Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02182:Zfp618'

283298

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp618

Ensembl Gene

ENSMUSG00000028358

Gene Name

zinc finger protein 618

Synonyms

Nedd10, 2810040O04Rik, D430033D05Rik, 2810031P15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

IGL02182

Quality Score

Status

Chromosome

Chromosomal Location

62883810-63057945 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 63013798 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000103038 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030043] [ENSMUST00000064814] [ENSMUST00000107415]

AlphaFold

Q80YY7

Predicted Effect

probably benign
Transcript: ENSMUST00000030043

SMART Domains

Protein: ENSMUSP00000030043
Gene: ENSMUSG00000028358

Domain	Start	End	E-Value	Type
ZnF_C2H2	90	112	5.06e-2	SMART
ZnF_C2H2	131	153	8.81e-2	SMART
ZnF_C2H2	199	221	2.91e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000064814

SMART Domains

Protein: ENSMUSP00000069275
Gene: ENSMUSG00000028358

Domain	Start	End	E-Value	Type
ZnF_C2H2	114	136	5.06e-2	SMART
ZnF_C2H2	155	177	8.81e-2	SMART
ZnF_C2H2	243	265	2.91e-2	SMART
low complexity region	288	295	N/A	INTRINSIC
ZnF_C2H2	298	320	2.53e-2	SMART
PDB:2BW3\|A	377	690	5e-8	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000107415

SMART Domains

Protein: ENSMUSP00000103038
Gene: ENSMUSG00000028358

Domain	Start	End	E-Value	Type
ZnF_C2H2	146	168	5.06e-2	SMART
ZnF_C2H2	187	209	8.81e-2	SMART
ZnF_C2H2	255	277	2.91e-2	SMART
low complexity region	381	388	N/A	INTRINSIC
ZnF_C2H2	391	413	2.53e-2	SMART
PDB:2BW3\|A	479	783	9e-8	PDB

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam34	T	A	8: 44,104,790 (GRCm39)	N285I	probably benign	Het
Adprh	T	C	16: 38,267,838 (GRCm39)	H149R	probably benign	Het
Ahctf1	A	G	1: 179,580,643 (GRCm39)	V1853A	probably benign	Het
Ank1	T	C	8: 23,603,868 (GRCm39)	V905A	possibly damaging	Het
Atp10b	T	G	11: 43,139,774 (GRCm39)	L1234R	probably damaging	Het
Bco1	G	A	8: 117,859,805 (GRCm39)	A503T	probably damaging	Het
Clxn	T	A	16: 14,738,659 (GRCm39)	D163E	probably damaging	Het
Cpz	T	A	5: 35,675,066 (GRCm39)	Y61F	probably damaging	Het
Dnah8	T	A	17: 31,013,737 (GRCm39)	M3826K	possibly damaging	Het
Dtd2	A	G	12: 52,046,492 (GRCm39)	S116P	probably benign	Het
Eml5	T	C	12: 98,768,581 (GRCm39)	D1498G	probably damaging	Het
Fat4	T	C	3: 38,944,695 (GRCm39)	V1196A	probably damaging	Het
Gm15557	T	C	2: 155,783,737 (GRCm39)	D405G	probably damaging	Het
Lpp	C	T	16: 24,580,895 (GRCm39)	R204W	probably damaging	Het
Mfsd11	T	A	11: 116,764,740 (GRCm39)	V388E	possibly damaging	Het
Ms4a20	A	T	19: 11,074,436 (GRCm39)		probably benign	Het
Or10a3m	A	G	7: 108,313,075 (GRCm39)	T160A	probably benign	Het
Or52b4	A	G	7: 102,184,775 (GRCm39)	I274V	probably benign	Het
Pik3cg	A	T	12: 32,255,272 (GRCm39)	D238E	possibly damaging	Het
Plcb3	T	C	19: 6,946,988 (GRCm39)	H9R	probably benign	Het
Ppp3cc	A	C	14: 70,462,473 (GRCm39)	V388G	probably benign	Het
Ranbp2	T	A	10: 58,321,582 (GRCm39)	C2626*	probably null	Het
Resp18	T	C	1: 75,250,615 (GRCm39)	T155A	probably benign	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Scarb2	C	T	5: 92,601,913 (GRCm39)	S327N	probably damaging	Het
Secisbp2l	T	A	2: 125,589,497 (GRCm39)	I684F	probably damaging	Het
Slc39a6	T	C	18: 24,734,347 (GRCm39)	D114G	probably damaging	Het
Smap1	T	A	1: 23,898,180 (GRCm39)	E85D	probably damaging	Het
Tas2r121	T	A	6: 132,677,133 (GRCm39)	I280F	probably damaging	Het
Uhrf2	T	C	19: 30,016,609 (GRCm39)	V86A	probably benign	Het
Vip	A	T	10: 5,593,561 (GRCm39)	Y91F	probably benign	Het
Zfp318	C	T	17: 46,707,736 (GRCm39)	R265*	probably null	Het

