Incidental Mutation 'IGL02174:Dcaf13'
ID283036
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcaf13
Ensembl Gene ENSMUSG00000022300
Gene NameDDB1 and CUL4 associated factor 13
SynonymsLOC223499, Wdsof1
Accession Numbers

Genbank: NM_198606; MGI: 2684929

Is this an essential gene? Probably essential (E-score: 0.955) question?
Stock #IGL02174
Quality Score
Status
Chromosome15
Chromosomal Location39112865-39146856 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 39138149 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Glutamic Acid at position 284 (A284E)
Ref Sequence ENSEMBL: ENSMUSP00000022909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022909]
Predicted Effect probably damaging
Transcript: ENSMUST00000022909
AA Change: A284E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: A284E

DomainStartEndE-ValueType
WD40 55 95 5.77e-5 SMART
WD40 98 137 4.38e-5 SMART
WD40 185 225 5.97e-1 SMART
Blast:WD40 228 267 1e-18 BLAST
WD40 271 310 2.69e-5 SMART
WD40 312 353 2.96e-2 SMART
Pfam:Sof1 354 440 7.2e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226224
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 T C 14: 118,500,742 I1199V probably damaging Het
Adgrv1 G A 13: 81,427,664 T4861I probably benign Het
Ampd2 T C 3: 108,080,285 D108G probably damaging Het
Azin1 A G 15: 38,493,486 F298L probably benign Het
Bag1 T A 4: 40,941,555 E123D possibly damaging Het
Cabs1 A G 5: 87,980,480 E330G probably benign Het
Ccdc33 T C 9: 58,033,655 K435E probably benign Het
Clip2 T G 5: 134,494,264 K943T probably damaging Het
Cmya5 T C 13: 93,048,907 I3527V possibly damaging Het
Cyp2w1 C T 5: 139,355,629 R244C probably benign Het
Ddx31 T A 2: 28,859,029 L279Q probably damaging Het
Dgki A G 6: 37,032,921 L497P probably damaging Het
Dnah12 A T 14: 26,706,917 I233F probably benign Het
Dpp6 G T 5: 27,721,087 G720* probably null Het
E430018J23Rik G A 7: 127,392,353 T154I possibly damaging Het
Emc1 T C 4: 139,371,668 Y821H possibly damaging Het
Esr1 C T 10: 4,998,003 R519W probably damaging Het
Gamt A T 10: 80,258,396 V227E possibly damaging Het
Habp2 A G 19: 56,311,737 Q206R probably damaging Het
Ihh A G 1: 74,950,946 I90T probably damaging Het
Kif20b T C 19: 34,934,458 probably benign Het
Lcp2 T C 11: 34,050,966 probably benign Het
Lyrm2 A G 4: 32,800,649 I29V probably benign Het
Macf1 T C 4: 123,491,794 D1168G probably damaging Het
Mocos T C 18: 24,695,896 S753P probably benign Het
Myo3a A G 2: 22,332,393 E367G probably benign Het
Ndor1 G A 2: 25,249,194 A255V possibly damaging Het
Nfat5 C T 8: 107,339,051 P148S probably damaging Het
Olfr1043 T A 2: 86,162,098 M284L possibly damaging Het
Olfr1226 A T 2: 89,193,368 F222Y probably benign Het
Olfr5 T C 7: 6,480,439 Y239C probably benign Het
Olfr890 A T 9: 38,143,785 T217S possibly damaging Het
Pappa2 C T 1: 158,761,618 C1679Y probably damaging Het
Pcdhb2 T A 18: 37,296,498 I508N probably damaging Het
Pkd2l1 G A 19: 44,157,268 T172I probably benign Het
Pld5 A G 1: 176,274,744 V44A possibly damaging Het
Prss44 T C 9: 110,817,131 W309R probably damaging Het
Rc3h2 A T 2: 37,411,225 N88K probably benign Het
Rspry1 A G 8: 94,633,140 I102M possibly damaging Het
Stab2 A G 10: 86,859,742 probably null Het
Tbx3 C A 5: 119,675,584 Y228* probably null Het
Tcf15 G T 2: 152,144,145 probably benign Het
Tmem41b A G 7: 109,978,796 S94P possibly damaging Het
Trmt10b A T 4: 45,308,508 I223F possibly damaging Het
Tyrp1 G T 4: 80,844,826 G317* probably null Het
Urod T A 4: 116,990,282 probably benign Het
Vwf G T 6: 125,555,395 R52L probably damaging Het
Wnk2 C A 13: 49,057,167 Q232H probably damaging Het
Zbtb10 C A 3: 9,251,812 P228Q probably damaging Het
Other mutations in Dcaf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00787:Dcaf13 APN 15 39143632 nonsense probably null
IGL01081:Dcaf13 APN 15 39118806 missense probably damaging 1.00
IGL01766:Dcaf13 APN 15 39118750 missense probably benign 0.00
IGL02262:Dcaf13 APN 15 39118707 splice site probably benign
IGL02740:Dcaf13 APN 15 39145100 nonsense probably null
IGL03092:Dcaf13 APN 15 39127976 splice site probably benign
IGL03374:Dcaf13 APN 15 39145148 nonsense probably null
R0590:Dcaf13 UTSW 15 39145085 splice site probably benign
R0594:Dcaf13 UTSW 15 39123268 missense probably benign 0.00
R0711:Dcaf13 UTSW 15 39138089 missense probably damaging 1.00
R1036:Dcaf13 UTSW 15 39143718 missense probably damaging 1.00
R1770:Dcaf13 UTSW 15 39130238 missense probably damaging 1.00
R1826:Dcaf13 UTSW 15 39118899 missense probably damaging 1.00
R1933:Dcaf13 UTSW 15 39138088 missense probably damaging 0.99
R2508:Dcaf13 UTSW 15 39145152 missense probably benign
R4113:Dcaf13 UTSW 15 39130220 missense probably damaging 0.98
R4595:Dcaf13 UTSW 15 39118893 missense probably damaging 1.00
R4649:Dcaf13 UTSW 15 39138242 missense possibly damaging 0.54
R5431:Dcaf13 UTSW 15 39123224 missense probably benign 0.16
R5454:Dcaf13 UTSW 15 39124364 missense probably benign
R5834:Dcaf13 UTSW 15 39143642 nonsense probably null
R5929:Dcaf13 UTSW 15 39143653 missense possibly damaging 0.89
R5944:Dcaf13 UTSW 15 39146677 missense probably benign
R6319:Dcaf13 UTSW 15 39143672 missense probably benign 0.00
R6394:Dcaf13 UTSW 15 39143737 missense probably benign 0.04
R6664:Dcaf13 UTSW 15 39118888 missense probably damaging 1.00
R6884:Dcaf13 UTSW 15 39123240 missense probably damaging 1.00
R7419:Dcaf13 UTSW 15 39130220 missense probably damaging 0.98
Z1088:Dcaf13 UTSW 15 39145247 missense probably damaging 1.00
Posted On2015-04-16