Incidental Mutation 'IGL02175:Vmn1r75'
ID283058
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r75
Ensembl Gene ENSMUSG00000043308
Gene Namevomeronasal 1 receptor 75
SynonymsV1rg6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.048) question?
Stock #IGL02175
Quality Score
Status
Chromosome7
Chromosomal Location11874630-11884307 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 11880847 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 127 (C127R)
Ref Sequence ENSEMBL: ENSMUSP00000154156 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057229] [ENSMUST00000226622] [ENSMUST00000226855] [ENSMUST00000227611] [ENSMUST00000228268] [ENSMUST00000228463] [ENSMUST00000228646]
Predicted Effect probably damaging
Transcript: ENSMUST00000057229
AA Change: C169R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051510
Gene: ENSMUSG00000043308
AA Change: C169R

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.9e-10 PFAM
Pfam:V1R 35 293 1e-29 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226622
AA Change: C169R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000226855
AA Change: C169R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227611
AA Change: C127R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228268
AA Change: C127R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228463
AA Change: C169R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000228646
AA Change: C127R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 A T 8: 86,535,013 probably null Het
Adgrf5 A G 17: 43,451,010 I1199V probably damaging Het
Atm T A 9: 53,480,665 H1808L probably damaging Het
Cadps C T 14: 12,467,092 V942M probably damaging Het
Capns1 T C 7: 30,190,532 D116G probably benign Het
Ccdc110 T G 8: 45,940,623 M124R probably benign Het
Cdh23 T C 10: 60,331,308 N1855S possibly damaging Het
Dstyk T A 1: 132,449,391 L245* probably null Het
Dync2h1 A G 9: 7,111,548 Y289H possibly damaging Het
Efcab6 G A 15: 83,896,100 A1044V probably damaging Het
Egr1 T C 18: 34,863,055 S297P probably benign Het
Ercc6l2 T C 13: 63,869,190 probably benign Het
Frem2 C T 3: 53,655,599 A496T possibly damaging Het
Hook2 T A 8: 84,991,402 W53R probably damaging Het
Med19 T A 2: 84,678,663 probably null Het
Mgrn1 A G 16: 4,920,368 N262S probably benign Het
Nbas T G 12: 13,566,259 probably null Het
Ndc80 A C 17: 71,511,419 M314R probably benign Het
Nelfcd A T 2: 174,420,382 T89S probably benign Het
Nlrp4a A T 7: 26,475,097 E969D probably damaging Het
Ntrk3 A G 7: 78,247,228 V687A probably damaging Het
Oc90 A C 15: 65,883,825 S224R possibly damaging Het
Olfr1241 T C 2: 89,482,282 I284M possibly damaging Het
Plxnb1 C T 9: 109,100,846 H257Y possibly damaging Het
Prpf3 A G 3: 95,834,107 V579A probably damaging Het
Rarres1 T C 3: 67,495,756 N104S probably benign Het
Serpina1d T C 12: 103,765,696 probably null Het
Sik2 G A 9: 50,895,609 Q834* probably null Het
Slc39a10 G A 1: 46,818,128 A696V probably damaging Het
Snx13 T A 12: 35,132,062 N703K possibly damaging Het
Spaca9 T C 2: 28,695,924 I43V probably benign Het
Tor1aip2 T C 1: 156,065,006 S353P probably damaging Het
Trmt1l T C 1: 151,448,484 S361P probably benign Het
Trpm2 T C 10: 77,937,907 H558R probably benign Het
Zfp879 A T 11: 50,837,916 Y84N probably benign Het
Other mutations in Vmn1r75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01901:Vmn1r75 APN 7 11880812 missense probably damaging 1.00
IGL02399:Vmn1r75 APN 7 11881166 missense possibly damaging 0.82
IGL02648:Vmn1r75 APN 7 11881164 missense probably benign 0.04
IGL03372:Vmn1r75 APN 7 11880569 missense probably benign 0.29
R0538:Vmn1r75 UTSW 7 11880870 missense probably damaging 0.97
R0599:Vmn1r75 UTSW 7 11881262 splice site probably null
R3910:Vmn1r75 UTSW 7 11880830 missense possibly damaging 0.92
R4491:Vmn1r75 UTSW 7 11880982 missense probably damaging 0.97
R5566:Vmn1r75 UTSW 7 11880480 missense probably damaging 1.00
R6051:Vmn1r75 UTSW 7 11881051 missense probably damaging 1.00
R6230:Vmn1r75 UTSW 7 11881039 missense probably damaging 0.98
R6490:Vmn1r75 UTSW 7 11881076 missense probably damaging 1.00
R6570:Vmn1r75 UTSW 7 11880956 missense probably damaging 0.98
R7184:Vmn1r75 UTSW 7 11880988 nonsense probably null
R7189:Vmn1r75 UTSW 7 11880548 missense possibly damaging 0.93
R7501:Vmn1r75 UTSW 7 11881070 missense possibly damaging 0.67
R7973:Vmn1r75 UTSW 7 11881034 missense probably benign 0.04
R7997:Vmn1r75 UTSW 7 11880673 missense probably damaging 1.00
R8372:Vmn1r75 UTSW 7 11880730 missense probably benign 0.10
Posted On2015-04-16