Incidental Mutation 'IGL02176:Pdcd1lg2'
ID 283115
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pdcd1lg2
Ensembl Gene ENSMUSG00000016498
Gene Name programmed cell death 1 ligand 2
Synonyms B7-DC, PD-L2, F730015O22Rik, Btdc
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # IGL02176
Quality Score
Status
Chromosome 19
Chromosomal Location 29388319-29448561 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 29414732 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 53 (E53G)
Ref Sequence ENSEMBL: ENSMUSP00000108195 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112576]
AlphaFold Q9WUL5
PDB Structure Crystal structure of the receptor binding domain of mouse PD-L2 [X-RAY DIFFRACTION]
Crystal structure of the mouse PD-1 and PD-L2 complex [X-RAY DIFFRACTION]
Crystal structure of the mouse PD-1 Mutant and PD-L2 complex [X-RAY DIFFRACTION]
Crystal structure of the complex between mouse PD-1 mutant and PD-L2 IgV domain [X-RAY DIFFRACTION]
Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and PD-L2 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000112576
AA Change: E53G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000108195
Gene: ENSMUSG00000016498
AA Change: E53G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IG 27 120 4.43e-5 SMART
Pfam:Ig_3 125 196 5.3e-6 PFAM
Pfam:C2-set_2 126 202 6.6e-7 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene have dendritic cells that display a diminished ability to activate CD4+ T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahi1 G T 10: 20,846,815 (GRCm39) R415L probably benign Het
Ankle1 C A 8: 71,858,903 (GRCm39) H45Q probably damaging Het
Anks1b A T 10: 89,878,530 (GRCm39) H113L probably damaging Het
Arhgap33 T A 7: 30,223,476 (GRCm39) H851L possibly damaging Het
Atp12a C T 14: 56,624,636 (GRCm39) S972L probably damaging Het
Atrip T C 9: 108,896,114 (GRCm39) D301G probably benign Het
Bckdk A G 7: 127,505,545 (GRCm39) T223A probably benign Het
C3 C A 17: 57,533,337 (GRCm39) probably benign Het
C8g A G 2: 25,389,122 (GRCm39) S154P probably damaging Het
Casz1 A G 4: 149,019,076 (GRCm39) D459G probably damaging Het
Cdca7 A G 2: 72,314,988 (GRCm39) T293A probably damaging Het
Cmya5 T A 13: 93,226,658 (GRCm39) D2810V probably damaging Het
CN725425 G A 15: 91,130,024 (GRCm39) V296I probably benign Het
Col17a1 A G 19: 47,639,658 (GRCm39) M1077T probably benign Het
Ddhd1 A T 14: 45,854,057 (GRCm39) H426Q probably damaging Het
Dpp6 C T 5: 27,928,575 (GRCm39) T799M probably damaging Het
Efs C T 14: 55,158,499 (GRCm39) G53D probably damaging Het
Fer1l4 A G 2: 155,890,371 (GRCm39) V221A probably benign Het
Gabre G A X: 71,318,259 (GRCm39) Q17* probably null Het
Gpld1 T C 13: 25,168,192 (GRCm39) probably null Het
Gpr107 T A 2: 31,058,858 (GRCm39) V116D probably benign Het
Huwe1 T C X: 150,686,964 (GRCm39) S2283P possibly damaging Het
Ksr1 A G 11: 78,911,617 (GRCm39) S722P probably benign Het
Lmbrd2 A G 15: 9,182,661 (GRCm39) E532G probably damaging Het
Lrfn1 T C 7: 28,158,111 (GRCm39) probably benign Het
Lrrc4c A G 2: 97,460,598 (GRCm39) D408G probably damaging Het
Mbp A G 18: 82,572,670 (GRCm39) E122G probably damaging Het
Myo9a T A 9: 59,777,836 (GRCm39) D1197E probably benign Het
Ncor1 A T 11: 62,220,485 (GRCm39) probably benign Het
Or2y17 A G 11: 49,232,133 (GRCm39) Y258C probably benign Het
Phex G T X: 156,051,489 (GRCm39) A469E probably damaging Het
Pigo A G 4: 43,019,352 (GRCm39) S957P probably benign Het
Ppargc1b T A 18: 61,443,946 (GRCm39) R406* probably null Het
Ppargc1b C A 18: 61,443,945 (GRCm39) R422I probably damaging Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Thnsl1 G T 2: 21,216,665 (GRCm39) A140S possibly damaging Het
Tm9sf3 A G 19: 41,235,076 (GRCm39) probably benign Het
Tma7 T A 9: 108,911,153 (GRCm39) probably benign Het
Tmtc2 T G 10: 105,184,354 (GRCm39) S514R probably benign Het
Unc79 G A 12: 102,965,006 (GRCm39) probably null Het
Wdr89 A T 12: 75,679,897 (GRCm39) I119N probably damaging Het
Wiz C A 17: 32,575,876 (GRCm39) R843S probably damaging Het
Zfp275 T A X: 72,396,889 (GRCm39) S12T probably damaging Het
Other mutations in Pdcd1lg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00502:Pdcd1lg2 APN 19 29,423,462 (GRCm39) missense possibly damaging 0.96
IGL03184:Pdcd1lg2 APN 19 29,431,911 (GRCm39) missense probably benign 0.00
R4992:Pdcd1lg2 UTSW 19 29,423,484 (GRCm39) missense probably damaging 1.00
R5991:Pdcd1lg2 UTSW 19 29,431,867 (GRCm39) missense probably benign
R6006:Pdcd1lg2 UTSW 19 29,431,905 (GRCm39) missense possibly damaging 0.58
R6035:Pdcd1lg2 UTSW 19 29,423,435 (GRCm39) missense probably benign 0.08
R6035:Pdcd1lg2 UTSW 19 29,423,435 (GRCm39) missense probably benign 0.08
R6393:Pdcd1lg2 UTSW 19 29,414,698 (GRCm39) missense probably damaging 1.00
R8884:Pdcd1lg2 UTSW 19 29,423,318 (GRCm39) critical splice acceptor site probably null
R8943:Pdcd1lg2 UTSW 19 29,423,553 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16