Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02176:Wdr89'

283093

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr89

Ensembl Gene

ENSMUSG00000045690

Gene Name

WD repeat domain 89

Synonyms

2600001A11Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02176

Quality Score

Status

Chromosome

Chromosomal Location

75677370-75716311 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 75679897 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 119 (I119N)

Ref Sequence

ENSEMBL: ENSMUSP00000140172 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062370] [ENSMUST00000187307]

AlphaFold

Q9D0R9

Predicted Effect

probably damaging
Transcript: ENSMUST00000062370
AA Change: I119N

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000050532
Gene: ENSMUSG00000045690
AA Change: I119N

Domain	Start	End	E-Value	Type
WD40	20	56	3.82e1	SMART
WD40	59	98	1.85e-3	SMART
WD40	103	147	2.64e2	SMART
WD40	157	198	6.38e-7	SMART
WD40	205	244	1.1e2	SMART
WD40	308	348	1.82e-2	SMART
low complexity region	366	379	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185426

Predicted Effect

probably damaging
Transcript: ENSMUST00000187307
AA Change: I119N

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000140172
Gene: ENSMUSG00000045690
AA Change: I119N

Domain	Start	End	E-Value	Type
WD40	20	56	3.82e1	SMART
WD40	59	98	1.85e-3	SMART
WD40	103	147	2.64e2	SMART
WD40	157	198	6.38e-7	SMART
WD40	205	244	1.1e2	SMART
WD40	308	348	1.82e-2	SMART
low complexity region	366	379	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191005

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahi1	G	T	10: 20,846,815 (GRCm39)	R415L	probably benign	Het
Ankle1	C	A	8: 71,858,903 (GRCm39)	H45Q	probably damaging	Het
Anks1b	A	T	10: 89,878,530 (GRCm39)	H113L	probably damaging	Het
Arhgap33	T	A	7: 30,223,476 (GRCm39)	H851L	possibly damaging	Het
Atp12a	C	T	14: 56,624,636 (GRCm39)	S972L	probably damaging	Het
Atrip	T	C	9: 108,896,114 (GRCm39)	D301G	probably benign	Het
Bckdk	A	G	7: 127,505,545 (GRCm39)	T223A	probably benign	Het
C3	C	A	17: 57,533,337 (GRCm39)		probably benign	Het
C8g	A	G	2: 25,389,122 (GRCm39)	S154P	probably damaging	Het
Casz1	A	G	4: 149,019,076 (GRCm39)	D459G	probably damaging	Het
Cdca7	A	G	2: 72,314,988 (GRCm39)	T293A	probably damaging	Het
Cmya5	T	A	13: 93,226,658 (GRCm39)	D2810V	probably damaging	Het
CN725425	G	A	15: 91,130,024 (GRCm39)	V296I	probably benign	Het
Col17a1	A	G	19: 47,639,658 (GRCm39)	M1077T	probably benign	Het
Ddhd1	A	T	14: 45,854,057 (GRCm39)	H426Q	probably damaging	Het
Dpp6	C	T	5: 27,928,575 (GRCm39)	T799M	probably damaging	Het
Efs	C	T	14: 55,158,499 (GRCm39)	G53D	probably damaging	Het
Fer1l4	A	G	2: 155,890,371 (GRCm39)	V221A	probably benign	Het
Gabre	G	A	X: 71,318,259 (GRCm39)	Q17*	probably null	Het
Gpld1	T	C	13: 25,168,192 (GRCm39)		probably null	Het
Gpr107	T	A	2: 31,058,858 (GRCm39)	V116D	probably benign	Het
Huwe1	T	C	X: 150,686,964 (GRCm39)	S2283P	possibly damaging	Het
Ksr1	A	G	11: 78,911,617 (GRCm39)	S722P	probably benign	Het
Lmbrd2	A	G	15: 9,182,661 (GRCm39)	E532G	probably damaging	Het
Lrfn1	T	C	7: 28,158,111 (GRCm39)		probably benign	Het
Lrrc4c	A	G	2: 97,460,598 (GRCm39)	D408G	probably damaging	Het
Mbp	A	G	18: 82,572,670 (GRCm39)	E122G	probably damaging	Het
Myo9a	T	A	9: 59,777,836 (GRCm39)	D1197E	probably benign	Het
Ncor1	A	T	11: 62,220,485 (GRCm39)		probably benign	Het
Or2y17	A	G	11: 49,232,133 (GRCm39)	Y258C	probably benign	Het
Pdcd1lg2	A	G	19: 29,414,732 (GRCm39)	E53G	probably benign	Het
Phex	G	T	X: 156,051,489 (GRCm39)	A469E	probably damaging	Het
Pigo	A	G	4: 43,019,352 (GRCm39)	S957P	probably benign	Het
Ppargc1b	T	A	18: 61,443,946 (GRCm39)	R406*	probably null	Het
Ppargc1b	C	A	18: 61,443,945 (GRCm39)	R422I	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Thnsl1	G	T	2: 21,216,665 (GRCm39)	A140S	possibly damaging	Het
Tm9sf3	A	G	19: 41,235,076 (GRCm39)		probably benign	Het
Tma7	T	A	9: 108,911,153 (GRCm39)		probably benign	Het
Tmtc2	T	G	10: 105,184,354 (GRCm39)	S514R	probably benign	Het
Unc79	G	A	12: 102,965,006 (GRCm39)		probably null	Het
Wiz	C	A	17: 32,575,876 (GRCm39)	R843S	probably damaging	Het
Zfp275	T	A	X: 72,396,889 (GRCm39)	S12T	probably damaging	Het

