:Dcaf13	UTSW	15	39,007,037 (GRCm39)	nonsense	probably null
R5929:Dcaf13	UTSW	15	39,007,048 (GRCm39)	missense	possibly damaging	0.89
R5944:Dcaf13	UTSW	15	39,010,072 (GRCm39)	missense	probably benign
R6319:Dcaf13	UTSW	15	39,007,067 (GRCm39)	missense	probably benign	0.00
R6394:Dcaf13	UTSW	15	39,007,132 (GRCm39)	missense	probably benign	0.04
R6664:Dcaf13	UTSW	15	38,982,283 (GRCm39)	missense	probably damaging	1.00
R6884:Dcaf13	UTSW	15	38,986,635 (GRCm39)	missense	probably damaging	1.00
R7419:Dcaf13	UTSW	15	38,993,615 (GRCm39)	missense	probably damaging	0.98
R8750:Dcaf13	UTSW	15	38,982,836 (GRCm39)	missense	probably damaging	1.00
R8944:Dcaf13	UTSW	15	39,001,612 (GRCm39)	missense	possibly damaging	0.79
R9294:Dcaf13	UTSW	15	38,993,687 (GRCm39)	missense	possibly damaging	0.92
R9300:Dcaf13	UTSW	15	39,010,102 (GRCm39)	missense	probably damaging	1.00
R9663:Dcaf13	UTSW	15	38,982,178 (GRCm39)	missense	possibly damaging	0.88
R9696:Dcaf13	UTSW	15	39,001,496 (GRCm39)	missense	possibly damaging	0.80
R9778:Dcaf13	UTSW	15	39,008,586 (GRCm39)	missense	probably damaging	0.99
Z1088:Dcaf13	UTSW	15	39,008,642 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16