Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02084:Mslnl'

283450

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mslnl

Ensembl Gene

ENSMUSG00000041062

Gene Name

mesothelin-like

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02084

Quality Score

Status

Chromosome

Chromosomal Location

25736040-25748330 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 25746151 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 497 (V497A)

Ref Sequence

ENSEMBL: ENSMUSP00000049020 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047098] [ENSMUST00000075884]

AlphaFold

Q8C160

Predicted Effect

probably benign
Transcript: ENSMUST00000047098
AA Change: V497A

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: V497A

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Mesothelin	29	589	2.8e-70	PFAM
low complexity region	633	653	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000075884

SMART Domains

Protein: ENSMUSP00000075279
Gene: ENSMUSG00000063011

Domain	Start	End	E-Value	Type
Pfam:Mesothelin	1	624	N/A	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000102319

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	G	11: 110,130,597	F1096L	probably benign	Het
Abcd2	T	A	15: 91,178,327		probably null	Het
Actr10	T	C	12: 70,954,649	I210T	probably damaging	Het
Apoa5	A	T	9: 46,270,652	D342V	probably damaging	Het
Bicra	G	A	7: 15,987,738	T618I	probably benign	Het
Birc6	C	A	17: 74,608,282	Q1642K	probably benign	Het
C130060K24Rik	T	C	6: 65,381,610	V106A	probably benign	Het
Cenpn	A	G	8: 116,940,895	Y331C	probably damaging	Het
Clcn7	T	A	17: 25,157,925	I624N	probably benign	Het
Eddm3b	A	T	14: 51,116,630	H25L	unknown	Het
Fam90a1a	A	G	8: 21,959,297	E19G	probably benign	Het
Fbxo18	T	C	2: 11,764,127	D285G	probably benign	Het
Fbxo41	A	T	6: 85,480,765		probably null	Het
Frem3	A	G	8: 80,612,443	D455G	possibly damaging	Het
Gart	T	C	16: 91,621,600	Q86R	probably benign	Het
Gm45234	T	C	6: 124,747,695		probably benign	Het
Gm5431	C	T	11: 48,889,085	D337N	probably benign	Het
Gm6882	T	A	7: 21,427,587	I119F	probably damaging	Het
Kcns3	C	T	12: 11,092,194	R168Q	probably damaging	Het
Klra17	T	A	6: 129,831,593	N226Y	probably damaging	Het
Macf1	T	C	4: 123,459,374	D1504G	probably damaging	Het
Macf1	T	C	4: 123,432,603	N2915D	probably benign	Het
Mgat4d	C	T	8: 83,368,981	S295L	possibly damaging	Het
Mtor	T	C	4: 148,470,680	S920P	probably damaging	Het
Mynn	C	A	3: 30,611,615	H465Q	probably damaging	Het
Myo16	A	G	8: 10,361,088	E182G	probably damaging	Het
Ncln	T	C	10: 81,488,596	I417V	probably benign	Het
Nlrp4f	A	T	13: 65,194,171	C553*	probably null	Het
Olfr1084	T	A	2: 86,639,636	Q24L	possibly damaging	Het
Olfr177	G	A	16: 58,873,036	T38I	probably damaging	Het
Pkhd1	T	C	1: 20,377,399	I2257V	probably damaging	Het
Ppp4r4	T	A	12: 103,600,398	S35T	possibly damaging	Het
Rnf213	T	C	11: 119,445,673	V3291A	probably benign	Het
Runx2	C	T	17: 44,724,829	A173T	probably damaging	Het
Ryr2	A	T	13: 11,792,762	Y833*	probably null	Het
Setbp1	G	A	18: 78,857,410	A1014V	probably damaging	Het
Slc25a38	A	G	9: 120,120,446		probably benign	Het
Stk4	A	G	2: 164,086,607	T120A	probably benign	Het
Taf3	A	T	2: 10,042,519	V106D	probably benign	Het
Uchl5	A	G	1: 143,802,174	I139V	possibly damaging	Het
Ung	A	G	5: 114,130,576	E25G	probably benign	Het
Wrn	A	G	8: 33,285,179	V619A	probably benign	Het

Other mutations in Mslnl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01621:Mslnl	APN	17	25743667	unclassified	probably benign
IGL01629:Mslnl	APN	17	25744775	missense	possibly damaging	0.95
IGL02408:Mslnl	APN	17	25747998	missense	possibly damaging	0.80
IGL02726:Mslnl	APN	17	25744103	critical splice donor site	probably null
IGL03387:Mslnl	APN	17	25744077	missense	probably benign	0.06
R0561:Mslnl	UTSW	17	25743203	nonsense	probably null
R0881:Mslnl	UTSW	17	25742965	missense	possibly damaging	0.82
R1295:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1296:Mslnl	UTSW	17	25743240	missense	probably damaging	1.00
R1582:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1629:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1630:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1631:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1632:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1794:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1850:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1866:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1876:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R1914:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2166:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2241:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2243:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2247:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2282:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2284:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2852:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2867:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2877:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2878:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2919:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R2920:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3026:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3405:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3406:Mslnl	UTSW	17	25746181	missense	probably damaging	1.00
R3411:Mslnl	UTSW	17	25744517	missense	probably benign	0.05
R3434:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3546:Mslnl	UTSW	17	25744969	missense	probably damaging	0.98
R3612:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3729:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3730:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3802:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3804:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3894:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R3895:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4454:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4455:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4456:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4457:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4561:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4562:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4564:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4600:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4601:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4610:Mslnl	UTSW	17	25742934	missense	probably damaging	0.97
R4704:Mslnl	UTSW	17	25738978	missense	possibly damaging	0.73
R5155:Mslnl	UTSW	17	25738968	nonsense	probably null
R5257:Mslnl	UTSW	17	25746165	missense	probably benign	0.00
R5456:Mslnl	UTSW	17	25743159	missense	probably damaging	0.98
R5645:Mslnl	UTSW	17	25737842	missense	possibly damaging	0.95
R6007:Mslnl	UTSW	17	25746775	missense	probably benign	0.00
R6083:Mslnl	UTSW	17	25737902	missense	possibly damaging	0.83
R6142:Mslnl	UTSW	17	25744557	missense	probably damaging	1.00
R6761:Mslnl	UTSW	17	25746073	missense	probably damaging	1.00
R7058:Mslnl	UTSW	17	25743212	missense	probably benign	0.03
R7156:Mslnl	UTSW	17	25743210	missense	probably benign	0.20
R7467:Mslnl	UTSW	17	25736921	start codon destroyed	probably benign	0.33
R7687:Mslnl	UTSW	17	25743183	missense	probably damaging	0.97
R7807:Mslnl	UTSW	17	25746777	missense	probably benign	0.03
R8682:Mslnl	UTSW	17	25746988	missense	probably benign
R8735:Mslnl	UTSW	17	25745088	missense	probably benign	0.09
R8742:Mslnl	UTSW	17	25745073	missense	probably damaging	1.00
R9208:Mslnl	UTSW	17	25742720	missense	possibly damaging	0.94
R9264:Mslnl	UTSW	17	25742532	intron	probably benign
RF007:Mslnl	UTSW	17	25743228	missense	possibly damaging	0.87

Posted On

2015-04-16