Other mutations in Wdr89

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00837:Wdr89	APN	12	75,679,825 (GRCm39)	nonsense	probably null
IGL02472:Wdr89	APN	12	75,679,743 (GRCm39)	missense	probably damaging	1.00
IGL02973:Wdr89	APN	12	75,679,873 (GRCm39)	missense	probably damaging	0.98
R0003:Wdr89	UTSW	12	75,679,367 (GRCm39)	missense	probably benign	0.00
R2060:Wdr89	UTSW	12	75,679,762 (GRCm39)	missense	probably damaging	1.00
R4494:Wdr89	UTSW	12	75,679,521 (GRCm39)	missense	probably damaging	1.00
R5120:Wdr89	UTSW	12	75,679,412 (GRCm39)	missense	probably damaging	1.00
R5195:Wdr89	UTSW	12	75,680,062 (GRCm39)	missense	probably benign	0.23
R6572:Wdr89	UTSW	12	75,680,159 (GRCm39)	missense	probably damaging	1.00
R7487:Wdr89	UTSW	12	75,679,388 (GRCm39)	missense	probably benign
R7835:Wdr89	UTSW	12	75,679,673 (GRCm39)	missense	probably damaging	1.00
R8445:Wdr89	UTSW	12	75,679,636 (GRCm39)	missense	probably damaging	0.99
R8765:Wdr89	UTSW	12	75,679,688 (GRCm39)	missense	probably damaging	1.00
R9202:Wdr89	UTSW	12	75,679,943 (GRCm39)	missense	probably benign	0.00
R9269:Wdr89	UTSW	12	75,679,564 (GRCm39)	missense	possibly damaging	0.50
R9340:Wdr89	UTSW	12	75,679,937 (GRCm39)	missense	probably benign	0.11
R9522:Wdr89	UTSW	12	75,679,924 (GRCm39)	missense	probably damaging	1.00
R9557:Wdr89	UTSW	12	75,679,666 (GRCm39)	missense	probably damaging	1.00
R9760:Wdr89	UTSW	12	75,680,026 (GRCm39)	missense	probably damaging	0.99
X0023:Wdr89	UTSW	12	75,679,951 (GRCm39)	missense	probably benign

Posted On

2015-04-16