Incidental Mutation 'IGL02175:Slc39a10'
ID 283075
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc39a10
Ensembl Gene ENSMUSG00000025986
Gene Name solute carrier family 39 (zinc transporter), member 10
Synonyms 2900042E17Rik, Zip10
Accession Numbers
Essential gene? Possibly essential (E-score: 0.622) question?
Stock # IGL02175
Quality Score
Status
Chromosome 1
Chromosomal Location 46846704-46932012 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 46857288 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 696 (A696V)
Ref Sequence ENSEMBL: ENSMUSP00000027131 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027131]
AlphaFold Q6P5F6
Predicted Effect probably damaging
Transcript: ENSMUST00000027131
AA Change: A696V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027131
Gene: ENSMUSG00000025986
AA Change: A696V

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 122 134 N/A INTRINSIC
low complexity region 170 195 N/A INTRINSIC
low complexity region 224 244 N/A INTRINSIC
Pfam:Zip 406 607 9.9e-44 PFAM
Pfam:Zip 588 821 2.5e-69 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141226
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice with conditional loss of function display defects in cellular proliferation and differentiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 A T 8: 87,261,642 (GRCm39) probably null Het
Adgrf5 A G 17: 43,761,901 (GRCm39) I1199V probably damaging Het
Atm T A 9: 53,391,965 (GRCm39) H1808L probably damaging Het
Cadps C T 14: 12,467,092 (GRCm38) V942M probably damaging Het
Capns1 T C 7: 29,889,957 (GRCm39) D116G probably benign Het
Ccdc110 T G 8: 46,393,660 (GRCm39) M124R probably benign Het
Cdh23 T C 10: 60,167,087 (GRCm39) N1855S possibly damaging Het
Dstyk T A 1: 132,377,129 (GRCm39) L245* probably null Het
Dync2h1 A G 9: 7,111,548 (GRCm39) Y289H possibly damaging Het
Efcab6 G A 15: 83,780,301 (GRCm39) A1044V probably damaging Het
Egr1 T C 18: 34,996,108 (GRCm39) S297P probably benign Het
Ercc6l2 T C 13: 64,017,004 (GRCm39) probably benign Het
Frem2 C T 3: 53,563,020 (GRCm39) A496T possibly damaging Het
Hook2 T A 8: 85,718,031 (GRCm39) W53R probably damaging Het
Med19 T A 2: 84,509,007 (GRCm39) probably null Het
Mgrn1 A G 16: 4,738,232 (GRCm39) N262S probably benign Het
Nbas T G 12: 13,616,260 (GRCm39) probably null Het
Ndc80 A C 17: 71,818,414 (GRCm39) M314R probably benign Het
Nelfcd A T 2: 174,262,175 (GRCm39) T89S probably benign Het
Nlrp4a A T 7: 26,174,522 (GRCm39) E969D probably damaging Het
Ntrk3 A G 7: 77,896,976 (GRCm39) V687A probably damaging Het
Oc90 A C 15: 65,755,674 (GRCm39) S224R possibly damaging Het
Or4a69 T C 2: 89,312,626 (GRCm39) I284M possibly damaging Het
Plxnb1 C T 9: 108,929,914 (GRCm39) H257Y possibly damaging Het
Prpf3 A G 3: 95,741,419 (GRCm39) V579A probably damaging Het
Rarres1 T C 3: 67,403,089 (GRCm39) N104S probably benign Het
Serpina1d T C 12: 103,731,955 (GRCm39) probably null Het
Sik2 G A 9: 50,806,909 (GRCm39) Q834* probably null Het
Snx13 T A 12: 35,182,061 (GRCm39) N703K possibly damaging Het
Spaca9 T C 2: 28,585,936 (GRCm39) I43V probably benign Het
Tor1aip2 T C 1: 155,940,752 (GRCm39) S353P probably damaging Het
