Incidental Mutation 'IGL02177:Olfr1412'
ID283138
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1412
Ensembl Gene ENSMUSG00000046300
Gene Nameolfactory receptor 1412
SynonymsGA_x6K02T2R7CC-81165686-81164721, MOR208-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL02177
Quality Score
Status
Chromosome1
Chromosomal Location92585779-92591375 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 92588757 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 142 (M142I)
Ref Sequence ENSEMBL: ENSMUSP00000150943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062964] [ENSMUST00000190505]
Predicted Effect possibly damaging
Transcript: ENSMUST00000062964
AA Change: M142I

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000060291
Gene: ENSMUSG00000046300
AA Change: M142I

DomainStartEndE-ValueType
transmembrane domain 10 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.8e-47 PFAM
Pfam:7tm_1 48 321 1.4e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000190505
AA Change: M142I

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204141
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add3 T G 19: 53,216,892 Y24* probably null Het
Catsperb A G 12: 101,541,462 Y496C probably damaging Het
Ccdc183 C T 2: 25,612,083 E260K probably benign Het
Ccdc81 A C 7: 89,875,780 M531R possibly damaging Het
Cyp3a16 T A 5: 145,450,154 N342I probably benign Het
Defb43 T C 14: 63,011,817 V3A probably benign Het
Dpyd T A 3: 119,064,910 I591N possibly damaging Het
Dpysl5 T G 5: 30,745,278 V18G probably damaging Het
Erc2 A T 14: 27,898,623 M69L probably benign Het
Fam184b G T 5: 45,532,815 Y817* probably null Het
Fyb G T 15: 6,658,566 probably null Het
Gpr33 G T 12: 52,024,080 Q59K probably benign Het
Heatr3 T G 8: 88,156,723 F278V probably benign Het
Hectd1 A T 12: 51,772,320 D1292E probably damaging Het
Herc1 A T 9: 66,434,511 M1861L probably benign Het
Hspg2 T A 4: 137,515,316 L614Q probably damaging Het
Itpr3 A G 17: 27,099,614 R915G possibly damaging Het
Jhy T C 9: 40,898,257 D646G probably damaging Het
Lrig1 T A 6: 94,663,996 N76I possibly damaging Het
Macc1 A G 12: 119,465,557 D814G probably damaging Het
Mapk8ip1 T C 2: 92,386,747 D401G probably damaging Het
Nedd4 T A 9: 72,747,157 S865T probably damaging Het
Pi4ka A T 16: 17,318,282 D937E probably benign Het
Prkcd T A 14: 30,605,887 I81F probably damaging Het
Ranbp9 A T 13: 43,419,717 C280S probably damaging Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Scn1b T C 7: 31,117,230 *219W probably null Het
Slain2 T C 5: 72,914,665 V14A probably benign Het
Soat1 A T 1: 156,440,503 probably benign Het
Tbc1d4 T A 14: 101,454,939 M1030L possibly damaging Het
Tenm4 T C 7: 96,895,662 V2295A probably benign Het
Tmem135 A G 7: 89,338,453 Y46H probably damaging Het
Tnfsf18 A T 1: 161,503,785 D168V probably damaging Het
Trdn T C 10: 33,139,173 V41A probably damaging Het
Trpc5 G T X: 144,481,238 L208I probably damaging Het
Vmn1r50 T C 6: 90,108,157 Y295H probably benign Het
Vmn2r18 T G 5: 151,586,809 H33P possibly damaging Het
Vmn2r84 T C 10: 130,392,012 I118M probably benign Het
Other mutations in Olfr1412
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01472:Olfr1412 APN 1 92588972 missense possibly damaging 0.52
IGL02507:Olfr1412 APN 1 92588926 missense possibly damaging 0.68
IGL02888:Olfr1412 APN 1 92589203 missense probably damaging 1.00
IGL03001:Olfr1412 APN 1 92588551 missense probably damaging 1.00
R1771:Olfr1412 UTSW 1 92589115 missense probably benign 0.03
R1780:Olfr1412 UTSW 1 92588389 missense probably benign 0.01
R2215:Olfr1412 UTSW 1 92588986 missense probably benign 0.00
R2437:Olfr1412 UTSW 1 92588966 missense possibly damaging 0.46
R3176:Olfr1412 UTSW 1 92588813 missense probably benign 0.32
R3177:Olfr1412 UTSW 1 92588813 missense probably benign 0.32
R3276:Olfr1412 UTSW 1 92588813 missense probably benign 0.32
R3277:Olfr1412 UTSW 1 92588813 missense probably benign 0.32
R4475:Olfr1412 UTSW 1 92588579 missense probably benign 0.00
R4892:Olfr1412 UTSW 1 92588921 missense probably benign 0.05
R5910:Olfr1412 UTSW 1 92588707 missense probably damaging 1.00
R6808:Olfr1412 UTSW 1 92589046 missense probably damaging 0.99
R7130:Olfr1412 UTSW 1 92588912 missense probably benign 0.10
R7476:Olfr1412 UTSW 1 92589264 missense probably benign
Z1088:Olfr1412 UTSW 1 92588551 missense probably damaging 1.00
Z1177:Olfr1412 UTSW 1 92588378 nonsense probably null
Posted On2015-04-16