Incidental Mutation 'IGL02084:Nlrp4f'
ID 283453
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nlrp4f
Ensembl Gene ENSMUSG00000032999
Gene Name NLR family, pyrin domain containing 4F
Synonyms Nalp4f, C330026N02Rik, Nalp-kappa
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL02084
Quality Score
Status
Chromosome 13
Chromosomal Location 65324925-65353530 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 65341985 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 553 (C553*)
Ref Sequence ENSEMBL: ENSMUSP00000152418 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037372] [ENSMUST00000220448] [ENSMUST00000221659] [ENSMUST00000222514] [ENSMUST00000222559] [ENSMUST00000223418]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000037372
AA Change: C553*
SMART Domains Protein: ENSMUSP00000041908
Gene: ENSMUSG00000032999
AA Change: C553*

DomainStartEndE-ValueType
PYRIN 6 88 1.44e-26 SMART
Pfam:NACHT 147 316 3.4e-39 PFAM
LRR 632 659 1.18e1 SMART
LRR 686 713 4.22e1 SMART
LRR 715 742 5.66e1 SMART
LRR 743 769 4.03e0 SMART
LRR 771 798 1.17e0 SMART
LRR 799 826 1.43e-1 SMART
LRR 828 855 1.03e-2 SMART
LRR 856 883 5.59e-4 SMART
LRR 885 912 2.91e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000220448
Predicted Effect probably null
Transcript: ENSMUST00000221659
AA Change: C553*
Predicted Effect probably null
Transcript: ENSMUST00000222514
AA Change: C553*
Predicted Effect probably benign
Transcript: ENSMUST00000222559
Predicted Effect probably benign
Transcript: ENSMUST00000223418
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A G 11: 110,021,423 (GRCm39) F1096L probably benign Het
Abcd2 T A 15: 91,062,530 (GRCm39) probably null Het
Actr10 T C 12: 71,001,423 (GRCm39) I210T probably damaging Het
Apoa5 A T 9: 46,181,950 (GRCm39) D342V probably damaging Het
Bicra G A 7: 15,721,663 (GRCm39) T618I probably benign Het
Birc6 C A 17: 74,915,277 (GRCm39) Q1642K probably benign Het
Cenpn A G 8: 117,667,634 (GRCm39) Y331C probably damaging Het
Clcn7 T A 17: 25,376,899 (GRCm39) I624N probably benign Het
Eddm3b A T 14: 51,354,087 (GRCm39) H25L unknown Het
Fam90a1a A G 8: 22,449,313 (GRCm39) E19G probably benign Het
Fbh1 T C 2: 11,768,938 (GRCm39) D285G probably benign Het
Fbxo41 A T 6: 85,457,747 (GRCm39) probably null Het
Frem3 A G 8: 81,339,072 (GRCm39) D455G possibly damaging Het
Gart T C 16: 91,418,488 (GRCm39) Q86R probably benign Het
Gm45234 T C 6: 124,724,658 (GRCm39) probably benign Het
Gm5431 C T 11: 48,779,912 (GRCm39) D337N probably benign Het
Gm6882 T A 7: 21,161,512 (GRCm39) I119F probably damaging Het
Kcns3 C T 12: 11,142,195 (GRCm39) R168Q probably damaging Het
Klra17 T A 6: 129,808,556 (GRCm39) N226Y probably damaging Het
Macf1 T C 4: 123,326,396 (GRCm39) N2915D probably benign Het
Macf1 T C 4: 123,353,167 (GRCm39) D1504G probably damaging Het
Mgat4d C T 8: 84,095,610 (GRCm39) S295L possibly damaging Het
Mslnl T C 17: 25,965,125 (GRCm39) V497A probably benign Het
Mtor T C 4: 148,555,137 (GRCm39) S920P probably damaging Het
Mynn C A 3: 30,665,764 (GRCm39) H465Q probably damaging Het
Myo16 A G 8: 10,411,088 (GRCm39) E182G probably damaging Het
Ncln T C 10: 81,324,430 (GRCm39) I417V probably benign Het
Or5k14 G A 16: 58,693,399 (GRCm39) T38I probably damaging Het
Or8k37 T A 2: 86,469,980 (GRCm39) Q24L possibly damaging Het
Pkhd1 T C 1: 20,447,623 (GRCm39) I2257V probably damaging Het
Ppp4r4 T A 12: 103,566,657 (GRCm39) S35T possibly damaging Het
Qrfprl T C 6: 65,358,594 (GRCm39) V106A probably benign Het
Rnf213 T C 11: 119,336,499 (GRCm39) V3291A probably benign Het
Runx2 C T 17: 45,035,716 (GRCm39) A173T probably damaging Het
Ryr2 A T 13: 11,807,648 (GRCm39) Y833* probably null Het
Setbp1 G A 18: 78,900,625 (GRCm39) A1014V probably damaging Het
Slc25a38 A G 9: 119,949,512 (GRCm39) probably benign Het
Stk4 A G 2: 163,928,527 (GRCm39) T120A probably benign Het
Taf3 A T 2: 10,047,330 (GRCm39) V106D probably benign Het
Uchl5 A G 1: 143,677,912 (GRCm39) I139V possibly damaging Het
Ung A G 5: 114,268,637 (GRCm39) E25G probably benign Het
Wrn A G 8: 33,775,207 (GRCm39) V619A probably benign Het