Other mutations in Zfp618

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01301:Zfp618	APN	4	63,051,063 (GRCm39)	missense	probably damaging	1.00
IGL01563:Zfp618	APN	4	62,998,133 (GRCm39)	missense	probably benign	0.38
IGL01726:Zfp618	APN	4	63,050,872 (GRCm39)	missense	probably damaging	1.00
IGL02139:Zfp618	APN	4	63,051,773 (GRCm39)	missense	probably damaging	1.00
IGL02533:Zfp618	APN	4	63,007,642 (GRCm39)	missense	probably damaging	1.00
IGL03231:Zfp618	APN	4	63,012,716 (GRCm39)	missense	probably damaging	1.00
IGL03257:Zfp618	APN	4	63,050,908 (GRCm39)	missense	probably damaging	1.00
ANU18:Zfp618	UTSW	4	63,051,063 (GRCm39)	missense	probably damaging	1.00
IGL03014:Zfp618	UTSW	4	62,998,325 (GRCm39)	missense	probably damaging	1.00
R0288:Zfp618	UTSW	4	63,051,171 (GRCm39)	missense	possibly damaging	0.57
R0408:Zfp618	UTSW	4	63,004,809 (GRCm39)	missense	probably damaging	0.97
R0685:Zfp618	UTSW	4	63,052,011 (GRCm39)	missense	probably benign	0.21
R1482:Zfp618	UTSW	4	63,033,685 (GRCm39)	missense	possibly damaging	0.64
R1585:Zfp618	UTSW	4	63,051,175 (GRCm39)	missense	probably damaging	1.00
R1649:Zfp618	UTSW	4	63,013,774 (GRCm39)	missense	probably damaging	1.00
R1744:Zfp618	UTSW	4	63,004,871 (GRCm39)	splice site	probably benign
R1793:Zfp618	UTSW	4	63,051,474 (GRCm39)	missense	probably damaging	0.97
R1952:Zfp618	UTSW	4	63,050,555 (GRCm39)	splice site	probably null
R1996:Zfp618	UTSW	4	63,049,452 (GRCm39)	splice site	probably null
R3792:Zfp618	UTSW	4	63,033,728 (GRCm39)	intron	probably benign
R3803:Zfp618	UTSW	4	63,051,256 (GRCm39)	missense	probably damaging	1.00
R3821:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R3838:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4009:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4010:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4565:Zfp618	UTSW	4	63,039,588 (GRCm39)	missense	probably damaging	1.00
R4611:Zfp618	UTSW	4	63,051,216 (GRCm39)	missense	probably damaging	1.00
R5019:Zfp618	UTSW	4	63,021,789 (GRCm39)	missense	probably damaging	1.00
R5154:Zfp618	UTSW	4	63,051,446 (GRCm39)	missense	probably damaging	1.00
R5183:Zfp618	UTSW	4	63,017,519 (GRCm39)	missense	probably benign
R5354:Zfp618	UTSW	4	62,998,265 (GRCm39)	missense	probably damaging	1.00
R5383:Zfp618	UTSW	4	63,013,729 (GRCm39)	missense	probably benign	0.33
R5774:Zfp618	UTSW	4	63,050,799 (GRCm39)	missense	probably damaging	1.00
R5932:Zfp618	UTSW	4	63,036,803 (GRCm39)	nonsense	probably null
R6101:Zfp618	UTSW	4	63,051,478 (GRCm39)	missense	probably benign	0.09
R6105:Zfp618	UTSW	4	63,051,478 (GRCm39)	missense	probably benign	0.09
R6478:Zfp618	UTSW	4	63,050,943 (GRCm39)	missense	probably damaging	1.00
R6598:Zfp618	UTSW	4	63,007,636 (GRCm39)	missense	probably damaging	1.00
R7386:Zfp618	UTSW	4	63,013,622 (GRCm39)	critical splice donor site	probably null
R7666:Zfp618	UTSW	4	63,050,954 (GRCm39)	nonsense	probably null
R7678:Zfp618	UTSW	4	63,004,858 (GRCm39)	missense	probably benign	0.07
R7975:Zfp618	UTSW	4	63,049,352 (GRCm39)	missense	possibly damaging	0.93
R8276:Zfp618	UTSW	4	63,051,193 (GRCm39)	missense	probably damaging	1.00
R8421:Zfp618	UTSW	4	63,051,483 (GRCm39)	missense	probably damaging	1.00
R8988:Zfp618	UTSW	4	63,012,708 (GRCm39)	missense	probably benign	0.09
R9022:Zfp618	UTSW	4	63,012,687 (GRCm39)	missense	probably damaging	1.00
R9150:Zfp618	UTSW	4	63,039,603 (GRCm39)	nonsense	probably null
R9163:Zfp618	UTSW	4	63,051,511 (GRCm39)	missense	probably damaging	1.00
R9364:Zfp618	UTSW	4	63,036,824 (GRCm39)	missense	probably damaging	0.99
R9382:Zfp618	UTSW	4	63,051,258 (GRCm39)	missense	probably damaging	0.97
R9424:Zfp618	UTSW	4	63,051,282 (GRCm39)	missense	probably benign	0.00
R9462:Zfp618	UTSW	4	63,051,510 (GRCm39)	missense	possibly damaging	0.94
R9576:Zfp618	UTSW	4	63,051,282 (GRCm39)	missense	probably benign	0.00
R9587:Zfp618	UTSW	4	63,051,916 (GRCm39)	missense
X0011:Zfp618	UTSW	4	62,998,243 (GRCm39)	missense	probably damaging	0.99
Z1176:Zfp618	UTSW	4	63,051,000 (GRCm39)	missense	probably benign	0.12
Z1176:Zfp618	UTSW	4	63,013,734 (GRCm39)	missense	probably benign	0.29

Posted On

2015-04-16