Trmt1l T C 1: 151,324,235 (GRCm39) S361P probably benign Het
Trpm2 T C 10: 77,773,741 (GRCm39) H558R probably benign Het
Vmn1r75 T C 7: 11,614,774 (GRCm39) C127R probably damaging Het
Zfp879 A T 11: 50,728,743 (GRCm39) Y84N probably benign Het
Other mutations in Slc39a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00543:Slc39a10 APN 1 46,858,217 (GRCm39) splice site probably benign
IGL01628:Slc39a10 APN 1 46,874,683 (GRCm39) missense probably benign 0.23
IGL01939:Slc39a10 APN 1 46,871,895 (GRCm39) missense probably benign 0.07
IGL02068:Slc39a10 APN 1 46,858,599 (GRCm39) splice site probably benign
IGL02093:Slc39a10 APN 1 46,874,369 (GRCm39) missense probably damaging 1.00
IGL02101:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02122:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02125:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02171:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02186:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02699:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02700:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
R0217:Slc39a10 UTSW 1 46,874,700 (GRCm39) missense probably benign
R0704:Slc39a10 UTSW 1 46,875,021 (GRCm39) missense possibly damaging 0.76
R0782:Slc39a10 UTSW 1 46,875,156 (GRCm39) missense probably damaging 0.97
R1527:Slc39a10 UTSW 1 46,858,422 (GRCm39) missense probably benign
R1566:Slc39a10 UTSW 1 46,875,245 (GRCm39) missense possibly damaging 0.90
R1568:Slc39a10 UTSW 1 46,865,375 (GRCm39) missense probably benign 0.00
R1664:Slc39a10 UTSW 1 46,865,269 (GRCm39) missense probably damaging 1.00
R1830:Slc39a10 UTSW 1 46,875,230 (GRCm39) missense probably damaging 1.00
R1954:Slc39a10 UTSW 1 46,874,334 (GRCm39) missense possibly damaging 0.50
R2327:Slc39a10 UTSW 1 46,875,156 (GRCm39) missense probably damaging 0.97
R3434:Slc39a10 UTSW 1 46,874,877 (GRCm39) missense probably benign
R3761:Slc39a10 UTSW 1 46,851,285 (GRCm39) missense possibly damaging 0.88
R4035:Slc39a10 UTSW 1 46,851,234 (GRCm39) missense probably damaging 1.00
R4419:Slc39a10 UTSW 1 46,849,226 (GRCm39) missense probably benign 0.42
R4675:Slc39a10 UTSW 1 46,857,144 (GRCm39) intron probably benign
R4689:Slc39a10 UTSW 1 46,875,173 (GRCm39) missense probably benign 0.00
R5310:Slc39a10 UTSW 1 46,875,285 (GRCm39) missense probably damaging 1.00
R6073:Slc39a10 UTSW 1 46,871,772 (GRCm39) missense possibly damaging 0.68
R6161:Slc39a10 UTSW 1 46,866,567 (GRCm39) missense probably damaging 1.00
R6199:Slc39a10 UTSW 1 46,874,993 (GRCm39) missense probably damaging 1.00
R6562:Slc39a10 UTSW 1 46,874,724 (GRCm39) missense probably benign 0.02
R7087:Slc39a10 UTSW 1 46,874,880 (GRCm39) missense probably damaging 1.00
R7222:Slc39a10 UTSW 1 46,858,452 (GRCm39) missense possibly damaging 0.82
R7286:Slc39a10 UTSW 1 46,849,230 (GRCm39) missense probably damaging 0.97
R7568:Slc39a10 UTSW 1 46,874,290 (GRCm39) missense probably benign 0.14
R7891:Slc39a10 UTSW 1 46,851,328 (GRCm39) missense probably damaging 1.00
R7918:Slc39a10 UTSW 1 46,874,912 (GRCm39) missense possibly damaging 0.88
R9725:Slc39a10 UTSW 1 46,849,223 (GRCm39) missense probably damaging 1.00
RF020:Slc39a10 UTSW 1 46,849,175 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16