Other mutations in Nlrp4f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01608:Nlrp4f APN 13 65,343,357 (GRCm39) nonsense probably null
IGL01676:Nlrp4f APN 13 65,342,933 (GRCm39) missense possibly damaging 0.95
IGL01701:Nlrp4f APN 13 65,347,223 (GRCm39) missense probably damaging 1.00
IGL01799:Nlrp4f APN 13 65,335,276 (GRCm39) missense probably benign 0.03
IGL02234:Nlrp4f APN 13 65,342,302 (GRCm39) missense probably damaging 1.00
IGL02481:Nlrp4f APN 13 65,342,548 (GRCm39) missense probably benign 0.04
IGL02483:Nlrp4f APN 13 65,342,548 (GRCm39) missense probably benign 0.04
IGL02625:Nlrp4f APN 13 65,347,085 (GRCm39) missense probably damaging 1.00
IGL02814:Nlrp4f APN 13 65,332,856 (GRCm39) missense probably damaging 0.98
IGL03077:Nlrp4f APN 13 65,342,412 (GRCm39) missense probably benign 0.10
IGL03111:Nlrp4f APN 13 65,330,816 (GRCm39) missense probably damaging 1.00
IGL03175:Nlrp4f APN 13 65,342,410 (GRCm39) missense probably damaging 1.00
IGL03324:Nlrp4f APN 13 65,343,042 (GRCm39) missense possibly damaging 0.91
R0398:Nlrp4f UTSW 13 65,342,732 (GRCm39) missense possibly damaging 0.79
R0477:Nlrp4f UTSW 13 65,338,720 (GRCm39) missense probably benign 0.01
R0707:Nlrp4f UTSW 13 65,342,317 (GRCm39) missense probably benign 0.42
R1052:Nlrp4f UTSW 13 65,332,897 (GRCm39) missense possibly damaging 0.73
R1302:Nlrp4f UTSW 13 65,342,371 (GRCm39) missense possibly damaging 0.77
R1460:Nlrp4f UTSW 13 65,338,082 (GRCm39) missense probably benign 0.23
R1970:Nlrp4f UTSW 13 65,341,905 (GRCm39) missense probably damaging 1.00
R2111:Nlrp4f UTSW 13 65,347,167 (GRCm39) missense probably benign 0.11
R2272:Nlrp4f UTSW 13 65,342,222 (GRCm39) missense probably benign 0.01
R2370:Nlrp4f UTSW 13 65,338,660 (GRCm39) missense probably damaging 0.99
R2680:Nlrp4f UTSW 13 65,342,157 (GRCm39) nonsense probably null
R3120:Nlrp4f UTSW 13 65,342,530 (GRCm39) missense probably benign 0.13
R3737:Nlrp4f UTSW 13 65,341,821 (GRCm39) missense probably benign 0.01
R4035:Nlrp4f UTSW 13 65,341,821 (GRCm39) missense probably benign 0.01
R4107:Nlrp4f UTSW 13 65,330,879 (GRCm39) missense probably benign 0.01
R4422:Nlrp4f UTSW 13 65,332,776 (GRCm39) critical splice donor site probably null
R4718:Nlrp4f UTSW 13 65,342,803 (GRCm39) missense probably benign 0.01
R5652:Nlrp4f UTSW 13 65,330,803 (GRCm39) missense probably benign 0.00
R5656:Nlrp4f UTSW 13 65,338,685 (GRCm39) nonsense probably null
R5912:Nlrp4f UTSW 13 65,342,722 (GRCm39) missense probably damaging 0.99
R5915:Nlrp4f UTSW 13 65,335,369 (GRCm39) missense probably damaging 1.00
R5955:Nlrp4f UTSW 13 65,342,895 (GRCm39) missense probably benign 0.15
R6683:Nlrp4f UTSW 13 65,347,009 (GRCm39) missense probably benign 0.01
R6742:Nlrp4f UTSW 13 65,335,254 (GRCm39) critical splice donor site probably null
R6750:Nlrp4f UTSW 13 65,329,468 (GRCm39) nonsense probably null
R6751:Nlrp4f UTSW 13 65,342,243 (GRCm39) missense probably damaging 0.99
R7110:Nlrp4f UTSW 13 65,347,160 (GRCm39) missense probably damaging 0.96
R7143:Nlrp4f UTSW 13 65,347,166 (GRCm39) missense possibly damaging 0.90
R7143:Nlrp4f UTSW 13 65,343,120 (GRCm39) missense probably damaging 1.00
R7187:Nlrp4f UTSW 13 65,343,201 (GRCm39) missense possibly damaging 0.47
R7230:Nlrp4f UTSW 13 65,342,715 (GRCm39) missense probably benign 0.16
R7283:Nlrp4f UTSW 13 65,343,352 (GRCm39) nonsense probably null
R7501:Nlrp4f UTSW 13 65,342,143 (GRCm39) missense probably damaging 0.99
R7863:Nlrp4f UTSW 13 65,342,059 (GRCm39) missense possibly damaging 0.63
R7889:Nlrp4f UTSW 13 65,342,832 (GRCm39) missense probably damaging 1.00
R8472:Nlrp4f UTSW 13 65,342,145 (GRCm39) missense possibly damaging 0.87
R8553:Nlrp4f UTSW 13 65,343,252 (GRCm39) missense possibly damaging 0.66
R8972:Nlrp4f UTSW 13 65,330,749 (GRCm39) missense probably benign 0.13
R9133:Nlrp4f UTSW 13 65,332,883 (GRCm39) nonsense probably null
R9224:Nlrp4f UTSW 13 65,332,829 (GRCm39) nonsense probably null
R9460:Nlrp4f UTSW 13 65,342,006 (GRCm39) missense possibly damaging 0.79
R9562:Nlrp4f UTSW 13 65,347,053 (GRCm39) missense probably damaging 0.99
Z1088:Nlrp4f UTSW 13 65,342,116 (GRCm39) missense probably benign 0.00
Z1177:Nlrp4f UTSW 13 65,342,475 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16