Incidental Mutation 'IGL00929:Soga3'
ID28339
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Soga3
Ensembl Gene ENSMUSG00000038916
Gene NameSOGA family member 3
Synonyms6330407J23Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.191) question?
Stock #IGL00929
Quality Score
Status
Chromosome10
Chromosomal Location29143839-29199630 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 29148292 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 401 (N401K)
Ref Sequence ENSEMBL: ENSMUSP00000090293 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092629] [ENSMUST00000216757]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000070359
SMART Domains Protein: ENSMUSP00000063425
Gene: ENSMUSG00000056316

DomainStartEndE-ValueType
low complexity region 65 83 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000092629
AA Change: N401K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000090293
Gene: ENSMUSG00000038916
AA Change: N401K

DomainStartEndE-ValueType
low complexity region 4 23 N/A INTRINSIC
low complexity region 72 81 N/A INTRINSIC
low complexity region 86 101 N/A INTRINSIC
low complexity region 110 126 N/A INTRINSIC
low complexity region 158 185 N/A INTRINSIC
low complexity region 214 247 N/A INTRINSIC
SCOP:d1fxkc_ 354 488 2e-4 SMART
Blast:BRLZ 356 384 6e-10 BLAST
Pfam:DUF3166 519 613 1.8e-34 PFAM
Pfam:DUF3166 639 727 4.6e-34 PFAM
transmembrane domain 917 939 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213243
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213451
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214863
Predicted Effect probably benign
Transcript: ENSMUST00000216757
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp1 A T 12: 30,904,900 H67Q probably damaging Het
Ankrd13b A G 11: 77,472,752 S247P probably damaging Het
Aqp4 C T 18: 15,393,599 G275E probably benign Het
Arhgef15 A T 11: 68,954,102 L223Q probably damaging Het
Asb13 A G 13: 3,649,427 Y209C probably damaging Het
Cdk18 A G 1: 132,118,519 probably null Het
Cntnap5a G A 1: 116,060,274 probably null Het
Cops6 A G 5: 138,161,386 M1V probably null Het
Dab2ip A T 2: 35,708,877 M137L possibly damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Lemd1 A G 1: 132,256,709 D73G probably benign Het
Lpin1 G A 12: 16,573,699 S228L probably benign Het
Mtmr9 A G 14: 63,543,497 L48P probably damaging Het
Ncoa3 T A 2: 166,051,609 probably null Het
Ndc1 T A 4: 107,389,497 N372K probably benign Het
Ndufa2 A G 18: 36,744,175 probably benign Het
Nmt1 A T 11: 103,060,076 probably null Het
Olfr593 A T 7: 103,212,685 H264L probably damaging Het
Pcdhgb6 T C 18: 37,743,705 Y489H probably damaging Het
Rttn A T 18: 89,028,935 K907M probably damaging Het
Sos1 T C 17: 80,408,596 Y979C probably damaging Het
Spag6l C T 16: 16,767,013 A424T possibly damaging Het
Stt3b A T 9: 115,266,165 I266N probably damaging Het
Tet3 A G 6: 83,368,655 L1600P probably benign Het
Tiam1 T A 16: 89,794,739 I1358F probably damaging Het
Usp37 G T 1: 74,490,154 T122N probably benign Het
Vit T C 17: 78,579,401 S153P probably damaging Het
Other mutations in Soga3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Soga3 APN 10 29196473 nonsense probably null
IGL01450:Soga3 APN 10 29196323 missense probably damaging 1.00
IGL01462:Soga3 APN 10 29148258 missense probably damaging 1.00
IGL03062:Soga3 APN 10 29198949 missense probably damaging 1.00
R0534:Soga3 UTSW 10 29180956 splice site probably benign
R1355:Soga3 UTSW 10 29147322 missense probably benign 0.01
R1450:Soga3 UTSW 10 29147740 missense probably damaging 1.00
R1654:Soga3 UTSW 10 29146935 unclassified probably null
R1680:Soga3 UTSW 10 29196839 missense probably damaging 1.00
R2134:Soga3 UTSW 10 29196399 nonsense probably null
R2570:Soga3 UTSW 10 29146765 missense possibly damaging 0.88
R4395:Soga3 UTSW 10 29147355 missense probably benign
R4859:Soga3 UTSW 10 29150394 missense probably benign 0.00
R4883:Soga3 UTSW 10 29196541 missense probably damaging 1.00
R4884:Soga3 UTSW 10 29196541 missense probably damaging 1.00
R5288:Soga3 UTSW 10 29196770 missense probably benign 0.00
R5335:Soga3 UTSW 10 29147106 missense probably benign
R5384:Soga3 UTSW 10 29196770 missense probably benign 0.00
R5385:Soga3 UTSW 10 29196770 missense probably benign 0.00
R5457:Soga3 UTSW 10 29196724 missense probably benign 0.01
R5813:Soga3 UTSW 10 29150244 missense probably damaging 1.00
R5819:Soga3 UTSW 10 29197273 missense probably benign 0.00
R5950:Soga3 UTSW 10 29143648 unclassified probably benign
R6567:Soga3 UTSW 10 29147283 missense probably benign 0.00
R7312:Soga3 UTSW 10 29197244 missense probably damaging 1.00
R7313:Soga3 UTSW 10 29196879 nonsense probably null
R7445:Soga3 UTSW 10 29197003 missense possibly damaging 0.91
R7481:Soga3 UTSW 10 29196523 missense probably damaging 1.00
R7609:Soga3 UTSW 10 29148228 missense probably damaging 1.00
R7616:Soga3 UTSW 10 29146578 start gained probably benign
R7665:Soga3 UTSW 10 29196397 missense probably damaging 1.00
Posted On2013-04-17