Incidental Mutation 'IGL02179:Cdk15'
ID283251
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk15
Ensembl Gene ENSMUSG00000026023
Gene Namecyclin-dependent kinase 15
SynonymsAls2cr7, Pftk2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02179
Quality Score
Status
Chromosome1
Chromosomal Location59256906-59352993 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 59330941 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Serine at position 381 (A381S)
Ref Sequence ENSEMBL: ENSMUSP00000124680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114248] [ENSMUST00000160662]
Predicted Effect possibly damaging
Transcript: ENSMUST00000114248
AA Change: A379S

PolyPhen 2 Score 0.840 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000109886
Gene: ENSMUSG00000026023
AA Change: A379S

DomainStartEndE-ValueType
S_TKc 101 385 7.9e-86 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000160662
AA Change: A381S

PolyPhen 2 Score 0.840 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000124680
Gene: ENSMUSG00000026023
AA Change: A381S

DomainStartEndE-ValueType
S_TKc 103 387 7.9e-86 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162906
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 C A 2: 31,792,249 A385D probably damaging Het
Ace A G 11: 105,969,789 D174G probably benign Het
Aldh1l2 A G 10: 83,522,837 V98A probably benign Het
AU040320 T A 4: 126,835,612 F522L probably benign Het
Ccdc73 A G 2: 104,907,568 D3G probably damaging Het
Cdk14 A C 5: 5,103,845 L199V probably damaging Het
Cyb5a A G 18: 84,873,155 I68V probably benign Het
Dock5 G A 14: 67,806,496 probably benign Het
Fbxw24 T A 9: 109,609,905 K201* probably null Het
Gm5852 C T 3: 93,727,716 noncoding transcript Het
Gsdma3 A G 11: 98,635,271 K274E possibly damaging Het
Hoxa7 T A 6: 52,215,874 Q178L probably damaging Het
Itgae G T 11: 73,134,018 V992L probably benign Het
Klk1b26 A G 7: 44,016,312 N183D probably benign Het
Krt39 A T 11: 99,520,841 S140T probably damaging Het
Lama2 G A 10: 27,070,364 T1953I probably benign Het
Mmp1a G A 9: 7,464,273 R26Q probably benign Het
Myh7b A C 2: 155,614,491 I175L probably benign Het
Nol11 A G 11: 107,189,256 M1T probably null Het
Nrxn1 T A 17: 90,630,083 I641F probably damaging Het
Olfr1047 A T 2: 86,228,247 C241* probably null Het
Olfr1501 T C 19: 13,838,487 T229A probably benign Het
Olfr610 A C 7: 103,506,727 L73R probably damaging Het
Parn G T 16: 13,667,592 H13Q probably benign Het
Pcnx T C 12: 81,933,719 probably benign Het
Pdcd10 T C 3: 75,527,615 D60G probably damaging Het
Phka2 G A X: 160,554,380 probably null Het
Ppargc1a A T 5: 51,473,711 D525E possibly damaging Het
Rad54l2 C A 9: 106,720,390 R139L probably damaging Het
Rnf20 T C 4: 49,638,712 V178A probably benign Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Sdccag8 C T 1: 176,878,056 H479Y probably benign Het
Taf8 T C 17: 47,502,233 T13A probably benign Het
Ttc8 T C 12: 98,964,537 L270P possibly damaging Het
Ttn G A 2: 76,887,368 Q365* probably null Het
Uchl1 A G 5: 66,676,294 Q2R probably benign Het
Ufl1 A G 4: 25,254,896 V440A probably damaging Het
Other mutations in Cdk15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01307:Cdk15 APN 1 59287796 missense probably benign 0.37
IGL01612:Cdk15 APN 1 59289773 missense possibly damaging 0.93
IGL03228:Cdk15 APN 1 59258753 missense possibly damaging 0.95
FR4449:Cdk15 UTSW 1 59257823 small insertion probably benign
R0270:Cdk15 UTSW 1 59310806 missense probably damaging 0.99
R1720:Cdk15 UTSW 1 59289758 missense probably damaging 1.00
R1958:Cdk15 UTSW 1 59344316 missense probably damaging 0.99
R1969:Cdk15 UTSW 1 59330951 missense probably damaging 1.00
R3159:Cdk15 UTSW 1 59301281 missense probably damaging 1.00
R6000:Cdk15 UTSW 1 59289659 missense probably damaging 1.00
R6226:Cdk15 UTSW 1 59265633 missense probably damaging 1.00
R6257:Cdk15 UTSW 1 59257105 critical splice donor site probably null
R7184:Cdk15 UTSW 1 59265655 missense probably benign 0.33
R7446:Cdk15 UTSW 1 59289695 missense probably damaging 1.00
R7467:Cdk15 UTSW 1 59289779 missense probably null 0.96
Posted On2015-04-16