Incidental Mutation 'IGL02083:Fmo6'
ID283441
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fmo6
Ensembl Gene ENSMUSG00000095576
Gene Nameflavin containing monooxygenase 6
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL02083
Quality Score
Status
Chromosome1
Chromosomal Location162916551-162937515 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 162920464 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 344 (K344*)
Ref Sequence ENSEMBL: ENSMUSP00000136378 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178465] [ENSMUST00000195576]
Predicted Effect probably null
Transcript: ENSMUST00000178465
AA Change: K344*
SMART Domains Protein: ENSMUSP00000136378
Gene: ENSMUSG00000095576
AA Change: K344*

DomainStartEndE-ValueType
Pfam:FMO-like 2 532 3.2e-273 PFAM
Pfam:Pyr_redox_2 3 226 2e-13 PFAM
Pfam:Pyr_redox_3 6 220 4.6e-17 PFAM
Pfam:K_oxygenase 79 223 1e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000195576
SMART Domains Protein: ENSMUSP00000144106
Gene: ENSMUSG00000095576

DomainStartEndE-ValueType
Pfam:FMO-like 2 118 5.1e-58 PFAM
Pfam:NAD_binding_8 7 84 2.2e-5 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap1 A C 11: 69,889,510 L36V possibly damaging Het
Atp13a3 T C 16: 30,347,706 T540A possibly damaging Het
Bend5 A C 4: 111,459,767 I376L probably benign Het
Ccdc138 T C 10: 58,544,914 probably benign Het
Cdh10 T A 15: 18,986,889 I402N possibly damaging Het
Cfap44 T C 16: 44,437,162 V1020A probably damaging Het
Chd2 A T 7: 73,481,068 S749T possibly damaging Het
Doxl2 G A 6: 48,976,260 G373D probably damaging Het
Enpp3 T A 10: 24,776,794 D755V probably damaging Het
Gabbr1 A G 17: 37,070,065 T767A possibly damaging Het
Gjd3 A G 11: 98,982,761 S86P probably damaging Het
Grin1 A G 2: 25,298,501 V432A possibly damaging Het
Igf2r A T 17: 12,693,192 C1849* probably null Het
Jcad G T 18: 4,680,266 probably benign Het
Mrgpra4 A T 7: 47,981,060 C264* probably null Het
Napepld T C 5: 21,676,067 Y110C probably damaging Het
Nat6 G T 9: 107,583,599 R231L probably benign Het
Ncapd3 A G 9: 27,051,821 E474G probably damaging Het
Pkhd1 T A 1: 20,201,227 D3034V probably damaging Het
Plxnc1 T C 10: 94,922,725 T370A possibly damaging Het
Ptger4 C T 15: 5,243,174 R13H probably benign Het
Scg2 T A 1: 79,436,224 T261S probably benign Het
Sfswap T C 5: 129,539,791 V433A probably benign Het
Sipa1l3 A G 7: 29,387,261 Y635H probably damaging Het
Sp5 C A 2: 70,476,414 P148T possibly damaging Het
Tlr5 A G 1: 182,973,884 N251S possibly damaging Het
Tmem87a A T 2: 120,397,380 N95K probably damaging Het
Unc45b C T 11: 82,922,919 T384M probably damaging Het
Unc5c T C 3: 141,714,647 L117P probably damaging Het
Vcan T C 13: 89,725,565 N57D probably damaging Het
Zcchc8 G T 5: 123,700,918 T519K probably damaging Het
Zfp729b G A 13: 67,595,230 T72I probably benign Het
Other mutations in Fmo6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01392:Fmo6 APN 1 162930011 nonsense probably null
adventure UTSW 1 162922810 missense probably benign
R0792:Fmo6 UTSW 1 162920563 missense probably damaging 0.98
R0940:Fmo6 UTSW 1 162926226 missense probably benign 0.07
R1173:Fmo6 UTSW 1 162926141 missense probably damaging 1.00
R1268:Fmo6 UTSW 1 162920517 missense probably damaging 1.00
R1538:Fmo6 UTSW 1 162926106 missense probably damaging 1.00
R1694:Fmo6 UTSW 1 162922672 missense probably benign
R1717:Fmo6 UTSW 1 162926252 nonsense probably null
R1837:Fmo6 UTSW 1 162922810 missense probably benign
R2125:Fmo6 UTSW 1 162929958 missense possibly damaging 0.82
R2434:Fmo6 UTSW 1 162916870 missense probably benign 0.00
R2894:Fmo6 UTSW 1 162922724 nonsense probably null
R4864:Fmo6 UTSW 1 162924395 missense probably benign 0.34
R6414:Fmo6 UTSW 1 162920445 missense probably damaging 0.97
R6576:Fmo6 UTSW 1 162922695 missense probably damaging 1.00
R6883:Fmo6 UTSW 1 162929892 missense probably damaging 1.00
R7013:Fmo6 UTSW 1 162918248 missense probably benign 0.00
R7014:Fmo6 UTSW 1 162926308 missense probably benign 0.13
R7657:Fmo6 UTSW 1 162922716 missense probably benign
X0025:Fmo6 UTSW 1 162920496 missense probably benign 0.29
X0025:Fmo6 UTSW 1 162922858 missense probably damaging 1.00
Z1176:Fmo6 UTSW 1 162926132 nonsense probably null
Posted On2015-04-16