Incidental Mutation 'IGL00907:Armt1'
ID28311
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Armt1
Ensembl Gene ENSMUSG00000061759
Gene Nameacidic residue methyltransferase 1
Synonyms1700052N19Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #IGL00907
Quality Score
Status
Chromosome10
Chromosomal Location4432467-4455141 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 4454051 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Valine at position 379 (F379V)
Ref Sequence ENSEMBL: ENSMUSP00000093581 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095893] [ENSMUST00000118544] [ENSMUST00000152294]
Predicted Effect possibly damaging
Transcript: ENSMUST00000095893
AA Change: F379V

PolyPhen 2 Score 0.504 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000093581
Gene: ENSMUSG00000061759
AA Change: F379V

DomainStartEndE-ValueType
Pfam:DUF89 20 417 1.3e-125 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118544
SMART Domains Protein: ENSMUSP00000114073
Gene: ENSMUSG00000061759

DomainStartEndE-ValueType
Pfam:DUF89 20 187 1.2e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143037
Predicted Effect probably benign
Transcript: ENSMUST00000152294
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp8b1 T C 18: 64,561,705 D502G possibly damaging Het
Brwd3 A G X: 108,784,246 probably benign Het
Ccdc171 T A 4: 83,864,249 H1259Q probably damaging Het
Chd7 T C 4: 8,840,435 I1401T probably damaging Het
Csf1 T C 3: 107,750,346 N76S probably damaging Het
Dld A G 12: 31,332,330 probably benign Het
Eif5 T A 12: 111,540,555 I141N probably damaging Het
Etl4 G A 2: 20,766,478 G674D possibly damaging Het
Fam234a G A 17: 26,213,526 R550W probably damaging Het
Hipk2 A G 6: 38,818,273 S347P probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Hsd17b2 A T 8: 117,734,694 I157L probably benign Het
Ibtk A G 9: 85,690,331 S1269P possibly damaging Het
Igsf3 T C 3: 101,427,448 probably benign Het
Kin G A 2: 10,080,704 R25H probably damaging Het
Kin T C 2: 10,080,706 W26R probably damaging Het
Kir3dl1 G A X: 136,525,162 C95Y probably damaging Het
Lamc2 A G 1: 153,144,651 V383A probably benign Het
Mael A G 1: 166,204,849 Y314H probably damaging Het
Npat T C 9: 53,563,290 V794A possibly damaging Het
Nr4a2 T A 2: 57,109,217 I340F probably damaging Het
Olfr1195 A G 2: 88,683,294 V146A probably benign Het
Olfr477 A T 7: 107,990,890 D175V probably damaging Het
Olfr836 T A 9: 19,121,232 D89E possibly damaging Het
Pdcd11 T C 19: 47,107,564 V641A probably benign Het
Phf24 C T 4: 42,938,667 T264I probably benign Het
Sars2 G T 7: 28,753,423 probably benign Het
Scn1a A C 2: 66,327,797 S411A probably damaging Het
Srsf5 T C 12: 80,947,834 V112A probably damaging Het
Susd2 T C 10: 75,640,931 N206S probably benign Het
Thrap3 C T 4: 126,165,578 G892S probably benign Het
Ttc32 T A 12: 9,034,953 Y58N probably damaging Het
Other mutations in Armt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Armt1 APN 10 4450732 missense probably benign
IGL01018:Armt1 APN 10 4454237 unclassified probably benign
IGL02198:Armt1 APN 10 4454064 missense possibly damaging 0.95
IGL02980:Armt1 APN 10 4450643 splice site probably benign
IGL03104:Armt1 APN 10 4439615 missense possibly damaging 0.94
R0620:Armt1 UTSW 10 4432689 missense probably benign 0.38
R4248:Armt1 UTSW 10 4439687 missense probably benign 0.00
R5709:Armt1 UTSW 10 4434903 missense probably damaging 0.97
R6058:Armt1 UTSW 10 4453488 missense probably damaging 1.00
R6318:Armt1 UTSW 10 4450859 missense probably benign 0.01
R6410:Armt1 UTSW 10 4453826 missense probably benign
R6998:Armt1 UTSW 10 4453937 missense probably benign 0.03
R7242:Armt1 UTSW 10 4453475 missense probably damaging 1.00
R7268:Armt1 UTSW 10 4450855 missense possibly damaging 0.75
R7432:Armt1 UTSW 10 4432706 missense probably benign 0.00
R7640:Armt1 UTSW 10 4453572 missense probably damaging 0.97
R7715:Armt1 UTSW 10 4450751 missense probably benign 0.01
Posted On2013-04-17